This unique book deals with both inflammation and cancer in a single source of publication. They are seldom grouped together although it has been known that both diseases are closely associated, particularly in the gastrointestinal tract and liver. As the book touches on two such major areas of diseases in humans, it should be of interest to a wider audience of researchers and readers. It is noted that the book combines the effort of both basic scientists and clinicians from different countries with extensive experiences in molecular biology and clinical practice to unveil the most updated picture of the pathogenesis and therapeutic strategies in the treatment of inflammation and cancer in the digestive tract. In this regard, potential pathogenic modulators and also therapeutic options are widely discussed. These types of information would definitely broaden our knowledge in better understanding these diseases.
Описание: As our understanding of apoptotic pathway expands, we are coming to realize the great potential of utilizing this pathway to treat diseases such as cancer. The book attempts to review, summarize, and speculate on the apoptotic pathways, how are they regulated and how targeted therapies are being used to treat a wide variety of diseases. Special emphasis is placed on cancer since new treatments either being developed or currently in the clinical setting are showing great promise to increase survival rates for cancer patients. Chapters will address the biology behind regulating the apoptotic pathways and what goes wrong in disease states whereas other chapters will concentrate on new therapies targeting apoptotic pathways. The reader by the end of the book should have greater insight into the understanding and utilization of apoptotic pathways to fight diseases such as cancer.
Автор: George G. Chen; Paul B.S. Lai Название: Novel Apoptotic Regulators in Carcinogenesis ISBN: 9400794932 ISBN-13(EAN): 9789400794931 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Our recent understanding of the cellular and molecular defects and the regulation of the apoptotic signalling pathways has resulted in rationally designed anticancer strategies and the development of novel agents that regulates apoptosis. A comprehensive review of all apoptotic-related anticancer therapies is not the purpose of this book. However, in the volume of this book with 11 chapters, we have described a number of novel apoptotic regulators that have shown promising value and also great feasibility for cancer treatment. These novel agents either occur naturally or are chemically synthesized. While we are excited about the discovery and development of these novel apoptotic regulators as potential anticancer agents, a degree of caution should be always borne in mind when interpreting the success of preclinical pro-apoptotic candidates since potential problems inevitably lie ahead. These problems usually include target specificity, unanticipated toxicity, compound stability, formulation issues, pharmacokinetic and pharmacodynamic profiles. Nevertheless, we believe that this collection of 11 chapters by established leaders in the area of apoptosis will be of great interest to not only academics working in the field of cancer research and apoptosis but also pharmaceutical and pharmacological industries that . We are looking forward to the further development to push these potential agents toward clinical stage.
Автор: Shigekazu Nagata; Hiroyasu Nakano Название: Apoptotic and Non-apoptotic Cell Death ISBN: 3319239120 ISBN-13(EAN): 9783319239125 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume focuses on apoptotic and non-apoptotic programmed cell death, including necroptosis, pyroptosis, and ferroptosis, and presents recent findings in the field.
Автор: Champney W. Scott Название: New Antibiotic Targets ISBN: 1588299155 ISBN-13(EAN): 9781588299154 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Examines specific techniques which can be used to explore new drug targets and the effectiveness of new antibiotics. This volume features drug targets including peptide deformylase, ribosome formation, lipopolysaccharide and fatty acid biosynthesis and signal transduction pathways.
Автор: Gaginella Timothy S., Guglietta Antonio Название: Drug Development / Molecular Targets for GI Diseases ISBN: 0896035891 ISBN-13(EAN): 9780896035898 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The application of molecular techniques to gastroenterology continues to yield important advances in the development of drugs to treat gastrointestinal disorders.
Автор: R. Numerof; Charles A. Dinarello; Khusru Asadullah Название: Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases ISBN: 3642421822 ISBN-13(EAN): 9783642421822 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Cytokines and cytokine receptors remain an area of great interest for the development of targeted therapies for cutaneous inflammatory diseases. In addition to therapeutics that target cytokines directly, strategies that target cytokine signaling pathways are in development.
Автор: Gaspar Banfalvi Название: Apoptotic Chromatin Changes ISBN: 9401777241 ISBN-13(EAN): 9789401777247 Издательство: Springer Рейтинг: Цена: 33401.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Apoptosis, or cell suicide, is an integral part of the life cycle. This book shows the dynamic change of chromatin structures in a cell cycle-dependent manner.
Автор: Nicholas B. La Thangue; Lasantha R. Bandara Название: Targets for Cancer Chemotherapy ISBN: 1617372633 ISBN-13(EAN): 9781617372636 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
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