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High-Throughput Screening Assays in Toxicology, Zhu



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Цена: 19304р.
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Автор: Zhu
Название:  High-Throughput Screening Assays in Toxicology
ISBN: 9781493963447
Издательство: Springer
Классификация:
ISBN-10: 1493963449
Обложка/Формат: Hardback
Страницы: 175
Вес: 0.558 кг.
Дата издания: 2016
Серия: Methods in Molecular Biology
Язык: English
Издание: 1st ed. 2016
Иллюстрации: 27 tables, color; 32 illustrations, color; 18 illustrations, black and white; xii, 175 p. 50 illus., 32 illus. in color.
Размер: 254 x 178 x 13
Читательская аудитория: General (us: trade)
Основная тема: Biomedicine
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Германии
Дополнительное описание: Monitoring Ligand-Activated Protein-Protein Interactions Using Bioluminescent Resonance Energy Transfer (BRET) Assay.- Mitochondrial Membrane Potential Assay.- Using ?-Lactamase and NanoLuc Luciferase Reporter Gene Assays to Identify Inhibitors of the HIF




High Throughput Screening

Автор: Janzen
Название: High Throughput Screening
ISBN: 1493936719 ISBN-13(EAN): 9781493936717
Издательство: Springer
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Цена: 17819 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This third edition volumeexpands on the previous editions both by presenting more detailed protocols forthe techniques described in the first and second editions of High ThroughputScreening: Methods and Protocolsand by covering important new procedures. The first chapter ofthis book provides an overview of important assay development techniques, whilethe rest of the chapters detail how to develop and execute screens at whateverthroughput the user needs. Some chapter examples are: structure-based virtualscreening, high throughput screening using mass spectrometry, identification of state-dependentblockers for voltage gated calcium channels, bioluminescence resonanceenergy transfer platform to monitor protein-protein interactions in live cells,high throughput flow cytometry, and application of imaging-based assays in microplate formats for highcontent screening. Written in the highly successful Methods in MolecularBiology series format, chapters include introductions to their respectivetopics, lists of the necessary materials and reagents, step-by-step, readilyreproducible laboratory protocols, and tips on troubleshooting and avoidingknown pitfalls.Cutting edge and thorough, High Throughput Screening: Methods and Protocols,Third Edition, is a valuable resource for anyone who is interested in HTSresearch.

Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays

Автор: Vogel
Название: Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays
ISBN: 3642252397 ISBN-13(EAN): 9783642252396
Издательство: Springer
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Цена: 103949 р.
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Описание: Safety aspects have become an outstanding issue in the process of drug discovery and development. Until 15 years ago safety aspects were addressed by pharmacological testing of the selected compound in high doses in tests directed at indications other than the intended indication of the new compound. These tests were followed by pharmacokinetic studies, which were mainly aimed at confirming of a suitable half-life time and at oral activity. Safety aspects relied mostly on toxicity studies, which however gave information on changes of organ structure rather than on organ function. Toxicological and pharmacokinetic studies were adapted to the progress of studies in clinical pharmacology and clinical trails. But the success rate in the pharmaceutical industry and the introduction of new chemical entities to the market per year dropped dramatically, whereas the development time for a new compound increased, sometimes exceeding the patent protection. A change of strategy was therefore adopted, involving the following changes: -          Parallel instead of sequential involvement of the various disciplines (multidimensional compound optimization).-          The term Safety Pharmacology was coined. The International Conference on Harmonization (ICH) founded a Safety Pharmacology Working Group. Easily accessible and the most informative tests now have to be selected.-          Exposure of a drug to the body by pharmacokinetic studies on absorption, distribution, metabolism and excretion has to be investigated at an early stage of development and can contribute to the selection of a compound for development. Toxicology experienced major achievements by the introduction of new methods, e.g., in silico methods, toxicogenomics and toxicoproteomics.The book is a landmark in the continuously changing world of drugs. As such it is important reading for many groups: not only for all students of pharmacology and toxicology but also for physicians, especially those involved in clinical trials of drugs, and for pharmacists who have to know the safety requirements of drugs.The book is absolutely essential for scientists and managers in the pharmaceutical industry who are involved in drug finding, drug development and decision making in the development process.In particular, the book will be of use for government institutions and committees working on official guidelines for drug evaluation worldwide.

