Описание: A guide to compound screening in pharmaceutical research and chemical biology, including chemoinformatic tools useful for data evaluation. It discusses such factors as chemical genetics, binding, cell based and biochemical assays, the use of compound libraries and data mining. It is useful for academics and professionals in biotech industries.
Автор: Janzen Название: High Throughput Screening ISBN: 1493936719 ISBN-13(EAN): 9781493936717 Издательство: Springer Рейтинг: Цена: 17819 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This third edition volumeexpands on the previous editions both by presenting more detailed protocols forthe techniques described in the first and second editions of High ThroughputScreening: Methods and Protocolsand by covering important new procedures. The first chapter ofthis book provides an overview of important assay development techniques, whilethe rest of the chapters detail how to develop and execute screens at whateverthroughput the user needs. Some chapter examples are: structure-based virtualscreening, high throughput screening using mass spectrometry, identification of state-dependentblockers for voltage gated calcium channels, bioluminescence resonanceenergy transfer platform to monitor protein-protein interactions in live cells,high throughput flow cytometry, and application of imaging-based assays in microplate formats for highcontent screening. Written in the highly successful Methods in MolecularBiology series format, chapters include introductions to their respectivetopics, lists of the necessary materials and reagents, step-by-step, readilyreproducible laboratory protocols, and tips on troubleshooting and avoidingknown pitfalls.Cutting edge and thorough, High Throughput Screening: Methods and Protocols,Third Edition, is a valuable resource for anyone who is interested in HTSresearch.
Описание: High Throughput Formulation Development of Biopharmaceuticals: Practical Guide to Methods and Applications provides the latest developments and information on the science of stable and safe drug product formulations, presenting a comprehensive review and detailed description of modern methodologies in the field of formulation development, a process starting with candidate and pre-formulation screening in its early development phase and then progressing to the refinement of robust formulations during commercialization in the later phases of development. The title covers topics such as experiment design, automation of sample preparation and measurements, high-throughput analytics, stress-inducing methods, statistical analysis of large amounts of formulation study data, emerging technologies, and the presentation of several case studies, along with a concluding summary.
Описание: Parallel synthesis has become a mainstay in modern drug discovery. For the first time, the numerous topics relating to lead optimization using the parallel
synthesis method are described in this one volume. "High-Throughput Lead Optimization in Drug Discovery" describes both the application of parallel synthesis towards lead optimization
as well as the design and synthesis of targeted libraries.
Featuring real world examples and contributions from well-known scientists, this book reflects the shift toward
conducting parallel lead optimization in-house while outsourcing most of the screening libraries synthesis.
Описание: Covers recent advances in molecular biochemistry as they relate to the improvement of food quality. The volume includes a broad range of topics including flavor perception and compounds affecting flavour, quality analysis and reseach applications, food microbiology and safey issues.
Описание: Plant Hazard Analysis and Safety Instrumentation Systems is the first book to combine coverage of these two integral aspects of running a chemical processing plant. It helps engineers from various disciplines learn how various analysis techniques, international standards, and instrumentation and controls provide layers of protection for basic process control systems, and how, as a result, overall system reliability, availability, dependability, and maintainability can be increased. . This step-by-step guide takes readers through the development of safety instrumented systems, also including discussions on cost impact, basics of statistics, and reliability. Swapan Basu brings more than 35 years of industrial experience to this book, using practical examples to demonstrate concepts. . Basu links between the SIS requirements and process hazard analysis in order to complete SIS lifecycle implementation and covers safety analysis and realization in control systems, with up-to-date descriptions of modern concepts, such as SIL, SIS, and Fault Tolerance to name a few. In addition, the book addresses security issues that are particularly important for the programmable systems in modern plants, and discusses, at length, hazardous atmospheres and their impact on electrical enclosures and the use of IS circuits.
State-of-the-Art Methods for Drug Safety Assessment
Responding to the increased scrutiny of drug safety in recent years, Quantitative Evaluation of Safety in Drug Development: Design, Analysis and Reporting explains design, monitoring, analysis, and reporting issues for both clinical trials and observational studies in biopharmaceutical product development. It presents the latest statistical methods for drug safety assessment.
The book's three sections focus on study design, safety monitoring, and data evaluation/analysis. The book addresses key challenges across regulatory agencies, industry, and academia. It discusses quantitative approaches to safety evaluation and risk management in drug development, covering Bayesian methods, effective safety graphics, and risk-benefit evaluation.
