Описание: In multicellular organisms, communication between cells involves secretion of proteins that bind to receptors on neighboring cells. While this has been well documented, another mode of intercellular communication has recently become the subject of increasing interest: the release of exosomes. In cancer, tumor exosomes are involved in various aspects of pathogenesis, including proliferation, immunosuppression, and metastasis. Given the ability of exosomes to export unneeded endogenous molecules from cells, these structures hold great potential as anticancer therapeutic agents. They are also being studied as prognostic markers for cancer.
Автор: Zhang Название: RNAi and microRNA-Mediated Gene Regulation in Stem Cells ISBN: 1607617684 ISBN-13(EAN): 9781607617686 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This cutting-edge text will be a valuable resource for scientists and aspiring graduate students interested in the intersection of RNAi, miRNA, and stem cell molecular biology and exciting areas of research such as regenerative medicine and cancer.
Автор: Swathi Arur Название: Signaling-Mediated Control of Cell Division ISBN: 3319448196 ISBN-13(EAN): 9783319448190 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: 1. Role of chromatin modifications in germline stem cell differentiationPooja Flora, Maitreyi Upadhyay, Alicia McCarthy, Prashanth Rangan Prashanth Rangan prangan@albany.edu 2. Regulation of the balance between proliferation and differentiation in germline stem cells.Ramya Singh and David HansenDavid Donald Hansen dhansen@ucalgary.ca 3. Control of germ line stem cell lineages by diet and physiologyKaitlyn Laws and Daniela Drummond-BarbosaDaniela Barbosa dbarbosa@jhu.edu 4. Signal-mediated regulation of meiotic prophase I during oogenesisKenneth Trimmer and Swathi ArurSwathi Arur sarur@mdanderson.org 5. Prophase I: preparing chromosomes for segregation in the developing oocyteRachel Harney, Benjamin Alleva, Sarit SmolikovSarit Smolikov saritsmol@gmail.com 6. Translational control of germ cell decisionsKumari Pushpa, Amaresh Chaturbedi, Ganga Anil Kumar and Kuppuswamy SubramaniamK Subramaniam subbu@iitm.ac.in 7. Prostagladin signaling from oocyte to spermHieu Dinh Hoang and Michael MillerMichael Miller mamiller@uab.edu 8. Cell fate maintenance and reprogramming during the oocyte-to-embryotransition'Christina Fassnacht and Rafal CioskRafal Ciosk rafal.ciosk@fmi.ch 9. Maternal to zygotic transitions across evolutionRueyling Lin rueyling.lin@utsouthwestern.edu 10 Cell cycle regulation in oocytesKubiak JZ and Borsuk EUniversity of Rennes, FranceJacek Kubiak. jacek.kubiak@univ-rennes1.fr 11 Oocyte activation and fertilization: crucial sperm and oocyte factorsMarc Yeste, Celine Jones, Siti N. Amdani, Kevin CowardUniversity of OxfordMarc Yeste. marc.yeste@obs-gyn.ox.ac.uk
Автор: JOSE ISAGANI B. JANAIRO Название: Peptide-Mediated Biomineralization ISBN: 9811008574 ISBN-13(EAN): 9789811008573 Издательство: Springer Рейтинг: Цена: 7836.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book describes recent advances in peptide-mediated biomineralization and how this method was able to create improved catalysts through minor tweaks in the system.
