Nociceptin Opioid,97, Gerald Litwack

Автор: J. de Castro; J. Meynadier; Michael Zenz
Название: Regional Opioid Analgesia
ISBN: 9401075433 ISBN-13(EAN): 9789401075435
Издательство: Springer
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Автор: Heath B. McAnally
Название: Opioid Dependence
ISBN: 3319474960 ISBN-13(EAN): 9783319474960
Издательство: Springer
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Описание: The book begins with a public health/epidemiologic examination of the situation, with a systematic view of the problem based on classic (infectious disease) epidemiologic principles applied to this behavioral health issue.

Автор: Abraham Wikler
Название: Opioid Dependence
ISBN: 1468438689 ISBN-13(EAN): 9781468438680
Издательство: Springer
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Описание: A major problem in the treatment of opioid dependence has been the persistence of relapse despite detoxification and enforced prolonged abstention from drug use, with or without conventional psychotherapy and other efforts at rehabilitation.

Автор: Santi M. Spampinato
Название: Opioid Receptors
ISBN: 1493917072 ISBN-13(EAN): 9781493917075
Издательство: Springer
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Описание: Opioid Receptors: Methods and Protocols serves as a comprehensive guide to both key new techniques and established methods for the investigation of genetics, structural biology, transcription, and post-transcriptional events of opioid receptors.

Автор: Ying Xia
Название: Neural Functions of the Delta-Opioid Receptor
ISBN: 3319254936 ISBN-13(EAN): 9783319254937
Издательство: Springer
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Цена: 28734.00 р.
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Описание: This book is the first to summarize the progress of research on neural functions of the the delta opioid receptor (DOR) to date. The book will provide a comprehensive overview of the current state of DOR research and provide a blueprint for future directions.ГЇВїВЅ

Автор: J. de Castro; J. Meynadier; Michael Zenz
Название: Regional Opioid Analgesia
ISBN: 0792301625 ISBN-13(EAN): 9780792301622
Издательство: Springer
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Описание: We are indebted to the authors for introducing the new opioids to regional analgesia with the scientists, who de- veloped the potent short and ultrashort acting opioids with high therapeutic indices, which many researchers dreamt about but never before materialized.

Автор: A.F. Casy; R.T. Parfitt
Название: Opioid Analgesics
ISBN: 0306421305 ISBN-13(EAN): 9780306421303
Издательство: Springer
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Цена: 36570.00 р.
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Описание: The rapidly burgeoning research of the past two decades on agonist-antagonist analgesics and opioid receptors makes this exhaustive review of opioid anal- gesics particularly relevant and timely.

Автор: A.F. Casy; R.T. Parfitt
Название: Opioid Analgesics
ISBN: 1489905871 ISBN-13(EAN): 9781489905871
Издательство: Springer
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Цена: 27950.00 р.
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Описание: The rapidly burgeoning research of the past two decades on agonist-antagonist analgesics and opioid receptors makes this exhaustive review of opioid anal­ gesics particularly relevant and timely. After an introductory chapter the additional 12 chapters begin logically with morphine and congeners (4- epoxymorphinans) and end with opioid receptors. All principal chemical types of centrally acting analgesics (including endogenous opioid-like substances) and their antagonists as well as the mixed agonist-antagonists are treated thoroughly, although not always (and for good reason) in historical (chrono­ logical) order. A chapter on miscellaneous types (atypical structures for the most part) includes the benzimidazoles (etonitazene), aminotetralins (dezocine), tetrahydroisoquinolines (methopholine), and so on. Important aspects and correlations of chemistry, pharmacology, and biochemistry are discussed in depth. Literature citations are numerous. For educators, practicing laboratory scientists, and physicians, this scholarly review by two authors well of opioid analgesics versed in the chemistry, pharmacology, and biochemistry will be informative, stimulating, and thought-provoking. Everette L. May Medical College of Virginia Richmond, VA 23298 v Preface The history of opium predates the written word, although knowledge of its constituents dates back less than 200 years. Over the centuries its popularity for the relief of pain has waxed and waned, until today the opiates are widely recognized as excellent analgesics but with disadvantages that have impaired their use seriously. There is a clear need for a potent analgesic with minimal effects on the respiratory centers and gastrointestinal tract and preferably devoid of dependence liability.

