Novel Immune Potentiators and Delivery Technologies for Next Generation Vaccines, Manmohan Singh

Автор: Gregory Gregoriadis; Brenda McCormack; Anthony C.
Название: New Generation Vaccines
ISBN: 1461362814 ISBN-13(EAN): 9781461362814
Издательство: Springer
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Описание: Proceedings of a NATO ASI held at Cape Sounion Beach, Greece, June 24-July 5, 1992.

Автор: Yehuda Shoenfeld,Nancy Agmon–Levin
Название: Vaccines and Autoimmunity
ISBN: 1118663438 ISBN-13(EAN): 9781118663431
Издательство: Wiley
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Описание: In light of the discovery of Autoimmune Syndrome Induced by Adjuvants, or ASIA, Vaccines and Autoimmunity explores the role of adjuvants specifically aluminum in different vaccines and how they can induce diverse autoimmune clinical manifestations in genetically prone individuals.

Автор: Sara Cohen; Avigdor Shafferman
Название: Novel Strategies in the Design and Production of Vaccines
ISBN: 0306452111 ISBN-13(EAN): 9780306452116
Издательство: Springer
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Описание: Proceedings of the 39th OHOLO Conference held in Eilat, Israel, May 7-11, 1995.

Автор: Sara Cohen; Avigdor Shafferman
Название: Novel Strategies in the Design and Production of Vaccines
ISBN: 148991384X ISBN-13(EAN): 9781489913845
Издательство: Springer
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Описание: Proceedings of the 39th OHOLO Conference held in Eilat, Israel, May 7-11, 1995.

Автор: Alexander von Gabain; Christoph Klade
Название: Development of Novel Vaccines
ISBN: 3709117046 ISBN-13(EAN): 9783709117040
Издательство: Springer
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Описание: Covering the entire process of developing a vaccine-from early, basic research right up to the final product itself, and approaching the subject from a variety of perspectives, this volume will be required reading for researchers engaged in vaccine creation.

Автор: Edouard Kurstak; R.G. Marusyk; F.A. Murphy; M.H.V.
Название: New Vaccines and Chemotherapy
ISBN: 0306426595 ISBN-13(EAN): 9780306426599
Издательство: Springer
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Описание: Viral Vaccines Joseph L. These reports, plus a third on Vaccine Supply and Innovation (1985a), should be required reading for all those in both the public and the private sector who have a responsibility or interest in vaccines for the prevention of human disease.

Автор: Dushyant Varshney; Manmohan Singh
Название: Lyophilized Biologics and Vaccines
ISBN: 1493955683 ISBN-13(EAN): 9781493955688
Издательство: Springer
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Описание: This book provides a detailed account of the most recent developments, challenges and solutions to seamlessly advance and launch a lyophilized biologics or vaccine product, based on diverse modalities, ranging from antibodies (e.g., monoclonal, fused), complex biologics (e.g., antibody drug conjugate, PEGylated proteins), and vaccines (e.g., recombinant-protein based). The authors adeptly guide the reader through all crucial aspects, from biophysical and chemical stability considerations of proteins, analytical methods, advances in controlled ice nucleation and quality-by-design approaches, alternate drying technology, to latest regulatory, packaging and technology transfer considerations to develop a stable, safe and effective therapeutic protein, vaccine and biotechnology products. Lyophilized Biologics and Vaccines: Modality-Based Approaches is composed of four sections with a total of 17 chapters. It serves as a reference to all critical assessments and steps from early pre-formulation stages to product launch: * Provides recent understanding of heterogeneity of protein environment and selection of appropriate buffer for stabilization of lyophilized formulations * Details the latest developments in instrumental analysis and controlled ice nucleation technology * Explains in-depth lyophilized (or dehydrated) formulation strategies considering diverse modalities of biologics and vaccines, including plasmid DNA and lipid-based therapeutics * Details an exhaustive update on quality-by-design and process analytical technology approaches, illustrated superbly by case studies and FDA perspective * Provides the latest detailed account of alternate drying technologies including spray drying, bulk freeze-drying and crystallization, supported exceptionally by case studies * Provides a step-by-step guide through critical considerations during process scale-up, technology transfer, packaging and drug delivery device selection, for a successful lyophilization process validation, regulatory submission and product launch Chapters are written by one or more world-renowned leading authorities from academia, industry or regulatory agencies, whose expertise cover lyophilization of the diverse modalities of biopharmaceuticals. Their contributions are based on the exhaustive review of literature coupled with excellent hands-on experiences in laboratory or GMP setup, making this an exceptional guide to all stages of lyophilized or dehydrated product development.

