Описание: This third edition of Primary Immunodeficiency Diseases provides readers with the historic and scientific background, clinical presentations, immunologic characteristics, and the molecular/genetic underpinnings of this rapidly enlarging class of diseases.
Автор: Strachan, Tom Название: Human Molecular Genetics 4e ISBN: 0815341490 ISBN-13(EAN): 9780815341499 Издательство: Taylor&Francis Рейтинг: Цена: 8881.00 р. Наличие на складе: Поставка под заказ.
Описание: This revised and updated fourth edition bridges the gap between introductory textbooks and research papers, emphasizing underlying concepts and principles throughout. The book has been restructured so that discussion of genomic technologies is integrated into the text. A new section that concentrates on genetic testing, screening, and disease models has been added. Coverage of stem cells, cell senescence/immortalization, cell signalling, epigenetics, studying gene function, and model organisms has been expanded.
Автор: Konrad Beyreuther; Gotthard Schettler Название: Molecular Mechanisms of Aging ISBN: 354052732X ISBN-13(EAN): 9783540527329 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A high-level text on the molecular and genetic aspects of human ageing with reference to cognitive functions and age-related diseases.
Автор: Nilanjana Maulik; Tom Karagiannis Название: Molecular mechanisms and physiology of disease ISBN: 1493946234 ISBN-13(EAN): 9781493946235 Издательство: Springer Рейтинг: Цена: 32142.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.
Описание: This Methods in Molecular Biology book details approaches for the detection of DNA and RNA including recovery of trace amounts of DNA for amplification and analysis, new qPCR chemistries, step-by-step, reproducible protocols, materials lists, tips and more.
Описание: Continued refinement of wide-spread access to transgenic technology has allowed for new animal models have been developed that exhibit features of autoimmune disease have been developed that exhibit features of autoimmune disease.
Автор: Shamim Ahmad; Sandra Kirk Название: Molecular Mechanisms of Fanconi Anemia ISBN: 1489998748 ISBN-13(EAN): 9781489998743 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Molecular Mechanisms of Fanconi Anemia will give research students a platform for further investigation, and act as a source of information regarding experimental design. Clinicians will find this title useful for its comprehensive description of Fanconi Anemia and information on the latest molecular theories underlying its causes.
Автор: Yigal H. Ehrlich Название: Molecular and Cellular Mechanisms of Neuronal Plasticity ISBN: 1461372097 ISBN-13(EAN): 9781461372097 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the Neuroscience Symposium held in Staten Island of The City University of New York, and The CSI/IBR Center for Developmental Neuroscience, Staten Island, NY, and The City University Graduate School, New York City
Автор: Hartmut Geiger (Editor), Jasper Heinrich (Editor), Название: Stem Cell Aging: Mechanisms, Consequences, Rejuvenation ISBN: 3709112311 ISBN-13(EAN): 9783709112311 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis, like the skin, blood and intestines. Understanding the molecular and cellular mechanisms involved is critical for developing approaches to attenuate stem cell aging and could pave the way for improved quality of life among the elderly. Written by highly prominent experts in the field, this book presents the current state of knowledge on these mechanisms. It offers insights into stem cell function, explains in detail the mechanisms of stem cell aging in model organisms as well as mammalian systems and describes related diseases and approaches to attenuating stem cell aging or achieving rejuvenation. The book is intended for all scientists and clinicians working with stem cells, aging mechanisms or age-related diseases.
Автор: Brad A. Amendt Название: The Molecular Mechanisms of Axenfeld-Rieger Syndrome ISBN: 1489996648 ISBN-13(EAN): 9781489996640 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Identification of the Gene Involved in 4q25-Linked Axenfeld-Rieger Syndrome, PITX2.- Winged Helix/Forkhead Transcription Factors and Rieger Syndrome.- Rieger Syndrome and PAX6 Deletion.- The Molecular and Biochemical Basis of Axenfeld-Rieger Syndrome.- Role of PITX2 in the Pituitary Gland.- Expression and Function of Pitx2 in Chick Heart Looping.- The Multiple Roles of Pitx2 in Heart Development.- The Role of PITX2 in Tooth Development.- PITX Genes and Ocular Development.- An Overview of Axenfeld-Rieger Syndrome and the Anterior Segment Developmental Disorders.
Автор: Cl?vio N?brega; Raquel Rodriguez-L?pez Название: Molecular Mechanisms Underpinning the Development of Obesity ISBN: 3319376292 ISBN-13(EAN): 9783319376295 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Challenges in understanding development of obesity.- Monogenic forms of obesity.- Heterogeneous obesity syndromes: new strategies for diagnosis.- Genetic contribution: common forms of obesity.- The role of the GWAS identified FTO locus in regulating body size and composition.- Neural vulnerability factors that increase risk for weight gain: prevention and treatment implications.- Molecular mechanisms involved in the regulation of food intake.- Epigenetics of human obesity: a link between genetics and nutrition.- MicroRNAs in obesity and metabolism.- Obesity study: animal models.- From Homo obesus to Homo diabesus: neuroadipology insight.- Obesity and type 2 diabetes.
Автор: Maulik Название: Molecular mechanisms and physiology of disease ISBN: 1493907050 ISBN-13(EAN): 9781493907052 Издательство: Springer Рейтинг: Цена: 32142.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.
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