Автор: Michael J Parnham
Название: Non-Opioid Analgesics in the Treatment of Acute Pain
ISBN: 3764356804 ISBN-13(EAN): 9783764356804
Издательство: Springer
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Цена: 11173.00 р.
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Описание: Dipyrone is widely acknowledged to be an effective antipyretic analgesic with an additional intrinsic spasmolytic activity. It has stood the test of time over the last 75 years in many clinical settings throughout the world. Some 20 years ago, however, concern arose over the implications of isolat- ed reports of agranulocytosis following use of dipyrone. Based on these initial cases the Swedish authorities ordered the withdrawal of the drug from the market. Subsequently, dipyrone has been subjected to extensive comparative epidemiological and clinical studies. The results of these in- vestigations have allayed the earlier concerns and have shown dipyrone to be a versatile analgesic drug with an overall risk of serious adverse events lower than most other non-opioid analgesics. Based on these results, the Swedish authorities (Lakemedelsverket) have approved the reintroduc- tion of dipyrone to clinical use as a valuable contribution to pain treat- ment. In connection with this further milestone in the story of the drug, a symposium was held in Stockholm on March 14, 1996, under the chairman- ship of Professor N. Rawal to review the current understanding of the ac- tion, efficacy and safety of dipyrone. The highlights of this Hoechst symposium emphasize particularly the therapeutic basis for the use of dipyrone in the modern treatment of acute post-operative pain. 9 Mode of action of dipyrone Professor K. Brune, M. D. Erlangen, Germany Most non-opioid analgesic drugs are inhibitors of cydo-oxygenase, the en- zyme catalysing the formation of prostaglandins (PGs).

Автор: K.O. Stumpe; Karin Kraft; Alan I. Faden
Название: Opioid Peptides and Blood Pressure Control
ISBN: 3540189351 ISBN-13(EAN): 9783540189350
Издательство: Springer
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Описание: A. , FADEN, K. KRAFr, and K. O. STUMPE Following the discovery of the pentapeptide enkephalins in 1975, a number of endogenous opioid peptides and opiate receptors have been identified. Endogenous opioids and opiate-receptor mechanisms have been implicated in a variety of regulat- ory and dysregulatory functions including analgesia, cardiovascular regulation, shock, hypertension, traumatic spinal cord and brain injury, stroke, immune func- tion, feeding behavior, diuresis, gastrointestinal motility, and respiratory control, among others. Over the past 10 years, many studies have demonstrated a relationship between endogenous opioids and the cardiovascular system under both homeostatic and pathophysiological conditions. Opioids and opiate receptors have been found in various cardioregulatory sites within the brain and spinal cord, as well as in peripheral tissues such as sympathetic ganglia, adrenal gland, and heart. Both endogenous opioids and exogenous opiates have been shown to produce potent cardiovascular effects following central nervous system or systemic administration. Opiate-receptor antagonists have been demonstrated to reverse hypotension from sepsis, hypo- volemia, and anaphylaxis; such studies have been used to infer activity of endogenous opioid systems in shock. Changes in tissue concentrations of endogenous opioids and or opiate receptors have been found after shock and hypertension, further implying a role for opioid systems in the etiology of these conditions. In addition, modification of opiate receptor regulation, receptor binding, or opioid metabolism has also been used to establish a potential role for endogenous opioid systems in cardiovascular control and dyscontrol.

Автор: Zhizhong Z. Pan
Название: Opioid Research
ISBN: 161737329X ISBN-13(EAN): 9781617373299
Издательство: Springer
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Цена: 21661.00 р.
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Описание: Opioid research is one of the multidisciplinary research areas that involve advanced techniques ranging from molecular genetics to neuropharmacology, and from behavioral neuroscience to clinical medicine.