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The Molecular Biology of Paget`s Disease, Paul T. Sharpe


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Автор: Paul T. Sharpe
Название:  The Molecular Biology of Paget`s Disease
ISBN: 9783662225073
Издательство: Springer
Классификация:

ISBN-10: 3662225077
Обложка/Формат: Paperback
Страницы: 206
Вес: 0.39 кг.
Дата издания: 17.04.2014
Серия: Medical Intelligence Unit
Язык: English
Размер: 254 x 178 x 12
Основная тема: Biomedicine
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: The osteoclasts in Pagets disease are abnormal both in num- ber and size and show nuclear inclusions as well as cytoplasmic inclusions that suggest a viral etiology for Pagets disease. Use of in vitro model systems for examining osteoclast physiology in Pagets disease has shown that these cells have an increased rate of formation, express high levels of IL-6, IL-6 receptor, and NF-IL-6, as well as most recently, the c-FOS protooncogene. 31 The precur- sors for these pagetic osteoclasts have several abnormalities includ- ing hyperresponsivity to 1,25-dihydroxyvitamin D, presence of 3 measles virus nucleocapsid transcripts, and hyperresponsivity to the marrow microenvironment. In addition, the marrow microenviron- ment is also abnormal in Pagets disease. These data suggest that the initial pathologic event that occurs in Pagets disease affects the osteoclast precursor, as well as the mature osteoclast. The per- sistence of Pagets disease as a highly localized lesion(s) in patients following diagnosis may be due to the abnormalities in the mar- row microenvironment that induce abnormal circulating osteoclast precursors to home to the sites of previous disease and induce increased osteoclast formation in these areas. In areas of normal bone, the normal marrow microenvironment does not induce en- hanced osteoclast formation, but allows these cells to differentiate toward the monocyte macrophage lineage in the form of mature monocytes.


The Molecular Biology of Autoimmune Disease

Автор: Andrew G. Demaine; J.-Paul Banga; Alan M. McGregor
Название: The Molecular Biology of Autoimmune Disease
ISBN: 3642751350 ISBN-13(EAN): 9783642751356
Издательство: Springer
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Цена: 18167.00 р.
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Описание: Proceedings of the NATO Advanced Research Workshop on Molecular Biology and Autoimmune Disease held in Athens, Greece, from April 16-20, 1989

Cellular Cardiomyoplasty: Methods and Protocols (Methods in Molecular Biology)

Автор: Race L. Kao (Editor)
Название: Cellular Cardiomyoplasty: Methods and Protocols (Methods in Molecular Biology)
ISBN: 1627035109 ISBN-13(EAN): 9781627035101
Издательство: Springer
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Цена: 16769.00 р.
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Описание: In Cellular Cardiomyoplasty: Methods and Protocols, expert researchers in the field detail many of the methods which are now commonly used to study cellular cardiomyoplasty, only adult stem cells or adult progenitor cells are included.

Progress in Molecular and Subcellular Biology

Автор: S. Bram
Название: Progress in Molecular and Subcellular Biology
ISBN: 364266251X ISBN-13(EAN): 9783642662515
Издательство: Springer
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Цена: 18167.00 р.
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Progress in Molecular and Subcellular Biology 3

Автор: Robert E. Rhoads
Название: Progress in Molecular and Subcellular Biology 3
ISBN: 3642655807 ISBN-13(EAN): 9783642655807
Издательство: Springer
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Цена: 18167.00 р.
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Molecular mechanisms and physiology of disease

Автор: Maulik
Название: Molecular mechanisms and physiology of disease
ISBN: 1493907050 ISBN-13(EAN): 9781493907052
Издательство: Springer
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Цена: 32142.00 р.
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Описание: In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.

Molecular Biology and Evolution of Blood Group and MHC Antigens in Primates

Автор: Antoine Blancher; Jan Klein; Wladyslaw W. Socha
Название: Molecular Biology and Evolution of Blood Group and MHC Antigens in Primates
ISBN: 3642638430 ISBN-13(EAN): 9783642638435
Издательство: Springer
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Цена: 16979.00 р.
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Описание: Zoologists have categorized primates into a single order, and no one doubts today that they share a common ancestry. Humans and Old and New World non- human primate species, from the lemurs of Madagascar to the African anthro- poid apes, represent diverging branches of an evolutionary common trunk.