Virtual Screening / An Alternative or Complement to High Throughput Screening

Автор: Klebe Gerhard
Название: Virtual Screening / An Alternative or Complement to High Throughput Screening
ISBN: 0792366336 ISBN-13(EAN): 9780792366331
Издательство: Springer
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Цена: 34007 р.
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Описание: Preface. Combination of molecular similarity measures using data fusion; C.M.R. Ginn, et al. Optimization of the drug-likeness of chemical libraries; J. Sadowski. Generating consistent sets of thermodynamic and structural data form analysis of protein-ligand interactions; T. Davies, et al. Multiple molecular superpositioning as an effective tool for virtual database screening; C. Lemmen, et al. A recursive algorithm for efficient combinatorial library docking; M. Rarey, T. Lengauer. Modifications of the scoring function in FlexX for virtual screening applications; M. Stahl. A knowledge-based scoring function for protein-ligand interactions: Probing the reference state; I. Muegge. Predicting binding modes, binding affinities and `hot spots' for protein-ligand complexes using a knowledge-based scoring function; H. Gohlke, et al. Hydrophobicity maps and docking of molecular fragments with solvation; N. Majeux, et al. Virtual screening with solvation and ligand-induced complementarity; V. Schnecke, L.A. Kuhn. Similarity versus docking in 3 D virtual screening; J. Mestres, R.M.A. Knegtel. Discovering high-affinity ligands from the computationally predicted structures and affinities of small molecules bound to a target: A virtual screening approach; T.J. Marrone, et al. In vitro and in silico affinity fingerprints: Finding similarities beyond structural classes; H. Briem, U.F. Lessel. Computer-assisted synthesis and reaction planning in combinatorial chemistry; J. Gasteiger, et al. Evaluation of reactant-based and product-based approaches to the design of combinatorial libraries; V.J. Gillet, O. Nicolotti.

High-Throughput Screening Methods in Toxicity Testing

Автор: Steinberg
Название: High-Throughput Screening Methods in Toxicity Testing
ISBN: 1118065638 ISBN-13(EAN): 9781118065631
Издательство: Wiley
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Цена: 23595 р.
Наличие на складе: Поставка под заказ.

Описание: High-throughput assays are part of a paradigm shift, to more cost-effective and reliable methods, in the testing of chemical and drug safety. This book covers methods, data generation, data analysis, and applications in risk assessment for major toxic

Название: High Throughput Screening In Drug D
ISBN: 1498708021 ISBN-13(EAN): 9781498708029
Издательство: Taylor&Francis
Рейтинг:
Цена: 22688 р.
Наличие на складе: Поставка под заказ.

Описание: Drug discovery is a highly complex and multidisciplinary process. High throughput screening (HTS) uses the technologies of automation to collect a large amount of experimental data in a relatively short time. This book presents a comprehensive view of the HTS process for drug discovery, with its benefits and pitfalls, advantages, and problems. It provides an overview of different platforms and examples of successful applications of HTS in drug discovery using different technologies applied to each specific project.

High Throughput Bioanalytical Sample Preparation, 2e

Автор: David A. Wells
Название: High Throughput Bioanalytical Sample Preparation, 2e
ISBN: 0444637583 ISBN-13(EAN): 9780444637581
Издательство: Elsevier Science
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Цена: 41580 р.
Наличие на складе: Поставка под заказ.

Описание:

Sample preparation is an everyday part ofan Analytical Chemist's workflow and this booksupports researches in optimizing their work, byoutlining the latest preparation techniquesfrom around the globe. Answers are provided to such questions as - How do I automate a procedure? Who are the vendors that offer options? How do I work to reduce matrix interferences? Could I do this procedure on-line instead of in a batch manually? Who are the vendors offering automation options? Who are the 96-well SPE plate manufacturers? What sorbent materials are available in the market? How do I use a cation exchange resin? What has been published on micro-sampling techniques? What is a molecularly imprinted polymer? Can liquid-liquid extraction be used in a plate format? How do I seal microplates after elution? Can I elute analytes in tiny microliter volumes? How do I evaporate eluates in a microplate? How can I use my LEAP auto-sampler to perform sample prep? Which microplate can work with 50 microliter sample volumes? Addressing the workflow pain points of productivity and extraction process efficiency, this bookoutlines exactly how to make methods more productive and how to develop and optimize methods to be as efficient as possible. No other book provides this step-by-step approach coupled with a thorough explanation of the technology, making it the go-to reference book in the field for analytical scientists in industry. "

