Gene therapy for hiv and chronic infections, 

Автор: Edmund C. Lattime
Название: Gene Therapy of Cancer,
ISBN: 0123942950 ISBN-13(EAN): 9780123942951
Издательство: Elsevier Science
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Цена: 23244.00 р.
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Описание: Gene therapy as a treatment for cancer is at a critical point in its evolution. This book offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells.

Автор: Escors
Название: Lentiviral Vectors and Gene Therapy
ISBN: 3034804016 ISBN-13(EAN): 9783034804011
Издательство: Springer
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Цена: 9141.00 р.
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Описание: Gene therapy was conceived during the early and mid part of the 20th century. At first, it was considered a revolutionary biomedical procedure, which could potentially cure any disease for which the molecular bases were understood. Since then, gene therapy has gone through many stages and has evolved from a nearly unrealistic perspective to a real life application. Clinical efficacy in humans was demonstrated at the beginning of this century after its successful application in small-scale clinical trials to cure severe immunodeficiency in children. However, their successes were overshadowed some time later by the occurrence of vector-related leukaemia in a number of treated children. It is in this context that lentiviral vectors have appeared, with improved efficiency and, possibly, increased biosafety. Very recently, the first clinical trials with lentivectors have been carried out with some success. This Brief firstly defines gene therapy, and places lentivectors within this fascinating therapeutic strategy. Then follows a comprehensive description of the development of retroviral and lentiviral vectors and how to specifically target distinct cell types and tissues. The authors also discuss the application of lentivector gene therapy for the treatment of cancer and autoimmune diseases, ending with the application of lentivectors in human gene therapy clinical trials.

Автор: Merten
Название: Viral Vectors for Gene Therapy
ISBN: 161779094X ISBN-13(EAN): 9781617790942
Издательство: Springer
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Цена: 22359.00 р.
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Описание: The huge potential for gene therapy to cure a wide range of diseases has led to high expectations and a great increase in research efforts in this area, particularly in the study of delivery via viral vectors, widely considered to be more efficient than DNA transfection.  In Viral Vectors for Gene Therapy: Methods and Protocols, experts in the field present a collection of their knowledge and experience featuring methodologies that involve virus production, transferring protocols, and evaluating the efficacy of gene products. While thoroughly covering the most popular viral vector systems of adenovirus, retrovirus, and adeno-associated virus, this detailed volume also explores less common viral vector systems such as baculovirus, herpes virus, and measles virus, the growing interest in which is creating a considerable demand for large scale manufacturing and purification procedures.  Written in the highly successful Methods in Molecular Biology™ series format, many chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and vital tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Viral Vectors for Gene Therapy: Methods and Protocols provides basic principles accessible to scientists from a wide variety of backgrounds for the development of gene therapy viral products that are safe and effective.

Автор: Louis Weinstein; David Schlossberg
Название: Infections of the Nervous System
ISBN: 1461397006 ISBN-13(EAN): 9781461397007
Издательство: Springer
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Цена: 16769.00 р.
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Описание: Dr. David Schlossberg presents his fifth volume in the series Clinical Topics in Infectious Disease, Infections of the Nervous System. This edited monograph brings together the leading authorities in infectious disease, neurology, and radiology to review the diagnosis and treatment of all major neurological infections.

Автор: Gerhard Bauer; Joseph S. Anderson
Название: Gene Therapy for HIV
ISBN: 1493904337 ISBN-13(EAN): 9781493904334
Издательство: Springer
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Цена: 7685.00 р.
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Автор: Yuti Chernajovsky; Paul D. Robbins
Название: Gene Therapy for Autoimmune and Inflammatory Diseases
ISBN: 3034803060 ISBN-13(EAN): 9783034803069
Издательство: Springer
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Цена: 26120.00 р.
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Описание: This text addresses the latest advances in viral and non-viral vectors as well as novel targets and methods for the treatment of autoimmune and inflammatory disease. Its main focus is on pre-clinical testing with up-to-date clinical trials.

Автор: Clay Smith
Название: Gene Therapy for HIV Infection
ISBN: 3662118238 ISBN-13(EAN): 9783662118238
Издательство: Springer
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Цена: 6986.00 р.
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Описание: These strategies fall into two general categories, genetic modification of cells in order to elicit an immune response against HIV and genetic modification of the target cells of HIV infection in order to block HIV expression and reproduction.

Автор: Phillip H. Factor
Название: Gene Therapy for Acute and Acquired Diseases
ISBN: 1461356687 ISBN-13(EAN): 9781461356684
Издательство: Springer
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Цена: 13974.00 р.
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Описание: In recent years much enthusiasm and energy has been directed toward the development of human gene therapies, especially for inherited conditions and cancers.