Автор: Michael J.P. Lawman; Patricia D. Lawman
Название: Cancer Vaccines
ISBN: 1493951955 ISBN-13(EAN): 9781493951956
Издательство: Springer
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Описание:

Part I: Manipulation and Modification of Immune Cells: Dendritic Cells

1. Single Step Antigen Loading and Maturation of Dendritic Cells Through mRNA Electroporation of a Tumor-Associated Antigen and a TriMix of Costimulatory Molecules

Daphnй Benteyn, An M.T. Van Nuffel, Sofie Wilgenhof, and Aude Bonehill

2. Generation of Multiple Peptide Cocktail-Pulsed Dendritic Cells as a Cancer Vaccine

Hyun-Ju Lee, Nu-Ri Choi, Manh-Cuong Vo, My-Dung Hoang, Youn-Kyung Lee, and Je-Jung Lee

3. Pulsing Dendritic Cells with Whole Tumor Cell Lysates

Laura Alaniz, Manglio M. Rizzo, and Guillermo Mazzolini

4. Antigen Trapping by Dendritic Cells for Anti-Tumor Therapy

Chiranjib Pal

5. Ex Vivo Loading of Autologous Dendritic Cells with Tumor Antigens

Manglio M. Rizzo, Laura Alaniz, and Guillermo Mazzolini

6. Tumor Antigen/Cytokine-Pulsed Dendritic Cells in Therapy Against Lymphoma

Sumit K. Hira, Deepak Verma, and Partha P. Manna

7. Dendritic Cells Primed with Protein-Protein Fusion Adjuvant

Liying Wang and Yongli Yu

8. Antigen-Specific mRNA Transfection of Autologous Dendritic Cells

Fabian Benencia

9. Electroporation of Dendritic Cells with Autologous Total RNA from Tumor Material

Francesca Milano and K.K. Krishnadath

10. Dendritic Cells Transfected with Adenoviral Vectors as Vaccines

Joseph Senesac, Dmitry Gabrilovich, Samuel Pirruccello, and James E. Talmadge

11. Genetic Modification of Dendritic Cells with RNAi

Xiao-Tong Song

12. Fast Monocyte-Derived Dendritic Cells-Based Immunotherapy

Gamal Ramadan

13. Intratumoral Injection of BCG-CWS Pretreated Dendritic Cells Following Tumor Cryoablation

Naoshi Kawamura, Masaru Udagawa, Tomonobu Fujita, Toshiharu Sakurai, Tomonori Yaguchi, and Yutaka Kawakami

14. Exploiting the CD1d-iNKT Cell Axis for Potentiation of DC-Based Cancer Vaccines

Roeland Lameris, Famke L. Schneiders, Tanja D. de Gruijl, and Hans J. van der Vliet

Part II: Manipulation and Modification of Immune Cells: T Lymphocytes and NK Cells

15. Modification of T Lymphocytes to Express Tumor Antigens

Aaron E. Foster and Xiao-Tong Song

16. Genetic Modification of Mouse Effector and Helper T Lymphocytes Expressing a Chimeric Antigen Receptor

Liza B. John, Tess M. Chee, David E. Gilham, and Phillip K. Darcy

17. Genetic Modification of Cytotoxic T Lymphocytes to Express Cytokine Receptors

Serena K. Perna, Barbara Savoldo, and Gianpietro Dotti

18. Monitoring the Frequency and Function of Regulatory T Cells and Summary of the Approaches Currently Used to Inhibit Regulatory T Cells in Cancer Patients