New to This Edition" The new edition will feature 40% new content and 60% revised content, accurately and thoroughly capturing the latest developments in research since the previous edition published in 2003. Detailed coverage of the newer techniques that have emerged since the first edition published are featured, including:

Micro sampling techniques

Molecularly imprinted polymers (MIP)

Proteomic and genomic sample preparation

Working with difficult matrices

Novel polymers and other substrate materials

Chip-based sample preparation

Autosampler-based sample preparation hardware Sample preparation for biosimilars and biotherapeutic proteins
Offers broad coverage of all sample preparation methods and techniques-including the latest industry developments-within bioanalysisProvides detailed How-To approaches for each technique, making its applications immediately implementableAuthored by an industry analytical chemist who has more than 30 years of experience in all facets of sample preparation, drug analysis, and moreFeatures a thorough and inclusive bibliography of related publications in the field"

Drug Discovery and Evaluation / Pharmacological Assays

Автор: Vogel Hans G.
Название: Drug Discovery and Evaluation / Pharmacological Assays
ISBN: 3540298371 ISBN-13(EAN): 9783540298373
Издательство: Springer
Цена: 23753 р.
Наличие на складе: Поставка под заказ.

Описание: Now expanded and updated to include molecular biology and genetic engineering techniques! The 2nd edition of this successful reference book contains a comprehensive selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic respiratory, renal and immunomodulatory activities. Each of the more than 1000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. The enclosed and fully searchable CD-ROM allows easy identification of specific tests. An appendix with up-to-date guidelines and legal regulations for animal experiments in various countries will help the reader to plan experiments more effectively.

Microbiological Assay for Pharmaceutical Analysis

Автор: Hewitt
Название: Microbiological Assay for Pharmaceutical Analysis
ISBN: 0849318246 ISBN-13(EAN): 9780849318245
Издательство: Taylor&Francis
Рейтинг:
Цена: 53543 р.
Наличие на складе: Поставка под заказ.

Описание: A user-friendly guide for the evaluation of microbiological assays, Microbiological Assay for Pharmaceutical Analysis: A Rational Approach provides a lucid explanation of the sources of error in microbiological assay and helps analysts choose efficient assay designs that will minimize those sources of error. Beginning with a review of the theoretical basis for the quantitative aspects, the author discusses microbiological assay as a branch of pharmaceutical analysis and distinguishes it from biological assay in general. He draws attention to the microbiological aspects that may not be so obvious to the chemical analyst and to the analytical aspects that may not be so obvious to the microologist. The book contains detailed evaluations of assays that illustrate typical experimental designs and addresses how to present a realistic assessment of the best potency estimate from a series of assays. Although there are other valuable books available in this area, they do not address evaluation. Microbiological Assay for Pharmaceutical Analysis: A Rational Approach expands on the guidance given in pharmacopoeias and helps you choose the assay design most appropriate for the purpose of your

Clinical Antimicrobial Assays (Paperback)

Автор: Reeves, D. S.; Wise, R.; Andrews, J. M .; White, L
Название: Clinical Antimicrobial Assays (Paperback)
ISBN: 0199223254 ISBN-13(EAN): 9780199223251
Издательство: Oxford Academ
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Цена: 6327 р.
Наличие на складе: Поставка под заказ.

Описание: In 1978 the forerunner of this book appeared as "Laboratory Methods in Antimicrobial Therapy" (Editors Reeves, Philips, Williams and Wise). This long awaited new volume comprises 19 chapters relevant to the subject of assays and pharmacology of antimicrobials.

Enzyme Assays: A Practical Approach

Название: Enzyme Assays: A Practical Approach
ISBN: 0199638217 ISBN-13(EAN): 9780199638215
Издательство: Oxford Academ
Рейтинг:
Цена: 26212 р.
Наличие на складе: Поставка под заказ.

Описание: Topics include experimental protocols covering photometric, radiometric, HPLC, and electrochemical assays, along with methods for determining enzyme assays after gel electrophoresis. The theory underlying each method is outlined, together with the instrumentation, sensitivity and sources of error.

Drug Discovery and Evaluation / Pharmacological Assays

Автор: Vogel Hans G.
Название: Drug Discovery and Evaluation / Pharmacological Assays
ISBN: 3540714200 ISBN-13(EAN): 9783540714200
Издательство: Springer
Рейтинг:
Цена: 88952 р.
Наличие на складе: Поставка под заказ.

Описание: Offering both cutting-edge and classic pharmacological methods, this new edition to a successful reference offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs.


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