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High Throughput Screening, Janzen



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Цена: 17819р.
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Наличие: Поставка под заказ.  Есть в наличии на складе поставщика.
Склад Англия: 597 шт.  Склад Америка: 64 шт.  
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Автор: Janzen
Название:  High Throughput Screening
ISBN: 9781493936717
Издательство: Springer
Классификация:
ISBN-10: 1493936719
Обложка/Формат: Hardback
Страницы: 308
Вес: 0.797 кг.
Дата издания: 2016
Серия: Methods in Molecular Biology
Язык: English
Издание: 3 revised edition
Иллюстрации: 78 tables, color; 71 illustrations, color; 30 illustrations, black and white; xi, 308 p. 101 illus., 71 illus. in color.
Размер: 254 x 178 x 19
Читательская аудитория: General (us: trade)
Основная тема: Chemistry
Подзаголовок: Methods and Protocols
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Германии
Дополнительное описание: Design and Implementation of High Throughput Screening Assays.- Characterization of InhibitorBinding Through Multiple Inhibitor Analysis: A Novel Local Fitting Method.- High Throughput Screening UsingMass Spectrometry within Drug Discovery.- Structure-Bas




High-Throughput Screening in Drug Discovery

Автор: H?ser
Название: High-Throughput Screening in Drug Discovery
ISBN: 3527312838 ISBN-13(EAN): 9783527312832
Издательство: Wiley
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Цена: 34485 р.
Наличие на складе: Поставка под заказ.

Описание: A guide to compound screening in pharmaceutical research and chemical biology, including chemoinformatic tools useful for data evaluation. It discusses such factors as chemical genetics, binding, cell based and biochemical assays, the use of compound libraries and data mining. It is useful for academics and professionals in biotech industries.

Название: High Throughput Screening In Drug D
ISBN: 1498708021 ISBN-13(EAN): 9781498708029
Издательство: Taylor&Francis
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Цена: 22688 р.
Наличие на складе: Поставка под заказ.

Описание: Drug discovery is a highly complex and multidisciplinary process. High throughput screening (HTS) uses the technologies of automation to collect a large amount of experimental data in a relatively short time. This book presents a comprehensive view of the HTS process for drug discovery, with its benefits and pitfalls, advantages, and problems. It provides an overview of different platforms and examples of successful applications of HTS in drug discovery using different technologies applied to each specific project.

High Throughput Screening for Food Safety Assessment: Biosensor Technologies, Hyperspectral Imaging and Practical Applications

Автор: Bhunia Arun K., Kim Moon S., Taitt Chris R.
Название: High Throughput Screening for Food Safety Assessment: Biosensor Technologies, Hyperspectral Imaging and Practical Applications
ISBN: 0857098012 ISBN-13(EAN): 9780857098016
Издательство: Elsevier Science
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Цена: 35640 р.
Наличие на складе: Поставка под заказ.

Описание: This book summarises the latest research on sensor technologies for online and high-throughput screening of food.

Virtual Screening / An Alternative or Complement to High Throughput Screening

Автор: Klebe Gerhard
Название: Virtual Screening / An Alternative or Complement to High Throughput Screening
ISBN: 0792366336 ISBN-13(EAN): 9780792366331
Издательство: Springer
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Цена: 34007 р.
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Описание: Preface. Combination of molecular similarity measures using data fusion; C.M.R. Ginn, et al. Optimization of the drug-likeness of chemical libraries; J. Sadowski. Generating consistent sets of thermodynamic and structural data form analysis of protein-ligand interactions; T. Davies, et al. Multiple molecular superpositioning as an effective tool for virtual database screening; C. Lemmen, et al. A recursive algorithm for efficient combinatorial library docking; M. Rarey, T. Lengauer. Modifications of the scoring function in FlexX for virtual screening applications; M. Stahl. A knowledge-based scoring function for protein-ligand interactions: Probing the reference state; I. Muegge. Predicting binding modes, binding affinities and `hot spots' for protein-ligand complexes using a knowledge-based scoring function; H. Gohlke, et al. Hydrophobicity maps and docking of molecular fragments with solvation; N. Majeux, et al. Virtual screening with solvation and ligand-induced complementarity; V. Schnecke, L.A. Kuhn. Similarity versus docking in 3 D virtual screening; J. Mestres, R.M.A. Knegtel. Discovering high-affinity ligands from the computationally predicted structures and affinities of small molecules bound to a target: A virtual screening approach; T.J. Marrone, et al. In vitro and in silico affinity fingerprints: Finding similarities beyond structural classes; H. Briem, U.F. Lessel. Computer-assisted synthesis and reaction planning in combinatorial chemistry; J. Gasteiger, et al. Evaluation of reactant-based and product-based approaches to the design of combinatorial libraries; V.J. Gillet, O. Nicolotti.

