Activation of Hormone and Growth Factor Receptors, Michael N. Alexis; Constantin E. Sekeris
Автор: Stenmark Harald Название: Phosphoinositides in Subcellular Targeting and Enzyme Activation ISBN: 3540009507 ISBN-13(EAN): 9783540009504 Издательство: Springer Рейтинг: Цена: 1092.00 р. Наличие на складе: Есть (3 шт.) Описание: Cells of the immune system are activated by a variety of stimuli that are derived from other cells, ingested material or from invading microorganisms. This issue of CTMI focuses on the mechanisms of phosphoinositide-mediated protein recruitment to intracellular membranes.
Автор: Luck Martin Название: Hormones: A Very Short Introduction ISBN: 0199672873 ISBN-13(EAN): 9780199672875 Издательство: Oxford Education Рейтинг: Цена: от 1138.00 р. Наличие на складе: Есть
Описание: Hormones are vital to the workings of the body, and while many people are aware of what hormones do, few have an appreciation of the nature and importance of the endocrine system. In this Very Short Introduction, Martin Luck explains what hormones are, what they do, where they come from, and how they work.
Описание: A role for vitamin A in living organisms has been known throughout human history. In the last 100 years, the biochemical nature of vitamin A and its active derivative, retinoic acid, its physiological impact on growth processes and the essential details of its mechanism of action have been revealed by investigations carried out by researchers using vertebrate and more recently invertebrate models to study a multiplicity of processes and conditions, encompassing embryogenesis, postnatal development to old age. A wealth of intercellular interactions, intracellular signaling systems and molecular mechanisms have been described and the overall conclusion is that retinoic acid is essential for life. This book series, with chapters authored by experts in every aspect of this complex field, unifies the knowledge base and mechanisms currently known in detailed, engaging, well-illustrated, focused chapters that synthesize information for each specific area. In view of the recent explosion in this field, it is timely to publish a contemporary, comprehensive, book series recapitulating the most exciting developments in the field and covering fundamental research in molecular mechanisms of vitamin A action, its role in physiology, development and continued well-being and the potential of vitamin A derivatives and synthetic mimetics to serve as therapeutic treatments for cancers and other debilitating human diseases. VOLUME I: Here, we present the first volume of a multi-volume series on Retinoic Acid Signaling that will cover all aspects of this broad and diverse field. One aim of Volume I is to present a compilation of topics related to the biochemistry of nuclear retinoic acid receptors, from their architecture when bound to DNA and associated with their coregulators to their ability to regulate target gene transcription. A second aim is to provide insight into recent advances that have been made in identifying novel targets and non-genomic effects of retinoic acid. Volume I is divided into ten chapters contributed by prominent experts in their respective fields. Each chapter starts with the history of the area of research. Then, the key findings that contributed to development of the field are described, followed by a detailed look at key findings and progress that are being made in current, ongoing research. Each chapter is concluded with a discussion of the relevance of the research and a perspective on missing pieces and lingering gaps that the author recommends will be important in defining future directions in vitamin A research.
Автор: Stephen W. Russell; Siamon Gordon Название: Macrophage Biology and Activation ISBN: 3642773796 ISBN-13(EAN): 9783642773792 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The aspects covered in this volume have been selected to provide an overview of subject areas that either have recently become much better understood or hold the promise of new levels of understanding as they are developed in the future.
Описание: This book investigates the function and mechanism of a newly discovered heme-thiolate peroxygenase, AaeAPO. Featuring clear illustrations with original research data, it demonstrates that the peroxygenase catalyzes a wide range of reactions.
Автор: Arthur Martell Название: Oxygen Complexes and Oxygen Activation by Transition Metals ISBN: 1461282632 ISBN-13(EAN): 9781461282631 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This monograph consists of manuscripts, summary statements, and poster abstracts submitted by invited speakers and poster contributors who participated in the symposium "Oxygen Complexes and Oxygen Activation by Transition Metals," held March 23-26, 1987, at Texas A&M University.
Автор: Rast Название: Immune Receptors ISBN: 1617791385 ISBN-13(EAN): 9781617791383 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Immunology has made significant progress in the past decade, driven forward by rapidly advancing technology and a renewed interest in the vast realm of innate immunity. The receptors that mediate these functions are at the front lines of both protective and regulative roles of the immune system. In Immune Receptors: Methods and Protocols, expert researchers present a variety of experimental approaches to the characterization of immune receptors and the cell biology that mediates their functions. These include imaging techniques that aim to understand receptor localization and trafficking, techniques to measure receptor-ligand interactions, strategies to identify novel ligands and methods to analyze downstream receptor signaling, as well as strategies for genomic and proteomic characterization of receptor repertoires. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Immune Receptors: Methods and Protocols offers technical descriptions and protocols that will be useful both to investigators who are interested in carrying out these procedures and to those who seek a deeper understanding of the bench science that lies behind the immunology literature.
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