Chiara Camisaschi, Marcella Tazzari, Licia Rivoltini, and Chiara Castelli

19. Cytokine Activation of Natural Killer Cells

Syh-Jae Lin, Pei-Tzu Lee, and Ming-Ling Kuo

Part III: Manipulation and Modification of Tumor Cells

20. Loading of Acute Myeloid Leukemia Cells with Poly(I: C) by Electroporation

Eva Lion, Charlotte M. de Winde, Viggo F.I. Van Tendeloo, and Evelien L.J.M. Smits

21. Autologous Tumor Cells Engineered to Express Bacterial Antigens

Vijayakumar K. Ramiya, Maya M. Jerald, Patricia D. Lawman, and Michael J.P. Lawman

22. Tumor Cell Transformation Using Antisense Oligonucleotide

Mohamed R. Akl and Nehad M. Ayoub

23. The Direct Display of Costimulatory Proteins on Tumor Cells as a Means of Vaccination for Cancer Immunotherapy

Haval Shirwan, Esma S. Yolcu, Rajesh K. Sharma, Hong Zaho, and Orlando Grimany-Nuno

Part IV: Manipulation of Immune/Tumor Interactions

24. Cloning Variable

Автор: Ashley Vaughan
Название: Malaria Vaccines
ISBN: 1493949020 ISBN-13(EAN): 9781493949021
Издательство: Springer
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Описание: The chapters within this book talk about interventions concerning all aspects of life cycle progression--measuring antibody responses to blood stage parasite survival, the T Cell responses engendered by attenuated sporozoite vaccinations, and the unique effect on transmission of antibodies that target the mosquito stage of the life cycle.

Автор: Josef Thalhamer; Richard Weiss; Sandra Scheiblhofe
Название: Gene Vaccines
ISBN: 3709119294 ISBN-13(EAN): 9783709119297
Издательство: Springer
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Описание: The induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research. After a first hype, evoked by the fascinating options of this method, clinical studies did not reach the ambitious aims and a phase of disillusion ensued. It became obvious that Gene vaccines displayed a weaker immunogenicity in humans than had been observed in the mouse models. Meanwhile these hurdles have been overcome and gene vaccines undergo a renaissance. The present book gives an update of the “world of naked gene vaccines”, namely DNA and RNA vaccines. Its content ranges from general mechanisms, inherent immunostimulatory properties and the vast potential to modulate immune responses, to recent successful clinical studies and approved veterinary gene vaccines. Beyond the state-of-the-art of genetic immunization, the reader will be stimulated with a chapter addressing “burning questions”.

Автор: Larry J. Anderson; Barney S. Graham
Название: Challenges and Opportunities for Respiratory Syncytial Virus Vaccines
ISBN: 3662521555 ISBN-13(EAN): 9783662521557
Издательство: Springer
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Описание: Although respiratory syncytial virus (RSV) has been a high priority for vaccine development for over 50 years now, still no vaccine is available and none has yet demonstrated sufficient promise to move to licensure.

Автор: Andrew W. Artenstein
Название: Vaccines: A Biography
ISBN: 1489983627 ISBN-13(EAN): 9781489983626
Издательство: Springer
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Описание: Why another book about vaccines? There are already a few extremely well-written medical textbooks that provide comprehensive, state-of-the-art technical reviews regarding vaccine science. Additionally, in the past decade alone, a number of engrossing, provocative books have been published on various related issues ra- ing from vaccines against specific diseases to vaccine safety and policy. Yet there remains a significant gap in the literature – the history of vaccines. Vaccines: A Biography seeks to fill a void in the extant literature by focusing on the history of vaccines and in so doing, recounts the social, cultural, and scientific history of vaccines; it places them within their natural, historical context. The book traces the lineage – the “biography” – of individual vaccines, originating with deeply rooted medical problems and evolving to an eventual conclusion. Nonetheless, these are not “biographies” in the traditional sense; they do not trace an individual’s growth and development. Instead, they follow an idea as it is conceived and dev- oped, through the contributions of many. These are epic stories of discovery, of risk-takers, of individuals advancing medical science, in the words of the famous physical scientist Isaac Newton, “by standing on the shoulders of giants. ” One grant reviewer described the book’s concept as “triumphalist”; although meant as an indictment, this is only partially inaccurate.