The Big Book on Small Heat Shock Proteins, Robert M. Tanguay; Lawrence E. Hightower
Автор: Alexzander A. A. Asea; Punit Kaur; Stuart K. Calde Название: Heat Shock Proteins and Plants ISBN: 331946339X ISBN-13(EAN): 9783319463391 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Heat Shock Proteins and Plants provides the most up-to-date and concise reviews and progress on the role of heat shock proteins in plant biology, structure and function and is subdivided into chapters focused on Small Plant HSPs (Part I), Larger Plant HSPs (Part II) and HSPs for Therapeutic Gain (Part III). This book is written by eminent leaders and experts from around the world and is an important reference book and a must-read for undergraduate, postgraduate students and researchers in the fields of Agriculture, Botany, Crop Research, Plant Genetics and Biochemistry, Biotechnology, Drug Development and Pharmaceutical Sciences.
Автор: Alfred Wittinghofer Название: Ras Superfamily Small G Proteins: Biology and Mechanisms 1 ISBN: 3709118050 ISBN-13(EAN): 9783709118054 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This first of two volumes provides a general overview of the genetics, structure, mechanism and regulation of the Ras superfamily proteins and describes in detail the signaling pathways and processes regulated by specific members of this family. The focus of this first volume is on the Rho and Ras subfamily of small G proteins. Renowned scientists provide insights into the biochemistry of the classical and non-classical small G-protein family members, their spatio-temporal regulation, their effectors and their roles in health and disease. Together with Volume 2, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It is intended for graduates and professors in biochemistry and cell biology already working on small G-proteins (small GTPases), but also offers an extremely valuable resource for those readers who are new to the field.
Автор: Alfred Wittinghofer Название: Ras Superfamily Small G Proteins: Biology and Mechanisms 2 ISBN: 3319077600 ISBN-13(EAN): 9783319077604 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This second of two volumes discusses subfamily proteins which function in molecular and vesicular transport mechanisms inside the cell. In this volume the focus lies on the Rab, Ran and Arf subfamily members. As in Volume 1, the book is written by international renowned scientists in the field of small G-proteins. In elaborate reviews, biochemistry, structure, function and G-protein - effector interactions are described. Together with Volume 1 this book provides an comprehensive state-of-the-art work on small G-proteins (GTPases). It is written for Graduates and Professors in Biochemistry and Cell Biology interested in the mechanism and function of small G-proteins but are extremely valuable for those who want to move into the field.
Автор: Donev, Rossen Название: Advances in Protein Chemistry and structural biology ISBN: 0128123907 ISBN-13(EAN): 9780128123904 Издательство: Elsevier Science Рейтинг: Цена: 20043.00 р. Наличие на складе: Поставка под заказ.
Описание:
Chromatin Proteins and Transcription Factors as Therapeutic Targets, the latest volume in the Advances in Protein Chemistry and Structural Biology series is an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics.
Автор: Williamson, Mike Название: How proteins work ISBN: 0815344465 ISBN-13(EAN): 9780815344469 Издательство: Taylor&Francis Рейтинг: Цена: 12248.00 р. Наличие на складе: Поставка под заказ.
Описание:
How Proteins Work is an up-to-date and authoritative account of protein function in living systems, explained within the governing parameters of physics, chemistry, and evolution. This text will enable advanced undergraduate students in biochemistry and biophysics to understand the relationships among protein function, structure, and dynamics. It will also serve as a valuable resource for graduate students and researchers looking for a reference on the fundamentals underlying protein function.
By providing an integrated view of proteins at both a cellular and systemic level, this textbook shows how evolution drives proteins to adopt domain structures that combine to achieve biological outcomes. The association of proteins into dimers, molecular machines, and multi-enzymatic complexes enables them to achieve catalytic and functional efficiency.
Автор: McAlpine Название: Heat Shock Protein Inhibitors ISBN: 3319326058 ISBN-13(EAN): 9783319326054 Издательство: Springer Рейтинг: Цена: 36570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
Автор: Alexzander A. A. Asea; Bente K. Pedersen Название: Heat Shock Proteins and Whole Body Physiology ISBN: 9048133807 ISBN-13(EAN): 9789048133802 Издательство: Springer Рейтинг: Цена: 28734.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This up-to-date review focuses on the crucial role heat shock proteins play in human physiology. By introducing the mechanisms by which heat shock proteins modulate human disease and pathophysiology, this volume reveals its biological significance to the host.
Автор: Alexzander A. A. Asea; Bente K. Pedersen Название: Heat Shock Proteins and Whole Body Physiology ISBN: 9400731310 ISBN-13(EAN): 9789400731318 Издательство: Springer Рейтинг: Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This up-to-date review focuses on the crucial role heat shock proteins play in human physiology. By introducing the mechanisms by which heat shock proteins modulate human disease and pathophysiology, this volume reveals its biological significance to the host.
Описание: This book reviews current progress on heat shock proteins in the brain and their implications for neurodegenerative diseases, neuroprotection, aging and control of life span. It features contributions from laboratories from major universities around the world.
Автор: Michael B. Evgen`ev; David G. Garbuz; Olga G. Zats Название: Heat Shock Proteins and Whole Body Adaptation to Extreme Environments ISBN: 9401792348 ISBN-13(EAN): 9789401792349 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: For many years, the authors have investigated the adaptive role of heat shock proteins (HSPs) in different animals, including the representatives of homothermic and poikilothermic organisms that inhabit regions with contrasting thermal conditions. This book will summarize the data accumulated in the course of these studies and describe the general molecular mechanisms underlying the adaptation of various organisms to aggressive environments. We also concentrate on different evolutionary trends characteristic for HSP systems in the course of adaptation to fluctuating environmental conditions. In addition, we describe the peculiarities in the regulatory regions of heat shock genes necessary for fine tuning of these systems providing the adaptation to adverse conditions. Special emphasis is given to the role of mobile elements in the evolution and functioning of various groups of HSP genes. The book combines the results of field studies and laboratory analysis of stress genes systems.
