Kinase Signaling Networks, Aik-Choon Tan; Paul H. Huang

Автор: Peter K. Vogt; Stephen I. Reed
Название: Cyclin Dependent Kinase (CDK) Inhibitors
ISBN: 3642719430 ISBN-13(EAN): 9783642719431
Издательство: Springer
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Описание: More than 10 years ago, the discovery of cyclin-dependent ki- nases (Cdks) ushered in a new era in the understanding of cell proliferation and its control.

Автор: Mario D. Cordero; Benoit Viollet
Название: AMP-activated Protein Kinase
ISBN: 3319435876 ISBN-13(EAN): 9783319435879
Издательство: Springer
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Описание: AMPK has emerged as an important integrator of signals that control energy balance through the regulation of multiple biochemical pathways in eukaryotes. This book focuses on the implications of AMPK as a master metabolic regulator in diseases, including new methods and animal models. The contributions are written by leading experts in the field and give an extensive overview of the current knowledge of AMPK biology and the role of AMPK in health and disease. 

Автор: Alastair D. Reith
Название: Protein Kinase Protocols
ISBN: 1617371416 ISBN-13(EAN): 9781617371417
Издательство: Springer
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Автор: Hicham Zegzouti; Said A. Goueli
Название: Kinase Screening and Profiling
ISBN: 1493949233 ISBN-13(EAN): 9781493949236
Издательство: Springer
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Описание:

1. HTRF Kinase Assay Development and Methods in Inhibitor Characterization
Yong Jia, Mari Manuia, and Jose Juarez

2. Application of Eukaryotic Elongation Factor-2 Kinase (eEF-2K) for Cancer Therapy: Expression, Purification, and High-Throughput Inhibitor Screening
Clint D. J. Tavares, Ashwini K. Devkota, Kevin N. Dalby, and Eun Jeong Cho

3. Recombinant Kinase Production and Fragment Screening by NMR Spectroscopy
Byeonggu Han and Hee-Chul Ahn

4. Bioluminescence Methods for Assaying Kinases in Quantitative High-Throughput Screening (qHTS) Format Applied to Yes1 Tyrosine Kinase, Glucokinase and PI5P4Kα Lipid Kinase
Mindy I. Davis, Douglas S. Auld, and James Inglese

5. Using Bioluminescent Kinase Profiling Strips to Identify Kinase Inhibitor Selectivity and Promiscuity
Hicham Zegzouti, Jacquelyn Hennek, and Said A. Goueli

6. Measuring Activity of Phosphoinositide Lipid Kinases Using a Bioluminescent ADP-Detecting Assay
Andrew W. Tai and Jolanta Vidugiriene

7. A High-Throughput Radiometric Kinase Assay
Krisna C. Duong-Ly and Jeffrey R. Peterson

8. A High Content Assay to Screen for Modulators of EGFR Function
Christophe Antczak and Hakim Djaballah
9. Monitoring Protein Kinase Expression and Phosphorylation in Cell Lysates with Antibody Microarrays
Hong Zhang, Xiaoqing Shi, and Steven Pelech

10. From Enzyme to Whole Blood: Sequential Screening Procedure for Identification and Evaluation of p38 MAPK Inhibitors
Silke M. Bauer, Jakub M. Kubiak, Ulrich Rothbauer, and Stefan Laufer

11. Genetically Encoded Fluorescent Indicators to Visualize Protein Phosphorylation in Living Cells
Moritoshi Sato and Yoshio Umezawa

12. Characterization of an Engineered Src Kinase to Study Src Signaling and Biology
Leanna R. Gentry, Andrei V. Karginov, Klaus M. Hahn, and Channing J. Der

13. Screening One-Bead-One-Compound Peptide Libraries for Optimal Kinase Substrates
Thi B. Trinh and Dehua Pei

14. Determination of the Substrate Specificity of Protein Kinases with Peptide Micro- and Macroarrays
Shenshen Lai, Dirk F.H. Winkler, Hong Zhang, and Steven Pelech

15. Rapid Identification of Protein Kinase Phosphorylation Site Motifs Using Combinatorial Peptide Libraries
Chad J. Miller and Benjamin E. Turk

Автор: Khalil Ahmed; Olaf-Georg Issinger; Ryszard Szyszka
Название: Protein Kinase CK2 Cellular Function in Normal and Disease States
ISBN: 3319145436 ISBN-13(EAN): 9783319145433
Издательство: Springer
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Цена: 22359.00 р.
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Описание: Protein kinase CK2 (formerly casein kinase II or 2) is known to play a critical role in the control of cell growth and cell death and is thus intimately involved in the development of cancer. More specifically, CK2 has been found to be elevated in all cancers examined. While CK2 levels are known to be high in proliferating normal cells, CK2 has also been found to be a potent suppressor of apoptosis and is a link to the cancer cell phenotype, which is characterized by deregulation of both cell proliferation and cell death. Indeed, it would appear that CK2 impacts many of the hallmarks of cancer and it has now gained considerable attention as a potential target for cancer therapy. Protein Kinase CK2 and Cellular Function in Normal and Disease States increases knowledge of the role of CK2 in the development of cellular dysfunction and emphasizes that this protein may serve as a target of drug development for improved cancer therapy. In addition, it is a handy tool that provides cancer researchers, graduate students, and all scientists involved in CK2 research with one main source for the latest advances in CK2 research.

Автор: H. Lang
Название: Creatine Kinase Isoenzymes
ISBN: 3540107142 ISBN-13(EAN): 9783540107149
Издательство: Springer
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Описание: No one has counted the enzymes in the human organism, and probably their profuse number can only be estimated from the restrictions the finite mass of genetic material imposes.

Автор: Alexandra C. Newton
Название: Protein Kinase C Protocols
ISBN: 1617373354 ISBN-13(EAN): 9781617373350
Издательство: Springer
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Цена: 23058.00 р.
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Описание: Since the discovery that protein kinase C (PKC) transduces the ab- dance of signals that result in phospholipid hydrolysis, this enzyme has been at the forefront of research in signal transduction. The book ends with a presentation of genetic approaches to study PKC (Part X) and a discussion of approaches used to study PKC in disease (Part XI).