Автор: Devendra K. Choudhary; Ajit Varma Название: Microbial-mediated Induced Systemic Resistance in Plants ISBN: 9811003874 ISBN-13(EAN): 9789811003875 Издательство: Springer Рейтинг: Цена: 19591.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: 1. Changes in phytochemicals in response to rhizospheric microorganisms infection Mehrnaz Hatami, Mansour Ghorbanpour 2. Bacillus-mediated induced systemic resistance (ISR) against Fusarium corm rot Shanu Magotra, Deepika Trakroo, Sneha Ganjoo and Jyoti Vakhlu 3. Plant growth-promoting rhizobacteria: key mechanisms of action Mбrcia do Vale Barreto Figueiredo, Aurenнvia Bonifacio, Artenisa Cerqueira Rodrigues, Fabio Fernando de Araujo 4. Priming of plant defense and plant growth in disease challenged crops using microbial consortia Murugan Kumar, Nanjappan Karthikeyan, and Radha Prasanna 5. Seed priming mediated induced disease resistance in arid zone plants Rakesh Pathak, Praveen Gehlot and S.K. Singh 6. Trichoderma secondary metabolites: their biochemistry and possible role in disease management Anita Surendra Patil, Surendra Rajaram Patil and Hariprasad Madhukarrao Paikrao 7. Induced systemic resistance in rice Kalaivani K. Nadarajah 8. Plant growth promoting rhizobacteria mediated acquired systemic resistance in plants against pests and diseases S.K. Singh, Rakesh Pathak and Vipin Chaudhary 9. Acyl homoserine lactone producing rhizobacteria-elicit systemic resistance in plants Ganga Viswanath, Jegan Sekar, and V.R. Prabhavathy 10. Biological Control of chickpea Fusarium wilt using rhizobacteria "PGPR" Souad Zaim, Lakhdar Belabid, Bassam Bayaa 11. AM fungal effect on the growth of selective dicot and monocot plants B. Sadhana*, P. K. Monica and S. Siva Sankari 12. Trichoderma spp.: Efficient Inducers of Systemic Resistance in Plants Kartikay Bisen, Chetan Keswani, J. S. Patel, B. K. Sarma, H. B. Singh 13. Induced systemic resistance by rhizospehric microbes Manoj Kumar, Priyanku Teotia, Ajit Varma, Narendra Tuteja, and Vivek Kumar 14. Combinations of plant growth-promoting rhizobacteria (PGPR) for initiation of systemic resistance against tree diseases Vivek Kumar, Ajit Varma Narendra Tuteja and Manoj Kumar 15. Plant growth promoting microbial-mediated induced systemic resistance in plants: induction, mechanism and expression Shekhar Jain, Ajit Varma, Narendra Tuteja, D.K. Choudhary
Автор: T. Zollner; Harald Renz; Khusru Asadullah Название: Animal Models of T Cell-Mediated Skin Diseases ISBN: 3642422055 ISBN-13(EAN): 9783642422058 Издательство: Springer Рейтинг: Цена: 22201.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character.
Описание: This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative fluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells.
Автор: Wolf H. Fridman Название: Cell-Mediated Effects of Immunoglobulins ISBN: 0412118211 ISBN-13(EAN): 9780412118210 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Benjamin Bonavida; Salem Chouaib Название: Resistance of Cancer Cells to CTL-Mediated Immunotherapy ISBN: 3319178067 ISBN-13(EAN): 9783319178066 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, tumor cells develop anti-apoptotic mechanisms and thereby, resist CTL-induced apoptosis. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. Examples of such agents discussed in the volume include are HDAC inhibitors, proteasome inhibitors, Bcl-2 family inhibitors, PARP, antibodies, and more.
Описание: All coordination between cells, organs, and organisms depends on successful biocommunicative processes.
Автор: Yaoliang Tang Название: Mesenchymal Stem Cell Derived Exosomes ISBN: 012800164X ISBN-13(EAN): 9780128001646 Издательство: Elsevier Science Рейтинг: Цена: 12462.00 р. Наличие на складе: Поставка под заказ.
Описание: Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool.
Автор: Baohong Zhang; Edmund J. Stellwag Название: RNAi and microRNA-Mediated Gene Regulation in Stem Cells ISBN: 149395749X ISBN-13(EAN): 9781493957491 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Recent stem cell research has revealed that miRNA and RNAi-mediated gene regulation is one of the vital determinates controlling the state of cell differentiation, with the small RNAs serving as key elements involved in regulatory network control of pluripotent cell fate determination. In RNAi and microRNA-Mediated Gene Regulation in Stem Cells: Methods, Protocols, and Applications, expert authors from laboratories across the globe contribute an accessible compendium of up-to-date, proven methods focused on the study of the titular topic. Divided into three sections, the book first gives a brief introduction to RNAi and miRNAs in stem cells, with a focus on the current status of research and future perspectives, then it continues with detailed methods and protocols for RNAi screening, transfection, and the knockdown of specific genes and pathways in several animal species, including humans and mice, concluding with a section on recently developed methods for identification of miRNAs, including a general protocol for preparation and analysis of miRNA libraries for deep sequencing, knock down of a specific gene using miRNA-based shRNA, and miRNA expression analysis using qRT-PCR. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes highlighting tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, RNAi and microRNA-Mediated Gene Regulation in Stem Cells: Methods, Protocols, and Applications serves as a valuable resource for scientists and aspiring graduate students interested in the intersection of RNAi, miRNA, and stem cell molecular biology and the exciting areas of medicine, including regenerative medicine, aging, cancer, and neurological disorders, that can be advanced through this expanding area of research.
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