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RUNX Proteins in Development and Cancer, Yoram Groner; Yoshiaki Ito; Paul Liu; James C. Nei


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Автор: Yoram Groner; Yoshiaki Ito; Paul Liu; James C. Nei
Название:  RUNX Proteins in Development and Cancer
ISBN: 9789811032318
Издательство: Springer
Классификация:



ISBN-10: 9811032319
Обложка/Формат: Hardcover
Страницы: 515
Вес: 1.37 кг.
Дата издания: 23.03.2017
Серия: Advances in Experimental Medicine and Biology
Язык: English
Размер: 265 x 187 x 36
Основная тема: Biomedicine
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy.The pleiotropic effects of RUNX in development are mirrored in cancer, where RUNX genes can function as oncogenes that collaborate strongly with Myc family oncogenes or as tumour suppressor genes.


PAS Proteins: Regulators and Sensors of Development and Physiology

Автор: Stephen T. Crews
Название: PAS Proteins: Regulators and Sensors of Development and Physiology
ISBN: 1461351154 ISBN-13(EAN): 9781461351153
Издательство: Springer
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Цена: 13974.00 р.
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Описание:

The subject of this volume is a comprehensive examination of the biochemistry and biology of all classes of known PAS proteins, with the intention that readers will find insight into their own work and ideas from study of the multitude of PAS protein functions. PAS proteins control numerous physiological and developmental events, and span phylogeny from bacteria to man. Bacterial and plant PAS proteins act as sensors of environmental stimuli, including light, oxygen, and energy status.

Not surprising, given these roles, there is intense investigation of the roles of bHLH-PAS proteins in issues of human health including: (1) cancer induction, (2) cancer growth and vascularity, (3) birth defects, including Down syndrome, (4) appetite control and obesity, (5) sleep rhythm disorders, and (6) mental health disorders such as social interactions and learning.

PAS proteins encompass many fields of biology, and scientists who work in these fields (circadian rhythms, oxygen regulation, toxin metabolism, bacterial sensors, and development) are an audience, particularly those who actively work on PAS proteins and researchers interested in transcriptional control, signal transduction, and evolution.

Cancer Chemotherapy and Selective Drug Development

Автор: K.R. Harrap; W. Davis; A.H. Calvert
Название: Cancer Chemotherapy and Selective Drug Development
ISBN: 089838673X ISBN-13(EAN): 9780898386738
Издательство: Springer
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Цена: 44582.00 р.
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Описание: Proceedings of the 10th Anniversary Meeting of the Coordinating Committee for Human Tumour Investigations, Brighton, England (24-28 October 1983)

MicroRNA in Development and in the Progression of Cancer

Автор: Singh Shree Ram
Название: MicroRNA in Development and in the Progression of Cancer
ISBN: 1489980644 ISBN-13(EAN): 9781489980649
Издательство: Springer
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Цена: 23757.00 р.
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Описание: miRNAs are a class of endogenous, small non-protein coding RNA molecules (~ 22 nucleotides) which are novel post-transcriptional regulators of gene expression. Since we have hundreds of miRNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest that miRNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF-? and EGFR. Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease. Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many miRNAs in several cancer initiating cells. Several miRNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in self-renewal, differentiation, chemoresistance and tumorigenesis. The volume will give a comprehensive account of important advancements in the area of miRNAs and cancer.

The Role of Heat Shock Proteins in Reproductive System Development and Function

Автор: Daniel J. MacPhee
Название: The Role of Heat Shock Proteins in Reproductive System Development and Function
ISBN: 3319514083 ISBN-13(EAN): 9783319514086
Издательство: Springer
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Цена: 19564.00 р.
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Описание: Heat Shock Proteins and maternal contribution to oogenesis and early embryogenesis.- The unmysterious roles of HSP90: Ovarian biology and autoantibodies.- The role of heat shock factors in mammalian spermatogenesis.- Heat shock protein A2 (HSPA2): Regulatory roles in germ cell development and sperm function.- The potential functions of small heat shock proteins in the uterine musculature during pregnancy.- The role of HSP70 in the regulation of autophagy in gametogenesis, pregnancy and parturition.- Roles of Grp78 in female mammalian reproduction.

MicroRNA in Development and in the Progression of Cancer

Автор: Shree Ram Singh; Pranela Rameshwar
Название: MicroRNA in Development and in the Progression of Cancer
ISBN: 1493944916 ISBN-13(EAN): 9781493944910
Издательство: Springer
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Цена: 19589.00 р.
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Описание: Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease.Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy.

Cancer Chemotherapy and Selective Drug Development

Автор: K.R. Harrap; W. Davis; A.H. Calvert
Название: Cancer Chemotherapy and Selective Drug Development
ISBN: 1461338395 ISBN-13(EAN): 9781461338390
Издательство: Springer
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Цена: 30606.00 р.
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Описание: Proceedings of the 10th Anniversary Meeting of the Coordinating Committee for Human Tumour Investigations, Brighton, England (24-28 October 1983)

New Approaches in Cancer Pharmacology: Drug Design and Development

Автор: Paul Workman
Название: New Approaches in Cancer Pharmacology: Drug Design and Development
ISBN: 3642790909 ISBN-13(EAN): 9783642790904
Издательство: Springer
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Цена: 18167.00 р.
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New Approaches in Cancer Pharmacology: Drug Design and Development

Автор: Paul Workman
Название: New Approaches in Cancer Pharmacology: Drug Design and Development
ISBN: 3642778763 ISBN-13(EAN): 9783642778766
Издательство: Springer
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Цена: 12157.00 р.
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Genes, Development and Cancer

Автор: Howard D. Lipshitz
Название: Genes, Development and Cancer
ISBN: 1461347467 ISBN-13(EAN): 9781461347460
Издательство: Springer
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Цена: 18167.00 р.
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Описание: Lewis` research papers are published within one volume- Papers are organized into sections that reflect the focus of the research- Commentaries by Howard Lipshitz highlight key methods and results by explaining the science so it is accessible to upper-level undergraduates, graduate students, and professional researchers

DNA Methylation: Development, Genetic Disease and Cancer

Автор: Walter Doerfler; Petra B?hm
Название: DNA Methylation: Development, Genetic Disease and Cancer
ISBN: 3642068308 ISBN-13(EAN): 9783642068300
Издательство: Springer
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Цена: 26120.00 р.
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Описание: It has become apparent that the genomes of many organisms are characterized by unique patterns of DNA methylation which can differ from genome segment to genome segment and cell type to cell type.


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