Targeted Genome Editing Using Site-Specific Nucleases, Takashi Yamamoto
Автор: Yamamoto, Takashi Название: Targeted Genome Editing Using Site-Specific Nucleases ISBN: 443155226X ISBN-13(EAN): 9784431552260 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book serves as an introduction to targeted genome editing, beginning with the background of this rapidly developing field and methods for generation of engineered nucleases. Applications of genome editing tools are then described in detail, in iPS cells and diverse organisms such as mice, rats, marine invertebrates, fish, frogs, and plants. Tools that are mentioned include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR/Cas9, all of which have received much attention in recent years as breakthrough technologies. Genome editing with engineered nucleases allows us to precisely change the target genome of living cells and is a powerful way to control functional genes. It is feasible in almost all organisms ranging from bacteria to plants and animals, as well as in cultured cells such as ES and iPS cells. Various genome modifications have proven successful, including gene knockout and knock-in experiments with targeting vectors and chromosomal editing. Genome editing technologies hold great promise for the future, for example in biomedical research, clinical medicine, and generation of crops and livestock with desirable traits. A wide range of readers will find this book interesting, and with its focus on applications in a variety of organisms and cells, the book will be valuable for life scientists in all fields.
Автор: Toni Cathomen; Matthew Hirsch; Matthew Porteus Название: Genome Editing ISBN: 1493935070 ISBN-13(EAN): 9781493935079 Издательство: Springer Рейтинг: Цена: 19591.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: "American Society of Gene & Cell Therapy"--Cover.
Автор: Turksen Название: Genome Editing ISBN: 3319341464 ISBN-13(EAN): 9783319341460 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This timely volume explores the use of CRISPR-Cas9 for genome editing, presenting cutting-edge techniques and their applications in treatment of disease. The chapters describe latest methods such as use of targetable nucleases, investigation of the non-coding genome, mouse genome editing, increasing of knock-in efficiency in mouse zygotes, and generation of reporter stem cells; the text contextualizes these methods in treatment of cardiovascular disease, diabetes mellitus, retinitis pigmentosa, and others. The final chapters round out the book with a discussion of controversies and future directions.
Genome Editing is an essential, of-the-moment contribution to this rapidly growing field. Drawing from a wealth of international perspectives, it presents novel techniques and applications for the engineering of the human genome. This book is essential reading for all clinicians and researchers in stem cells, regenerative medicine, genomics, biochemical and biomedical engineering- especially those interested in learning more about genome editing and applying it in a targeted, specific way.
Автор: Feng Zhang; Holger Puchta; James G. Thomson Название: Advances in New Technology for Targeted Modification of Plant Genomes ISBN: 1493925555 ISBN-13(EAN): 9781493925551 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Over the past 50 years, biotechnology has been the major driving force for increasing crop productivity. Particularly, advances in plant genetic engineering technologies have opened up vast new opportunities for plant researchers and breeders to create new crop varieties with desirable traits. Recent development of precise genome modification methods, such as targeted gene knock-out/knock-in and precise gene replacement, moves genetic engineering to another level and offers even more potentials for improving crop production. The work provides an overview of the latest advances on precise genomic engineering technologies in plants. Topics include recombinase and engineered nucleases-mediated targeted modification, negative/positive selection-based homologous recombination and oligo nucleotide-mediated recombination. Finally, challenges and impacts of the new technologies on present regulations for genetic modification organisms (GMOs) will be discussed.
Автор: G?nther Witzany Название: Biocommunication and Natural Genome Editing ISBN: 9048133181 ISBN-13(EAN): 9789048133185 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides a uniform description of all key levels of communication in the organismic kingdoms of plants, fungi, animals, bacteria and additionally the natural genome editing competences of viruses based on the most recent empirical data.
Автор: Amanda Tivnan Название: Resistance to Targeted Therapies Against Adult Brain Cancers ISBN: 331946504X ISBN-13(EAN): 9783319465043 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.
Автор: Francesco Colotta; Alberto Mantovani Название: Targeted Therapies in Cancer: ISBN: 1441925376 ISBN-13(EAN): 9781441925374 Издательство: Springer Рейтинг: Цена: 20896.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This crucial text offers readers an overview of diverse approaches to targeted cancer therapies, ranging from drug discovery to cellular therapy. Overall, the book addresses the key question of whether ultimately targeted therapy in cancer will be a myth or a reality.
Автор: Rudolf Jaenisch; Feng Zhang; Fred Gage Название: Genome Editing in Neurosciences ISBN: 3319601911 ISBN-13(EAN): 9783319601915 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is open access under a CC BY 4.0 license.
CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease.
This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.
Автор: Mark J. van der Laan; Sherri Rose Название: Targeted Learning in Data Science ISBN: 3319653032 ISBN-13(EAN): 9783319653037 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This textbook for graduate students in statistics, data science, and public health deals with the practical challenges that come with big, complex, and dynamic data.
Автор: Peter J. Houghton; Robert J. Arceci Название: Molecularly Targeted Therapy for Childhood Cancer ISBN: 148998142X ISBN-13(EAN): 9781489981424 Издательство: Springer Рейтинг: Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Each chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular `drivers` can be exploited from a therapeutic standpoint with currently available targeted agents.
Автор: G?nther Witzany Название: Biocommunication and Natural Genome Editing ISBN: 9400791143 ISBN-13(EAN): 9789400791145 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides a uniform description of all key levels of communication in the organismic kingdoms of plants, fungi, animals, bacteria and additionally the natural genome editing competences of viruses based on the most recent empirical data.
Описание: This book encompasses a decade of explosive growth in knowledge of the pathobiology of hematologic cancer, and offers the insight of experts from around the world on current treatment approaches and on future progress in malignant hematologic diseases.
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