Organellar Proton-ATPases, Nathan Nelson

Автор: Masamitsu Futai
Название: Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology
ISBN: 3527306897 ISBN-13(EAN): 9783527306893
Издательство: Wiley
Цена: 19008.00 р.
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Описание: As the first comprehensive overview of this important class of enzymes, this two-volume handbook summarizes recent knowledge about the molecular mechanism of ATPases, relating this information to the physiology and pathopyhsiology of ion transport, mitochondrial function, vesicle transport and lysosomal acidification. All important P-type, F-type and V-type ATPases are treated systematically, compmented by a special section on the cell biology and physiology of acidic compartments, and backed by an extensive bibliography and index. This premier reference source for physiologists, molecular biologists, biophysicists and clinical researchers contains contributions by more than 20 of the world's foremost ATPase research groups.

Автор: Peter K??
Название: Thin-Film Catalysts for Proton Exchange Membrane Water Electrolyzers and Unitized Regenerative Fuel Cells
ISBN: 3030208583 ISBN-13(EAN): 9783030208585
Издательство: Springer
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Описание: This work revolves around the hydrogen economy and energy-storage electrochemical systems. More specifically, it investigates the possibility of using magnetron sputtering for deposition of efficient thin-film anode catalysts with low noble metal content for proton exchange membrane water electrolyzers (PEM-WEs) and unitized regenerative fuel cells (PEM-URFCs). The motivation for this research derives from the urgent need to minimize the price of such electrochemical devices should they enter the mass production.Numerous experiments were carried out, correlating the actual in-cell performance with the varying position of thin-film catalyst within the membrane electrode assembly, with the composition of high-surface support sublayer and with the chemical structure of the catalyst itself. The wide arsenal of analytical methods ranging from electrochemical impedance spectroscopy through electrochemical atomic force microscopy to photoelectron spectroscopy allowed the description of the complex phenomena behind different obtained efficiencies.Systematic optimizations led to the design of a novel PEM-WE anode thin-film iridium catalyst which performs similarly to the standard counterparts despite using just a fraction of their noble metal content. Moreover, the layer-by-layer approach resulted in the design of a Ir/TiC/Pt bi-functional anode for PEM-URFC which is able to operate in both the fuel cell and electrolyzer regime and thus helps to cut the cost of the whole conversion system even further.

Автор: Galluzzi, Lorenzo
Название: Inter-Organellar Ca2+ Signaling In Health And Disease - Part A,362
ISBN: 0128240342 ISBN-13(EAN): 9780128240342
Издательство: Elsevier Science
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Описание:

Inter-Organellar Ca2+ Signaling in Health and Disease - Part A, Volume 362, the latest release in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Автор: Galluzzi, Lorenzo
Название: Inter-Organellar Ca2+ Signaling In Health And Disease - Part B,363
ISBN: 0128240369 ISBN-13(EAN): 9780128240366
Издательство: Elsevier Science
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Описание:

International Review of Cell and Molecular Biology reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists.

Автор: Nelson Ron
Название: Protons Versus Prostate Cancer: Exposed: Learn What Proton Beam Therapy for Prostate Cancer Is Really Like from the Patient`s Point of View in Complet
ISBN: 0985082305 ISBN-13(EAN): 9780985082307
Издательство: Неизвестно
Цена: 2750.00 р.
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Автор: Sajal Chakraborti; Naranjan S Dhalla
Название: Regulation of Ca2+-ATPases,V-ATPases and F-ATPases
ISBN: 3319796771 ISBN-13(EAN): 9783319796772
Издательство: Springer
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Описание: The biological membranes of cellular organization enfold an important group of membrane proteins called the ATPases, which are not only versatile in maintaining chemical gradient and electrical potential across the membrane but also bring metabolites necessary for cell metabolism and drive out toxins, waste products and solutes that otherwise can curb cell functions. ATPases are distributed virtually in all live forms starting from unicellular to multicellular and also in viruses. There are different types of ATPases, which differ in function and structure and in the type of ions they transport. The three main types of the ion pump ATPase family are: (i) P-type ATPases that transport different ions across membranes and Ca2+ATPases belongs to this catagory (ii) F-type ATPase in mitochondria, chloroplasts and bacterial plasma membranes produce ATP using the proton gradient; and (iii) V-type ATPase catalyzes ATP hydrolysis to transport solutes and maintains acidic pH in organelles like lysosomes. Genetic defects in either of the ATPases cause several diseases and a number of researches have demonstrated the involvement of the members of ATPases in the cell pathology and diseases, thereby penetrating exciting new areas of our understanding. In this book, the authors summarize recent knowledge about the molecular mechanisms associated with Ca2+-ATPase, V-ATPase and F-ATPase in intracellular and extracellular Ca2+ transport, mitochondrial ATP synthase, vesicular H+ transport, and lysosomal pH regulation. This book thereby bridges the gap between fundamental research and biomedical and pharmaceutical applications. The book provides an informative resource to improve ATPase research and modern therapeutic approaches toward different life threatening diseases that are associated with dysregulation of the ATPases.

