The Poetics and Politics of Alzheimer`s Disease Life-Writing, Martina Zimmermann
Автор: Rudolph Название: Alzheimer`s Disease ISBN: 1439827087 ISBN-13(EAN): 9781439827086 Издательство: Taylor&Francis Рейтинг: Цена: 17149.00 р. 24499.00-30% Наличие на складе: Есть (1 шт.) Описание:
In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer's disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimer's Disease: Targets for New Clinical, Diagnostic, and Therapeutic Strategies provides a detailed synopsis of the current state of the art of diagnostics and therapeutics and identifies emerging technologies and molecules that show promise in the management and treatment of AD.
With contributions from experts drawn from academia, clinical practice, and the biotechnology and pharmaceutical industries, the book explores:
The basis of AD and the role of Aβ oligomers in development of disease
Existing and emerging in vitro biomarker-based methodologies for the diagnosis of AD, focusing on genetic, biochemical, and conformational strategies
In vivo imaging diagnostic approaches
Evolving diagnostic criteria, health regulatory guidelines, biomarkers in clinical trials, and available and emerging therapies
Recent progress in small-molecule disease-modifier drug discovery efforts for AD, specifically in the areas of Aβ, tau, and emerging neuroprotective/neurorepair approaches
How a case study of AD raises issues regarding clinical and pathologic criteria, risk factors, and the amyloid hypothesis
The molecular conformational factors that govern the pathogenicity of aggregating proteins, and how these factors could represent new targets for disease-modifying therapies
The latest epidemiological, pathological, biochemical, and behavioral studies that may shed some light on the risk of developing AD and similar dementias after traumatic brain injury
Examining current hypotheses and suggesting possible new approaches to therapeutic clinical applications, this volume paves the way for a robust pipeline of therapeutics to combat not only AD, but a whole host of other neurodegenerative diseases.
Описание: Due to rapidly aging populations, the number of people worldwide experiencing dementia is increasing, and the projections are grim. Despite billions of dollars invested in medical research, no effective treatment has been discovered for Alzheimer`s disease, the most common form of dementia. The Alzheimer Conundrum exposes the predicaments embedded
Автор: Davis Название: Alzheimer Talk, Text and Context ISBN: 1403935327 ISBN-13(EAN): 9781403935328 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This collection augments clinical inventories of Alzheimer`s studies with an emphasis on the ways caregivers and researchers can focus on communication enhancement and person-centered care. The contributors examine discourse boundaries and social relationships, gender-cued interaction and life-course analysis, online text by and about Alzheimer`s
Автор: de la Torre Название: Alzheimer`s Turning Point ISBN: 3319340565 ISBN-13(EAN): 9783319340562 Издательство: Springer Рейтинг: Цена: 12577.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This compelling text provides an overview of the available technology for early detection and therapeutic management of vascular risk factors to Alzheimer’s before severe cognitive impairment symptoms appear. Chapters bring the reader from the trackless clinical research that has characterized Alzheimer’s progress for the last 20 years, to a nexus of new ideas and concepts that can change our outlook of this dementia. In-depth examinations of various hypotheses, preventive measures, current and prospective treatments are openly and clearly explored. The author discusses in depth his proposal of the vascular hypothesis of Alzheimer's disease which has become a mother-lode for basic and clinical studies and a key approach to the prevention of this dementia.Alzheimer’s Turning Point offers professionals, students and those looking to learn more about this disorder a fresh clinical perspective of this devastating disease.
Описание: The number of patients with dementia is rising in proportion to the aging of our population; therefore, by 2050 the prevalence of Alzheimer's disease is expected to triple, risking the integrity of the entire U.S. healthcare economy. More NIH dollars are spent on Alzheimer's disease research than on any other neurological disease and our available fund of information has commensurately accelerated. Whereas 30 years ago little distinction was made between different forms of dementia, clinicians now distinguish multiple degenerative and vascular syndromes, each with their own etiologic, therapeutic and prognostic implications. New genetic insights reach the popular press on a regular basis. Consequently Alzheimer's disease (and related disorders) has become a special concern to the majority of the population whose main avenue of care lies with the primary care physician. The primary care physician (general internist, family practitioner, nurse practitioner), geriatrician, and geriatric psychiatrist are the target audiences for this book; in short anyone who is not a neurological expert who provides dementia-related care. As the primary care physician is the target audience for this title, the volume begins with a discusion of how to produce an effective diagnosis through a series of precise, easy- to- follow steps. Additional sections detail the current research state of each of the major individual dementia diseases that the general clinician frequently encounters. The last section procides a clinically focused 'how to' guide for treatment including symptom-directed pharmacotherapy, as well as an up-to-date summary of ongoing major therapeutic trials and an assessment non-pharmacological management issues such as driving and end-of- life considerations. Aiming to be clear, consice and practical, this volume provides the essential information in dementia related care, from disease diagnosis to symptom management. Because it uses the most up-to-date dementia research available, this volume will become a close companion of the primary care physician, who seeks direct answers to the common questions and issues that arise in the diagnosis and management of patients with dementia.
Автор: Derreumaux Philippe Название: Alzheimer`s Disease: Insights into Low Molecular Weight and ISBN: 1848167547 ISBN-13(EAN): 9781848167544 Издательство: World Scientific Publishing Рейтинг: Цена: 22968.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Alzheimer`s disease is the most common form of senile dementia, affecting more than 24 million people worldwide. This book provides a panoramic view across in vitro and in vivo studies along with computer simulations, designed to increase the readers` understanding of oligomerisation and fibril formation.
Автор: Suzanne Craft Название: Diabetes, Insulin and Alzheimer`s Disease ISBN: 3642262813 ISBN-13(EAN): 9783642262814 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This text provides a broad survey of the role of insulin in the brain. And it discusses the mechanisms through which insulin dysregulation contributes to the development of cognitive impairment and late-life neurodegenerative disease.
Автор: Dennis J. Selkoe; Antoine Triller Название: Synaptic Plasticity and the Mechanism of Alzheimer`s Disease ISBN: 3642095194 ISBN-13(EAN): 9783642095191 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A biochemical hypothesis - that Alzheimer`s disease (AD) is a progressive cerebral amyloidosis caused by the aggregation of the amyloid b-protein (Ab) - preceded and enabled the discovery of etiologies.
Автор: Abraham Fisher; Maurizio Memo; Fabrizio Stocchi; I Название: Advances in Alzheimer`s and Parkinson`s Disease ISBN: 1441944230 ISBN-13(EAN): 9781441944238 Издательство: Springer Рейтинг: Цена: 43184.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume contains the proceedings of the 2005 ADPD conference and is unique in that it deals not only with issues related individually to Alzheimer`s disease and Parkinson`s disease, but also with the integration of these and other related diseases.
Автор: Budson Название: The Handbook of Alzheimer`s Disease and Other Dementias ISBN: 1118672852 ISBN-13(EAN): 9781118672853 Издательство: Wiley Рейтинг: Цена: 4744.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This is a broad-ranging review of the current research on Alzheimer`s disease and other dementias from both basic neuroscience and clinical perspectives. It provides scientists and medical professionals with an extensive introduction and an up-to-date review of cutting-edge scientific advances in a single volume.
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