The subject of this volume is a comprehensive examination of the biochemistry and biology of all classes of known PAS proteins, with the intention that readers will find insight into their own work and ideas from study of the multitude of PAS protein functions. PAS proteins control numerous physiological and developmental events, and span phylogeny from bacteria to man. Bacterial and plant PAS proteins act as sensors of environmental stimuli, including light, oxygen, and energy status.
Not surprising, given these roles, there is intense investigation of the roles of bHLH-PAS proteins in issues of human health including: (1) cancer induction, (2) cancer growth and vascularity, (3) birth defects, including Down syndrome, (4) appetite control and obesity, (5) sleep rhythm disorders, and (6) mental health disorders such as social interactions and learning.
PAS proteins encompass many fields of biology, and scientists who work in these fields (circadian rhythms, oxygen regulation, toxin metabolism, bacterial sensors, and development) are an audience, particularly those who actively work on PAS proteins and researchers interested in transcriptional control, signal transduction, and evolution.
Автор: K.R. Harrap; W. Davis; A.H. Calvert Название: Cancer Chemotherapy and Selective Drug Development ISBN: 089838673X ISBN-13(EAN): 9780898386738 Издательство: Springer Рейтинг: Цена: 44582.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the 10th Anniversary Meeting of the Coordinating Committee for Human Tumour Investigations, Brighton, England (24-28 October 1983)
Автор: Singh Shree Ram Название: MicroRNA in Development and in the Progression of Cancer ISBN: 1489980644 ISBN-13(EAN): 9781489980649 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: miRNAs are a class of endogenous, small non-protein coding RNA molecules (~ 22 nucleotides) which are novel post-transcriptional regulators of gene expression. Since we have hundreds of miRNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest that miRNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF-? and EGFR. Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease. Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many miRNAs in several cancer initiating cells. Several miRNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in self-renewal, differentiation, chemoresistance and tumorigenesis. The volume will give a comprehensive account of important advancements in the area of miRNAs and cancer.
Описание: Heat Shock Proteins and maternal contribution to oogenesis and early embryogenesis.- The unmysterious roles of HSP90: Ovarian biology and autoantibodies.- The role of heat shock factors in mammalian spermatogenesis.- Heat shock protein A2 (HSPA2): Regulatory roles in germ cell development and sperm function.- The potential functions of small heat shock proteins in the uterine musculature during pregnancy.- The role of HSP70 in the regulation of autophagy in gametogenesis, pregnancy and parturition.- Roles of Grp78 in female mammalian reproduction.
Автор: Shree Ram Singh; Pranela Rameshwar Название: MicroRNA in Development and in the Progression of Cancer ISBN: 1493944916 ISBN-13(EAN): 9781493944910 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease.Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy.
Автор: K.R. Harrap; W. Davis; A.H. Calvert Название: Cancer Chemotherapy and Selective Drug Development ISBN: 1461338395 ISBN-13(EAN): 9781461338390 Издательство: Springer Рейтинг: Цена: 30606.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the 10th Anniversary Meeting of the Coordinating Committee for Human Tumour Investigations, Brighton, England (24-28 October 1983)
Автор: Howard D. Lipshitz Название: Genes, Development and Cancer ISBN: 1461347467 ISBN-13(EAN): 9781461347460 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Lewis` research papers are published within one volume- Papers are organized into sections that reflect the focus of the research- Commentaries by Howard Lipshitz highlight key methods and results by explaining the science so it is accessible to upper-level undergraduates, graduate students, and professional researchers
Автор: Walter Doerfler; Petra B?hm Название: DNA Methylation: Development, Genetic Disease and Cancer ISBN: 3642068308 ISBN-13(EAN): 9783642068300 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: It has become apparent that the genomes of many organisms are characterized by unique patterns of DNA methylation which can differ from genome segment to genome segment and cell type to cell type.
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