RNA Folding, Christina Waldsich

Автор: B?atrice Clouet-d`Orval
Название: RNA Metabolism and Gene Expression in Archaea
ISBN: 3319657941 ISBN-13(EAN): 9783319657943
Издательство: Springer
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Описание: This book focuses on the regulation of transcription and translation in Archaea and arising insights into the evolution of RNA processing pathways. Topics covered include the modification and maturation of RNAs, the function of small non-coding RNAs and the CRISPR-Cas defense system.

Автор: Kathryn Sandberg; Susan E. Mulroney
Название: RNA Binding Proteins
ISBN: 1441949356 ISBN-13(EAN): 9781441949356
Издательство: Springer
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Цена: 34799.00 р.
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Описание: RNA binding proteins are an exciting area of research in gene regulation. Unlike DNA, the structure of RNA is highly variable and conformationally flexible, thus creating a number of unique binding sites and the potential for complex regulation by RNA binding proteins.

Автор: Rick Russell
Название: Biophysics of RNA Folding
ISBN: 1489988947 ISBN-13(EAN): 9781489988942
Издательство: Springer
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Цена: 22359.00 р.
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Описание: This volume, written by experts in the field, discusses the current understanding of the biophysical principles that govern RNA folding, with featured RNAs including the ribosomal RNAs, viral RNAs, and self-splicing introns. In addition to the fundamental features of RNA folding, the central experimental and computational approaches in the field are presented with an emphasis on their individual strengths and limitations, and how they can be combined to be more powerful than any method alone; these approaches include NMR, single molecule fluorescence, site-directed spin labeling, structure mapping, comparative sequence analysis, graph theory, course-grained 3D modeling, and more. This volume will be of interest to professional researchers and advanced students entering the field of RNA folding.

Автор: Ane Sesma; Tobias von der Haar
Название: Fungal RNA Biology
ISBN: 3319056867 ISBN-13(EAN): 9783319056869
Издательство: Springer
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Описание: RNA polymerase II-dependent transcription in fungi and its interplay with mRNA decay.- Pre-mRNA splicing and the spliceosome: assembly, catalysis and fidelity.- Fungal pre-mRNA 3' end processing.- mRNA export.- mRNA translation: Fungal variations on a eukaryotic theme.- mRNA localization.- mRNA degradation and decay.- Cytoplasmic mRNA surveillance pathways.- Making Ribosomes: pre-rRNA Transcription and Processing.- Biogenesis and evolution of functional tRNAs.- Small RNA-mediated gene silencing in Neurospora.- The RNAi machinery in Mucorales: the emerging role of endogenous small RNAs.- Regulation of pericentric heterochromatin by ncRNA in Schizosaccharomyces pombe.- Approaches for dissecting RNA-binding protein networks.- Bioinformatic tools for Next-Generation RNA sequencing analysis.

Автор: M. Lucrecia Alvarez; Mahtab Nourbakhsh
Название: RNA Mapping
ISBN: 1493953869 ISBN-13(EAN): 9781493953868
Издательство: Springer
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Цена: 15372.00 р.
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Описание: In RNA Mapping- Methods and Protocols expert researchers in the field detail many of the methods which are now commonly used to study RNA.

Автор: Volker A. Erdmann; Stefan Jurga; Jan Barciszewski
Название: RNA and DNA Diagnostics
ISBN: 3319173049 ISBN-13(EAN): 9783319173047
Издательство: Springer
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Цена: 20962.00 р.
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Описание: The aim of molecular diagnostics is preferentially to detect a developing disease before any symptoms appear. There has been a significant increase, fueled by technologies from the human genome project, in the availability of nucleic acid sequence information for all living organisms including bacteria and viruses. When combined with a different type of instrumentation applied, the resulting diagnostics is specific and sensitive. Nucleic acid-based medical diagnosis detects specific DNAs or RNAs from the infecting organism or virus and a specific gene or the expression of a gene associated with a disease. Nucleic acid approaches also stimulate a basic science by opening lines of inquiry that will lead to greater understanding of the molecules at the center of life. One can follow Richard Feynman’s famous statement “What I cannot create, I do not understand.”

Автор: Mathias Munschauer
Название: High-Resolution Profiling of Protein-RNA Interactions
ISBN: 3319162527 ISBN-13(EAN): 9783319162522
Издательство: Springer
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Описание: The work reported in this book represents an excellent example of how creative experimentation and technology development, complemented by computational data analysis, can yield important insights that further our understanding of biological entities from a systems perspective. The book describes how the study of a single RNA-binding protein and its interaction sites led to the development of the novel ‘protein occupancy profiling’ technology that for the first time captured the mRNA sequence space contacted by the ensemble of expressed RNA binders. Application of protein occupancy profiling to eukaryotic cells revealed that extensive sequence stretches in 3’ UTRs can be contacted by RBPs and that evolutionary conservation as well as negative selection act on protein-RNA contact sites, suggesting functional importance. Comparative analysis of the RBP-bound sequence space has the potential to unravel putative cis-acting RNA elements without a priori knowledge of the bound regulators. Here, Dr. Munschauer provides a comprehensive introduction to the field of post-transcriptional gene regulation, examines state-of-the-art technologies, and combines the conclusions from several journal articles into a coherent and logical story from the frontiers of systems-biology inspired life science. This thesis, submitted to the Department of Biology, Chemistry and Pharmacy at Freie Universit?t Berlin, was selected as outstanding work by the Berlin Institute for Medical Systems Biology at the Max-Delbrueck Center for Molecular Medicine, Germany.