Trichloroethylene: Toxicity and Health Risks, Kathleen M. Gilbert; Sarah J. Blossom
Автор: Prasad M.N., Strzalka Kazimierz Название: Physiology and Biochemistry of Metal Toxicity and Tolerance in Plants ISBN: 1402004680 ISBN-13(EAN): 9781402004681 Издательство: Springer Рейтинг: Цена: 19565.00 р. 27950.00-30% Наличие на складе: Есть (1 шт.) Описание: The aim of this book is to give an overview of the most important aspects of physiological and biochemical basis for metal toxicity and tolerance in plants. The book is expected to serve as a reference to university and college teachers, students of plant sciences, environmental biology, environmental biotechnology, agriculture, horticulture, forestry, plant molecular biology, and genetics.
Автор: Eskes Название: Validation of Alternative Methods for Toxicity Testing ISBN: 3319338242 ISBN-13(EAN): 9783319338248 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and transcriptomics, and for methods derived from pathway-based concepts in toxicology. Validation of Alternative Methods for Toxicity Testing is divided into two sections, in the first, practical insights are given on the state-of-the-art and on approaches that have resulted in successfully validated and accepted alternative methods. The second section focuses on the evolution of validation principles and practice that are necessary to ensure fit-for-purpose validation that has the greatest impact on international regulatory acceptance of alternative methods. In this context validation needs to keep pace with the considerable scientific advancements being made in toxicology, the availability of sophisticated tools and techniques that can be applied in a variety of ways, and the increasing societal and regulatory demands for better safety assessment. This book will be a useful resource for scientists in the field of toxicology, both from industry and academia, developing new test methods, strategies or techniques, as well as Governmental and regulatory authorities interested in understanding the principles and practicalities of validation of alternative methods for toxicity testing.
Автор: Balls, Michael; Combes, Robert D.; Bhogal, Nirmala (Eds.) Название: New Technologies for Toxicity Testing ISBN: 1461430542 ISBN-13(EAN): 9781461430544 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Поставка под заказ.
Описание: The central theme running through this volume on New Technologies for Toxicity Testing is the development and application of advanced techniques for cell and tissue culture, as well as new markers and endpoints of toxicity, as alternatives to the traditional paradigm of relying on data from laboratory animal tests to undertake labelling and risk assessment. Of course, many of the techniques and methods described in this volume are in the early stages of development, and much work will be needed to ensure their further improvement, optimisation and validation. However, we are confident that this will be achieved and that, just as with the in vitro assays that were validated and granted regulatory acceptance over the last decade, these, and many other new, advanced methods, will likewise become part of the toxicologist’s improved toolbox for coping with increasingly stringent and numerous regulatory requirements and test chemicals, while placing less reliance on traditional testing paradigms.
Автор: Andrew F. Olshan; Donald R. Mattison Название: Male-Mediated Developmental Toxicity ISBN: 1461357640 ISBN-13(EAN): 9781461357643 Издательство: Springer Рейтинг: Цена: 28734.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of an international conference held in Pittsburgh, Pennsylvania, September 16-19, 1992
Автор: Peter Greaves Название: Histopathology of Preclinical Toxicity Studies, ISBN: 0444538569 ISBN-13(EAN): 9780444538567 Издательство: Elsevier Science Рейтинг: Цена: 25096.00 р. Наличие на складе: Поставка под заказ.
Описание: Describes the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. This reference is suitable for those involved in drug safety evaluation, including pathologists, toxicologists, and pharmacologists.
Автор: Benfenati Название: In Silico Methods for Predicting Drug Toxicity ISBN: 1493936077 ISBN-13(EAN): 9781493936076 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This detailed volume explores in silico methods forpharmaceutical toxicity by combiningthe theoretical advanced research with the practical application of the tools.Beginning with a section covering sophisticated models addressing the bindingto receptors, pharmacokinetics and adsorption, metabolism, distribution, andexcretion, the book continues with chapters delving into models for specifictoxicological and ecotoxicological endpoints, as well as broad views of themain initiatives and new perspectives which will very likely improve our way ofmodelling pharmaceuticals. Written for the highly successful Methods in Molecular Biology series,chapters include the kind of detailed implementation advice that is key forachieving successful research results.Authoritative and practical, In Silico Methods for Predicting DrugToxicity offers the advantage of incorporating data and knowledge fromdifferent fields, such as chemistry, biology, -omics, and pharmacology, toachieve goals in this vital area of research.
Описание: International Symposium. IFPMA Symposium, Geneva 30-31 October 1984
Автор: Bernard Robaire; Barbara F. Hales Название: Advances in Male Mediated Developmental Toxicity ISBN: 1461348293 ISBN-13(EAN): 9781461348290 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
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