Автор: Liselotte Plesner; Terence L. Kirley; Aileen F. Kn
Название: Ecto-ATPases
ISBN: 1461377293 ISBN-13(EAN): 9781461377290
Издательство: Springer
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Описание: Proceedings of the First International Workshop held in Mar de Plata, Argentina, August 26-30, 1996

Автор: Maike Bublitz
Название: P-Type ATPases
ISBN: 1493979957 ISBN-13(EAN): 9781493979950
Издательство: Springer
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Цена: 21661.00 р.
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Описание:

1. An Introduction to P-type ATPase research

Poul Nissen

Part I: Protein Production, Isolation, Purification, and Stabilization

2. Purification of Na, K-ATPase from Pig Kidney

Natalya U. Fedosova

3. Preparation of Ca²⁺-ATPase1a Enzyme from Rabbit Sarcoplasmic Reticulum

Jesper V. M ller and Claus Olesen

4. Isolation of H⁺/K⁺-ATPase-enriched Membrane Fraction from Pig Stomachs

Kazuhiro Abe and Claus Olesen

5. Overproduction of PiB-type ATPases

Xiangyu Liu, Oleg Sitsel, Kaituo Wang, and Pontus Gourdon

6. Coordinated Overexpression in Yeast of a P4-ATPase and its Associated Cdc50 Subunit: The Case of the Drs2p/Cdc50p Lipid Flippase Complex

Hassina Azouaoui, Cйdric Montigny, Aurore Jacquot, Raphaлlle Barry, Philippe Champeil, and Guillaume Lenoir

7. The Plasma Membrane Ca²⁺-ATPase: Purification by Calmodulin Affinity Chromatography, and Reconstitution of the Purified Protein

Verena Niggli and Ernesto Carafoli

8. Expression of Na, K-ATPase and H, K-ATPase Isoforms With The Baculovirus Expression System

Jan B. Koenderink and Herman G.P. Swarts

9. Time-dependent Protein Thermostability Assay

Ilse Vandecaetsbeek and Peter Vangheluwe

Part II: Activity Assays

10. Colorimetric Assays of Na, K-ATPase

Kathleen J. Sweadner

11. ATPase Activity Measurements by an Enzyme-Coupled Spectrophotometric Assay Pankaj Sehgal, Claus Olesen, and Jesper V. M ller

12. Antimony-Phosphomolybdate ATPase Assay

Gianluca Bartolommei and Francesco Tadini-Buoninsegni

13. ATPase Activity Measurements using radiolabeled ATP

Herman G.P. Swarts and Jan B. Koenderink

14. Assaying P-type ATPases Reconstituted in Liposomes

Hans-Jьrgen Apell and Bojana Damnjanovic

15. Coupling ratio for Ca²⁺ Transport by Calcium Oxalate Precipitation

Pankaj Sehgal, Claus Olesen, and Jesper V. M ller

16. Calcium Uptake in Crude Tissue Preparation

Philip A. Bidwell and Evangelia G. Kranias

17. Measuring H⁺ Pumping and Membrane Potential Formation in Sealed Membrane Vesicle Systems

Автор: Lars Olbe
Название: Proton Pump Inhibitors
ISBN: 3034897774 ISBN-13(EAN): 9783034897778
Издательство: Springer
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Цена: 25155.00 р.
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Описание: Inhibition of the proton pump in the parietal cells has been established as the main therapeutic principle in the treatment of acid-related diseases, such as peptic ulcer and gastro-oesophageal reflux.