Written by a team of experienced leaders, this book brings the most advanced knowledge and statistical methods of drug safety to the statistical, clinical, and safety community. It shares best practices and stimulates further research and methodology development in the drug safety area.
Описание: This book summarises the latest research on sensor technologies for online and high-throughput screening of food.
Название: High Throughput Screening In Drug D ISBN: 1498708021 ISBN-13(EAN): 9781498708029 Издательство: Taylor&Francis Рейтинг: Цена: 22688 р. Наличие на складе: Поставка под заказ.
Описание: Drug discovery is a highly complex and multidisciplinary process. High throughput screening (HTS) uses the technologies of automation to collect a large amount of experimental data in a relatively short time. This book presents a comprehensive view of the HTS process for drug discovery, with its benefits and pitfalls, advantages, and problems. It provides an overview of different platforms and examples of successful applications of HTS in drug discovery using different technologies applied to each specific project.
Sample preparation is an everyday part ofan Analytical Chemist's workflow and this booksupports researches in optimizing their work, byoutlining the latest preparation techniquesfrom around the globe. Answers are provided to such questions as - How do I automate a procedure? Who are the vendors that offer options? How do I work to reduce matrix interferences? Could I do this procedure on-line instead of in a batch manually? Who are the vendors offering automation options? Who are the 96-well SPE plate manufacturers? What sorbent materials are available in the market? How do I use a cation exchange resin? What has been published on micro-sampling techniques? What is a molecularly imprinted polymer? Can liquid-liquid extraction be used in a plate format? How do I seal microplates after elution? Can I elute analytes in tiny microliter volumes? How do I evaporate eluates in a microplate? How can I use my LEAP auto-sampler to perform sample prep? Which microplate can work with 50 microliter sample volumes? Addressing the workflow pain points of productivity and extraction process efficiency, this bookoutlines exactly how to make methods more productive and how to develop and optimize methods to be as efficient as possible. No other book provides this step-by-step approach coupled with a thorough explanation of the technology, making it the go-to reference book in the field for analytical scientists in industry. "
New to This Edition" The new edition will feature 40% new content and 60% revised content, accurately and thoroughly capturing the latest developments in research since the previous edition published in 2003. Detailed coverage of the newer techniques that have emerged since the first edition published are featured, including:
Micro sampling techniques
Molecularly imprinted polymers (MIP)
Proteomic and genomic sample preparation
Working with difficult matrices
Novel polymers and other substrate materials
Chip-based sample preparation
Autosampler-based sample preparation hardware Sample preparation for biosimilars and biotherapeutic proteins Offers broad coverage of all sample preparation methods and techniques-including the latest industry developments-within bioanalysisProvides detailed How-To approaches for each technique, making its applications immediately implementableAuthored by an industry analytical chemist who has more than 30 years of experience in all facets of sample preparation, drug analysis, and moreFeatures a thorough and inclusive bibliography of related publications in the field"
Описание: Since the independent invention of DNA sequencing by Sanger and by Gilbert 30 years ago, it has grown from a small scale technique capable of reading several kilobase-pair of sequence per day into today's multibillion dollar industry. This growth has spurred the development of new sequencing technologies that do not involve either electrophoresis or Sanger sequencing chemistries. Sequencing by Synthesis (SBS) involves multiple parallel micro-sequencing addition events occurring on a surface, where data from each round is detected by imaging. New High Throughput Technologies for DNA Sequencing and Genomics is the second volume in the Perspectives in Bioanalysis series, which looks at the electroanalytical chemistry of nucleic acids and proteins, development of electrochemical sensors and their application in biomedicine and in the new fields of genomics and proteomics. The authors have expertly formatted the information for a wide variety of readers, including new developments that will inspire students and young scientists to create new tools for science and medicine in the 21st century.Reviews of complementary developments in Sanger and SBS sequencing chemistries, capillary electrophoresis and microdevice integration, MS sequencing and applications set the framework for the book.
Описание: The work reviews the areas of process intensification and micro-instrumentation and shows how these intertwine to enable a novel strategy for process development and improved control resulting from rapid real time analysis. The book is introductory to some of the approaches of how to use micro-instrumentation, but yet advanced relative to the combination of technologies that are described and the applications presented.
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