Candida albicans: Cellular and Molecular Biology

Автор: Rajendra Prasad
Название: Candida albicans: Cellular and Molecular Biology
ISBN: 3319504088 ISBN-13(EAN): 9783319504087
Издательство: Springer
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Цена: 27950.00 р.
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Описание: 1. Fungal infectionsJohn E Edwards1 and Priya Uppuluri2UCLA David Geffen School of Medicine, USA. 1E-mail: jedwards@labiomed.org, 2E-mail: puppuluri@labiomed.org2. Fungal infections- The South-Asian perspectiveArunaloke ChakrabartiDivision of Mycology, Postgraduate Institute of Medical Education & Research, Chandigarh, India. E-mail: arunaloke@gmail.com3. Regulatory pathways during C. albicans infectionsAaron P. MitchellMellon Institute, Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, USA. E-mail: apm1@andrew.cmu.edu4. Virulence mechanisms and regulationChristophe D'EnfertFungal Biology and Pathogenicity Unit - INRA USC2019, Department of Mycology, Institut Pasteur, Paris, France. E-mail: christophe.denfert@pasteur.fr
5. Signalling mechanisms in pathogenesis and virulence of C. albicans 6. Biofilm development by C. albicansDavid AndesDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison WI, USA. E-mail: dra@medicine.wisc.edu7. Biofilm development and resistance mechanisms by C. albicansPatrick Van Dijck1 and Mary-Ann Jabra Rizk21 VIB Department of Molecular Microbiology, KU Leuven, Kasteelpark, Arenberg, Leuven, Belgium. 2 University of Maryland School of Dentistry, Maryland, USA. 1E-mail: Patrick.VanDijck@mmbio.vib-kuleuven.be, 2E-mail: MRizk@umaryland.edu8. Biofilm of C. albicans: development and regulationAshraf S. Ibrahim1 and Priya Uppuluri29. Host immune responses during infectionsGordon BrownThe Institute of Medical Sciences, University of Aberdeen, Scotland. E-mail: gordon.brown@abdn.ac.uk10. Mechanism of drug resistance Dominique SanglardInstitute of Microbiology, University Hospital Lausanne and University Hospital Center, Lausanne, Switzerland. E-mail: Dominique.Sanglard@chuv.ch11. Structure- function analyses of Multi-drug transportersRichard D. Cannon Department of Oral Sciences, University of Otago, Dunedin, New Zealand. E-mail: richard.cannon@otago.ac.nz12. All about MFS multi-drug transporter of Candida albicansRajendra Prasad1, Peer Abdul Haseeb Shah2 and Archana Redhu21Amity Institute of Integrative Sciences and Health and Amity Institute of Biotechnology, Amity University, Haryana, India. 2Membrane biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India. 1E-mail: rp47jnu@gmail.com, rprasad@ggn.amity.edu13. Inhibitors/Modulators of MDR transporters Attilio Di PietroInstitute for the Biology and Chemistry of Protein, Lyon, France. E-mail: a.dipietro@ibcp.fr14. Inhibitors/Modulators of MDR proteins/transportersBrian MonkDepartment of Oral Sciences, University of Otago, Dunedin, New Zealand. E-mail: brian.monk@otago.ac.nz15. Anti-fungals
David PerlinPublic Health Research Institute Center, New Jersey Medical School - Rutgers, The State University of New Jersey, New Jersey, USA. E-mail: perlinds@umdnj.edu16. Anti-microbial peptidesJoachim Ernst and Marc SwidergallInstitut fьr Mikrobiologie, Molekulare M

Molecular Biology of Long Non-coding RNAs

Автор: Ahmad M. Khalil; Jeff Coller
Название: Molecular Biology of Long Non-coding RNAs
ISBN: 1493945289 ISBN-13(EAN): 9781493945283
Издательство: Springer
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Цена: 19589.00 р.
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Описание: This book examines key issues in lncRNA biology, including critical studies that have led to the discovery and annotation of lncRNAs in numerous species and the molecular mechanisms for a few lncRNA that have begun to emerge.


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