Название: P-type atpases
ISBN: 1493931784 ISBN-13(EAN): 9781493931781
Издательство: Springer
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Цена: 27950.00 р.
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Описание:

1. An Introduction to P-type ATPase research

Poul Nissen

Part I: Protein Production, Isolation, Purification, and Stabilization

2. Purification of Na, K-ATPase from Pig Kidney

Natalya U. Fedosova

3. Preparation of Ca²⁺-ATPase1a Enzyme from Rabbit Sarcoplasmic Reticulum

Jesper V. M ller and Claus Olesen

4. Isolation of H⁺/K⁺-ATPase-enriched Membrane Fraction from Pig Stomachs

Kazuhiro Abe and Claus Olesen

5. Overproduction of PiB-type ATPases

Xiangyu Liu, Oleg Sitsel, Kaituo Wang, and Pontus Gourdon

6. Coordinated Overexpression in Yeast of a P4-ATPase and its Associated Cdc50 Subunit: The Case of the Drs2p/Cdc50p Lipid Flippase Complex

Hassina Azouaoui, Cйdric Montigny, Aurore Jacquot, Raphaлlle Barry, Philippe Champeil, and Guillaume Lenoir

7. The Plasma Membrane Ca²⁺-ATPase: Purification by Calmodulin Affinity Chromatography, and Reconstitution of the Purified Protein

Verena Niggli and Ernesto Carafoli

8. Expression of Na, K-ATPase and H, K-ATPase Isoforms With The Baculovirus Expression System

Jan B. Koenderink and Herman G.P. Swarts

9. Time-dependent Protein Thermostability Assay

Ilse Vandecaetsbeek and Peter Vangheluwe

Part II: Activity Assays

10. Colorimetric Assays of Na, K-ATPase

Kathleen J. Sweadner

11. ATPase Activity Measurements by an Enzyme-Coupled Spectrophotometric Assay Pankaj Sehgal, Claus Olesen, and Jesper V. M ller

12. Antimony-Phosphomolybdate ATPase Assay

Gianluca Bartolommei and Francesco Tadini-Buoninsegni

13. ATPase Activity Measurements using radiolabeled ATP

Herman G.P. Swarts and Jan B. Koenderink

14. Assaying P-type ATPases Reconstituted in Liposomes

Hans-Jьrgen Apell and Bojana Damnjanovic

15. Coupling ratio for Ca²⁺ Transport by Calcium Oxalate Precipitation

Pankaj Sehgal, Claus Olesen, and Jesper V. M ller

16. Calcium Uptake in Crude Tissue Preparation

Philip A. Bidwell and Evangelia G. Kranias

17. Measuring H⁺ Pumping and Membrane Potential Formation in Sealed Membrane Vesicle Systems

Автор: Santosh Yajnik
Название: Proton Beam Therapy
ISBN: 1489986715 ISBN-13(EAN): 9781489986719
Издательство: Springer
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Цена: 19564.00 р.
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Описание: Proton beam therapy is an emerging technology with promise of revolutionizing the treatment of cancer. While nearly half of all patients diagnosed with cancer in the US receive radiation therapy, the majority is delivered via electron accelerators, where photons are used to irradiate cancerous tissue. Because of the physical properties of photon beams, photons may deposit energy along their entire path length through the body. On the other hand, a proton beam directed at a tumor travels in a straight trajectory towards its target, gives off most of its energy at a defined depth called the Bragg peak, and then stops. While photons often deposit more energy within the healthy tissues of the body than within the cancer itself, protons can deposit most of their cancer-killing energy within the area of the tumor. As a result, in the properly selected patients, proton beam therapy has the ability to improve cure rates by increasing the dose delivered to the tumor and simultaneously reduce side-effects by decreasing the dose to surrounding tissue. The benefits of proton beam therapy in delivering a lethal hit to the target while sparing surrounding normal tissues from radiation are becoming applicable to an increasing number of patients and a growing list of conditions. In this book, the author will guide the reader through existing evidence supporting proton beam therapy for pediatric cancer, prostate cancer, lung cancer, brain tumors, spinal tumors, and several other conditions. The book will discuss which conditions are suitable for treatment with proton beam therapy, how the treatment is delivered, and the current data supporting its use.

Автор: Ulascan Sarica
Название: Measurements of Higgs Boson Properties in Proton-Proton Collisions at ?s =7, 8 and 13 TeV at the CERN Large Hadron Collider
ISBN: 3030254739 ISBN-13(EAN): 9783030254735
Издательство: Springer
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Описание: This thesis documents the measurement of lifetime, width, mass, and couplings to two electroweak bosons of the recently-discovered Higgs boson using data from the CMS experiment at the Large Hadron Collider. Both on-shell (at the mass of around 125 GeV) and off-shell (above 200 GeV) Higgs boson production is studied and an excess of off-shell production with significance above two standard deviations is observed for the first time. The latter is a qualitative new way to study the Higgs field, responsible for generation of mass of all the known elementary particles. In addition, phenomenological tools have been developed with the Monte Carlo event generator and matrix element techniques for an optional analysis of LHC data. Optimization of the CMS data with careful alignment of the silicon tracker is also presented.