High-Throughput Screening Assays in Toxicology

Автор: Zhu
Название: High-Throughput Screening Assays in Toxicology
ISBN: 1493963449 ISBN-13(EAN): 9781493963447
Издательство: Springer
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Цена: 19304 р.
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Описание: This book focuses on recently developed High Throughput Screening (HTS) assay protocols, many involved in the ToxCast and/or Tox21 initiatives, and the relevant HTS data analysis techniques. Divided into three sections, in vitro assays, in vivo assays, and computational techniques to analyze HTS data are all examined. Written for the highly successful Methods in Molecular Biology series, most chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, High Throughput Screening Assays in Toxicology serves as a valuable reference resource for translating new HTS techniques into standardized chemical toxicity assessment tools in order to advance modern toxicology research to a new era where HTS techniques can partially replace the prevailing animal models.
High Throughput Bioanalytical Sample Preparation, 2e

Автор: David A. Wells
Название: High Throughput Bioanalytical Sample Preparation, 2e
ISBN: 0444637583 ISBN-13(EAN): 9780444637581
Издательство: Elsevier Science
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Цена: 41580 р.
Наличие на складе: Поставка под заказ.

Описание:

Sample preparation is an everyday part ofan Analytical Chemist's workflow and this booksupports researches in optimizing their work, byoutlining the latest preparation techniquesfrom around the globe. Answers are provided to such questions as - How do I automate a procedure? Who are the vendors that offer options? How do I work to reduce matrix interferences? Could I do this procedure on-line instead of in a batch manually? Who are the vendors offering automation options? Who are the 96-well SPE plate manufacturers? What sorbent materials are available in the market? How do I use a cation exchange resin? What has been published on micro-sampling techniques? What is a molecularly imprinted polymer? Can liquid-liquid extraction be used in a plate format? How do I seal microplates after elution? Can I elute analytes in tiny microliter volumes? How do I evaporate eluates in a microplate? How can I use my LEAP auto-sampler to perform sample prep? Which microplate can work with 50 microliter sample volumes? Addressing the workflow pain points of productivity and extraction process efficiency, this bookoutlines exactly how to make methods more productive and how to develop and optimize methods to be as efficient as possible. No other book provides this step-by-step approach coupled with a thorough explanation of the technology, making it the go-to reference book in the field for analytical scientists in industry. "

New to This Edition" The new edition will feature 40% new content and 60% revised content, accurately and thoroughly capturing the latest developments in research since the previous edition published in 2003. Detailed coverage of the newer techniques that have emerged since the first edition published are featured, including:

Micro sampling techniques

Molecularly imprinted polymers (MIP)

Proteomic and genomic sample preparation

Working with difficult matrices

Novel polymers and other substrate materials

Chip-based sample preparation

Autosampler-based sample preparation hardware Sample preparation for biosimilars and biotherapeutic proteins
Offers broad coverage of all sample preparation methods and techniques-including the latest industry developments-within bioanalysisProvides detailed How-To approaches for each technique, making its applications immediately implementableAuthored by an industry analytical chemist who has more than 30 years of experience in all facets of sample preparation, drug analysis, and moreFeatures a thorough and inclusive bibliography of related publications in the field"

High Throughput Formulation Development of Biopharmaceuticals

Автор: Vladimir I. Razinkov
Название: High Throughput Formulation Development of Biopharmaceuticals
ISBN: 1907568638 ISBN-13(EAN): 9781907568633
Издательство: Elsevier Science
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Цена: 21978 р.
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Описание: High Throughput Formulation Development of Biopharmaceuticals: Practical Guide to Methods and Applications provides the latest developments and information on the science of stable and safe drug product formulations, presenting a comprehensive review and detailed description of modern methodologies in the field of formulation development, a process starting with candidate and pre-formulation screening in its early development phase and then progressing to the refinement of robust formulations during commercialization in the later phases of development. The title covers topics such as experiment design, automation of sample preparation and measurements, high-throughput analytics, stress-inducing methods, statistical analysis of large amounts of formulation study data, emerging technologies, and the presentation of several case studies, along with a concluding summary.