Автор: Guang Zhu Название: NMR of Proteins and Small Biomolecules ISBN: 3642429041 ISBN-13(EAN): 9783642429040 Издательство: Springer Рейтинг: Цена: 36570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: J. L. Stark R. Powers Application of NMR and Molecular Docking in Structure-Based Drug Discovery.- O. Vinogradova J. Qin NMR as a Unique Tool in Assessment and Complex Determination of Weak Protein-Protein Interactions.- K. Chen N. Tjandra The Use of Residual Dipolar Coupling in Studying Proteins by NMR.- H. Li H. Sun NMR Studies of Metalloproteins.- R. Ishima Recent Developments in 15N NMR Relaxation Studies that Probe Protein Backbone Dynamics.- T. Qureshi N. K. Goto Contemporary Methods in Structure Determination of Membrane Proteins by Solution NMR.- X. Zhao Protein Structure Determination by Solid-State NMR.- K. H. Sze Q. Wu H. S. Tse G. Zhu Dynamic Nuclear Polarization: New Methodology and Applications.
Автор: Alexzander A.A. Asea; Naif N. Almasoud; Sunil Kris Название: Heat Shock Protein-Based Therapies ISBN: 3319172107 ISBN-13(EAN): 9783319172101 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Contents
Contributors Preface SECTION I: HEAT SHOCK PROTEIN HSP27-BASED THERAPIES 1 HSP27 as a Therapeutic Target of Novel Inhibitors and Dietary Phytochemicals in Cancer Elena Arechaga-Ocampo and Cйsar Lуpez-Camarillo 2 Heat Shock Protein 27 (HSP27, HSPB1) is Up-Regulated by Targeted Agents and Confers Resistance to Both Targeted Drugs and Chemotherapeutics Daniele Musiani, John D. Konda, Simona Pavan, Erica Torchiaro, Jessica Erriquez, Martina Olivero and Maria F. Di Renzo 3 Heat Shock Proteins and Cancer: Plant Based Therapy Evren Цnay-Ucar SECTION II: HEAT SHOCK PROTEIN HSP60-BASED THERAPIES 4 Chaperonotherapy for Alzheimer's Disease: Focusing on HSP60 Francesco Cappello, Antonella M. Gammazza, Silvia Vilasi, Maria G. Ortore, Pier L. San-Biagio, Claudia Campanella, Andrea Pace, Antonio P. Piccionello, Giulio Taglialatela, Everly C. De Macario and Alberto J. l. Macario 5 Secreted and Circulating Cell Stress Proteins in the Periodontal Diseases Brian Henderson, Nikos Donos, Luigi Nibali and Frank Kaiser SECTION III: HEAT SHOCK PROTEIN HSP70-BASED THERAPIES 6 The Role of Heat Shock Protein 70 in Infection and Immunity Jose Rey-Ladino, Abiola Senok, Abdullah Sarkar and Ahlam Al Shedoukhy 7 Potential Cytoprotective Effects of Heat Shock Proteins to Skeletal Muscle John P. Vardiman, Philip M. Gallagher and Jacob A. Siedlik 8 Heat Shock Proteins in Triple-Negative Breast Cancer (TNBC) TreatmentPunit Kaurunit Kaur, Tarundeep arundeep Singh, Moses Galukandealukande, Sunil Krishnanrishnan and Alexzander A. A. Asealexzander Asea 9 Heat Shock Proteins in Multiple Sclerosis Pathogenesis: Friend or Foe? Rosaria Tinnirello, Giuseppina Turturici, Gabriella Sconzo, Walter Spinello, Alexzander A. A. Asea and Fabiana Geraci
10 New Indications for HSP90 and HSP70 Inhibitors as Antiviral Drugs Matthew K. Howe and Timothy A. J. Haystead 11 Potential Applications of Nanoparticles for Hyperthermia Caio C. Quini and Sunil Krishnan SECTION IV: HEAT SHOCK PROTEIN HSP90-BASED THERAPIES 12 Gene Therapy Against HSP90: Glucocorticoid Receptor-Assisted Cancer Treatment Susanta S. Adhikari, Sujan K. Mondal and Rajkumar Banerjee 13 Potential of HSP90 Inhibitors to Treat Neurofibromatosis-Related Tumors Jeremie Vitte and Marco Giovannini 14 Role of Heat Shock Protein 90 in the Cause of Various Diseases: A Potential Therapeutic Target Subhankar Paul 15 HSP90 Inhibitor-Based Strategies for Cancer Therapy: Advancing Toward Clinical Impact David A. Proia and Richard C. Bates 16 Molecular Survival Strategies of Organisms: HSP and Small Molecules for Diagnostics and Drug Development Andreas Kirschning, Johanna-Gabriela Walter, Frank Stahl, Emilia Schax, Thomas Scheper, Pooyan Aliuos and Carsten Zeilinger 17 Targeting Heat Shock Proteins in Colorectal Cancer Sheah L. Lee, Nina C. Dempsey-Hibbert, Dale Vimalachandran, Terence D. Wardle, Paul Sutton and John H. H. Williams Index
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