RNA and DNA Diagnostics, Volker A. Erdmann; Stefan Jurga; Jan Barciszewski

Автор: Volker A. Erdmann; Stefan Jurga; Jan Barciszewski
Название: RNA and DNA Diagnostics
ISBN: 3319173049 ISBN-13(EAN): 9783319173047
Издательство: Springer
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Цена: 20962.00 р.
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Описание: The aim of molecular diagnostics is preferentially to detect a developing disease before any symptoms appear. There has been a significant increase, fueled by technologies from the human genome project, in the availability of nucleic acid sequence information for all living organisms including bacteria and viruses. When combined with a different type of instrumentation applied, the resulting diagnostics is specific and sensitive. Nucleic acid-based medical diagnosis detects specific DNAs or RNAs from the infecting organism or virus and a specific gene or the expression of a gene associated with a disease. Nucleic acid approaches also stimulate a basic science by opening lines of inquiry that will lead to greater understanding of the molecules at the center of life. One can follow Richard Feynman’s famous statement “What I cannot create, I do not understand.”

Автор: Jensen
Название: RNA Exosome
ISBN: 1441978402 ISBN-13(EAN): 9781441978400
Издательство: Springer
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Цена: 22359.00 р.
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Описание: Assembling work by prominent researchers in the field of RNA exosomes, this excellent introduction to the fascinating protein complex provides a comprehensive account of the proteins` many functions as well as a historical account of the field`s development.

Автор: Howard
Название: RNA Interference from Biology to Therapeutics
ISBN: 1461447437 ISBN-13(EAN): 9781461447436
Издательство: Springer
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Цена: 28734.00 р.
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Описание: This volume addresses the role of different RNAi molecules in cellular processes as rational for diagnostic and therapeutic approaches. It covers RNAi therapeutic design to optimize siRNA potency and reduce off-target effects.

Автор: Jir? ?poner; Filip Lanka?
Название: Computational studies of RNA and DNA
ISBN: 9048171954 ISBN-13(EAN): 9789048171958
Издательство: Springer
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Цена: 36570.00 р.
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Описание: This book integrates modern computational studies of nucleic acids, ranging from advanced electronic structure quantum chemical calculations through explicit solvent molecular dynamics (MD) simulations up to mesoscopic modelling, with the main focus given to the MD field.

Автор: B. Meunier
Название: DNA and RNA Cleavers and Chemotherapy of Cancer and Viral Diseases
ISBN: 9401065969 ISBN-13(EAN): 9789401065962
Издательство: Springer
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Цена: 18167.00 р.
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Описание: Proceedings of the NATO Advanced Research Workshop on `DNA and RNA Cleavers and Chemotherapy of Cancer and Viral Diseases`, Toulouse, France, September 11-14, 1995

Автор: Volker A. Erdmann; Jan Barciszewski
Название: DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases
ISBN: 3642368522 ISBN-13(EAN): 9783642368523
Издательство: Springer
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Цена: 26122.00 р.
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Описание: This book covers the design and synthesis of DNA and RNA nanostructures with the aim of using them for drug deliveries, for genetic immunization, for metabolite and nucleic acid detection, gene regulation, and siRNA delivery for cancer treatment.

Автор: Volker A. Erdmann; Jan Barciszewski
Название: DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases
ISBN: 3642443524 ISBN-13(EAN): 9783642443527
Издательство: Springer
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Цена: 23508.00 р.
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Описание: This book covers the design and synthesis of DNA and RNA nanostructures with the aim of using them for drug deliveries, for genetic immunization, for metabolite and nucleic acid detection, gene regulation, and siRNA delivery for cancer treatment.

Автор: Hans-Joachim Anders; Adriana Migliorini
Название: Innate DNA and RNA Recognition
ISBN: 1493945831 ISBN-13(EAN): 9781493945832
Издательство: Springer
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Цена: 14673.00 р.
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Описание:

Part I: Analysis of Viral Nucleic Acid Sensing In-Silico and In-Vitro

1. Detection of RNA Modifications by HPLC Analysis and Competitive ELISA

Gernot Nees, Andreas Kaufmann and Stefan Bauer

2. Enzymatic Synthesis and Purification of a Defined RIG-I Ligand

Marion Goldeck, Martin Schlee, Gunther Hartmann, and Veit Hornung

3. Crystallization of Mouse RIG-I ATPase Domain: In situ Proteolysis

Filiz Civril and Karl-Peter Hopfner

4. Isolation of RIG-I-associated RNAs from Virus Infected Cells

Andreas Schmidt, Andreas Linder, Nicolas Linder, and Simon Rothenfu er

5. Structure Modeling of Toll-like Receptors

Jing Gong and Tiandi Wei

6. Nucleic Acid Recognition in Dendritic Cells

Alexander Heiseke, Katharina Eisenдcher, and Anne Krug

7. Viral Nucleic Acid Recognition in Human Non-immune cells: In vitro Systems

Andrea Ribeiro and Markus Wцrnle

8. Analysis of Nucleic Acid-induced Non-immune Cell Death in Vitro

Simone Romoli, Adriana Migliorini

9. In vitro Analysis of Nucleic Acid Recognition in B Lymphocytes

Saskia Ziegler and Isabelle Bekeredjian-Ding

10. Mapping of Optimal CD8 T Cell Epitopes

Julia Roider, Thomas Vollbrecht and Rika Draenert

11. A Modular Approach to Suppression Ass says: TLR-Ligands, Conditioned Medium, and Viral Infection

Viktor H. Koelzer and David Anz

Автор: Mouldy Sioud
Название: RNA Therapeutics
ISBN: 1493961519 ISBN-13(EAN): 9781493961511
Издательство: Springer
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Цена: 18167.00 р.
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Описание: Central to the synthesis of proteins, the performance of catalysis, and many other physiological processes, the aberrant expression of which can be linked to human diseases including cancers, RNA has proven to be key target for therapeutics as well as a tool for therapy. In RNA Therapeutics: Function, Design, and Delivery, expert contributors from a broad spectrum of scientific backgrounds highlight the roles that messenger RNAs and small RNAs can play in biology and medicine. While covering the five major RNA-based drugs, namely the use of ribozymes to cleave and/or correct mRNA transcript, the use of siRNA for targeted silencing of gene transcripts, the use of aptamers, like short RNA molecules, for neutralizing the protein functions, the use mRNA-transfected DCs to activate immune system against tumor cells, as well as the use of RNA to reprogram T and/or DC cell function, this extensive volume brings together the fields of coding (mRNA) and non-coding RNA such as ribozymes, RNAse P, siRNAs, and miRNAs into one convenient source. Written in the highly successful Methods in Molecular Biology™ series format, the cutting-edge protocol chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and practical tips on troubleshooting and avoiding known pitfalls. Also, the book contains several excellent reviews for teaching purposes. Authoritative and comprehensive, RNA Therapeutics: Function, Design, and Delivery provides key models and tools which will assist researchers in increasing our understanding of RNA functions, modifications, and their involvement in diseases in order to lead to the design of vital new RNA-based therapeutics.

Автор: Wei-Ping Min; Thomas Ichim
Название: RNA Interference
ISBN: 1493961349 ISBN-13(EAN): 9781493961344
Издательство: Springer
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Цена: 23058.00 р.
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Описание: The field of RNA interference has grown at a breakneck pace. In RNA Interference: From Biology to Clinical Applications, expert contributors provide a refreshing overview of the current science and protocols that span the biological disciplines of this field.

Автор: Ane Sesma; Tobias von der Haar
Название: Fungal RNA Biology
ISBN: 3319350110 ISBN-13(EAN): 9783319350110
Издательство: Springer
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Цена: 20896.00 р.
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Описание: RNA polymerase II-dependent transcription in fungi and its interplay with mRNA decay.- Pre-mRNA splicing and the spliceosome: assembly, catalysis and fidelity.- Fungal pre-mRNA 3' end processing.- mRNA export.- mRNA translation: Fungal variations on a eukaryotic theme.- mRNA localization.- mRNA degradation and decay.- Cytoplasmic mRNA surveillance pathways.- Making Ribosomes: pre-rRNA Transcription and Processing.- Biogenesis and evolution of functional tRNAs.- Small RNA-mediated gene silencing in Neurospora.- The RNAi machinery in Mucorales: the emerging role of endogenous small RNAs.- Regulation of pericentric heterochromatin by ncRNA in Schizosaccharomyces pombe.- Approaches for dissecting RNA-binding protein networks.- Bioinformatic tools for Next-Generation RNA sequencing analysis.

Автор: Jan Gorodkin; Walter L. Ruzzo
Название: RNA Sequence, Structure, and Function: Computational and Bioinformatic Methods
ISBN: 1493961659 ISBN-13(EAN): 9781493961658
Издательство: Springer
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Цена: 23058.00 р.
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Описание: The existence of genes for RNA molecules not coding for proteins (ncRNAs) has been recognized since the 1950's, but until recently, aside from the critically important ribosomal and transfer RNA genes, most focus has been on protein coding genes. However, a long series of striking discoveries, from RNA's ability to carry out catalytic function, to discovery of riboswitches, microRNAs and other ribo-regulators performing critical tasks in essentially all living organisms, has created a burgeoning interest in this primordial component of the biosphere. However, the structural characteristics and evolutionary constraints on RNA molecules are very different from those of proteins, necessitating development of a completely new suite of informatic tools to address these challenges. In RNA Sequence, Structure, Function: Computational and Bioinformatic Methods, expert researchers in the field describe a substantial and relevant fraction of these methodologies from both practical and computational/algorithmic perspectives. Focusing on both of these directions addresses both the biologist interested in knowing more about RNA bioinformatics as well as the bioinformaticist interested in more detailed aspects of the algorithms. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results. Thorough and intuitive, RNA Sequence, Structure, Function: Computational and Bioinformatic Methods aids scientists in continuing to study key methods and principles of RNA bioinformatics.