High Throughput Analysis for Food Safety

Автор: Perry G. Wang,Mark F. Vitha,Jack F. Kay
Название: High Throughput Analysis for Food Safety
ISBN: 1118396308 ISBN-13(EAN): 9781118396308
Издательство: Wiley
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Цена: 17778 р.
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Описание: This book focuses on high–throughput analyses for food safety. Because of the contributors domestic and international expertise from industry and government the book appeals to a wider audience. It includes the latest development in rapid screening, with a particular emphasis on the growing use and applicability of a variety of stand–alone mass spectrometry methods as well as using mass spectrometry in hyphenated techniques such as gas chromatograph mass spectrometry (GC–MS) and liquid chromatography mass spectrometry (LC–MS). Readers will be educated to the field of food safety and rapid testing in the most commonly used techniques. Divided into three parts (Basics of High Throughput Analyses, Mass Spectrometry in High Throughput Analyses, and International Food Safety Testing) this book covers many important aspects of high–throughput analyses for food safety.

High-Throughput Lead Optimization in Drug Discovery

Автор: Tushar Kshirsagar
Название: High-Throughput Lead Optimization in Drug Discovery
ISBN: 0849372682 ISBN-13(EAN): 9780849372681
Издательство: Taylor&Francis
Рейтинг:
Цена: 29040 р.
Наличие на складе: Поставка под заказ.

Описание: Parallel synthesis has become a mainstay in modern drug discovery. For the first time, the numerous topics relating to lead optimization using the parallel synthesis method are described in this one volume. "High-Throughput Lead Optimization in Drug Discovery" describes both the application of parallel synthesis towards lead optimization as well as the design and synthesis of targeted libraries.

Featuring real world examples and contributions from well-known scientists, this book reflects the shift toward conducting parallel lead optimization in-house while outsourcing most of the screening libraries synthesis.

Experimental Design for Combinatorial and High Throughput Materials Development

Автор: James N. Cawse
Название: Experimental Design for Combinatorial and High Throughput Materials Development
ISBN: 0471203432 ISBN-13(EAN): 9780471203438
Издательство: Wiley
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Цена: 25410 р.
Наличие на складе: Поставка под заказ.

Описание: An invaluable reference to increasingly popular experimental methods In the past decade, combinatorial and high throughput experimental methods have revolutionized the pharmaceutical industry, allowing researchers to conduct more experiments in a week than was previously possible in a year. Now high throughput experimentation is rapidly spreading from its origins in the pharmaceutil world to larger industrial research establishments such as GE and DuPont, and even to smaller companies and universities. Consequently, researchers need to know the kinds of problems, desired outcomes, and appropriate patterns for these new strategies. Editor James Cawse's far-reaching study identifies and applies, with specific examples, these important new principles and techniques. Experimental Design for Combinatorial and High Throughput Materials Development progresses from methods that are now standard, such as gradient arrays, to mathematical developments that are breaking new ground. The former will be particularly useful to researchers entering the field, while the latter should inspire and challenge advanced practitioners. The book's contents are contributed by leading researchers in their respective fields. Chapters include: High Throughput Synthetic Approaches for the Investigation of Inorganic Phase Space Combinatorial Mapping of Polymer Blends Phase Behavior Split-Plot Designs Artificial Neural Networks in Catalyst Development The Monte Carlo Approach to Library Design and Redesign The text also contains over 200 useful charts and drawings. Industrial chemists, chemical engineers, materials scientists, and physicists working in combinatorial and high throughput chemistry will find James Cawse's study to be an invaluable resource.

Micro Instrumentation: for High Throughput Experimentation and Process Intensification

Автор: Koch
Название: Micro Instrumentation: for High Throughput Experimentation and Process Intensification
ISBN: 3527314253 ISBN-13(EAN): 9783527314256
Издательство: Wiley
Рейтинг:
Цена: 22688 р.
Наличие на складе: Поставка под заказ.

Описание: The work reviews the areas of process intensification and micro-instrumentation and shows how these intertwine to enable a novel strategy for process development and improved control resulting from rapid real time analysis. The book is introductory to some of the approaches of how to use micro-instrumentation, but yet advanced relative to the combination of technologies that are described and the applications presented.

High Content Screening - Science, Techniques, and Applications +CD

Автор: Haney
Название: High Content Screening - Science, Techniques, and Applications +CD
ISBN: 047003999X ISBN-13(EAN): 9780470039991
Издательство: Wiley
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Цена: 25229 р.
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Описание: A reference on High Content Screening (HCS) in biological and pharmaceutical research. It covers: the basics of HCS - examples of HCS used in biological applications and early drug discovery, emphasizing oncology and neuroscience; the use of HCS across the drug development pipeline; and data management, data analysis, and systems biology.


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