Molecular Mechanisms of Aging, Konrad Beyreuther; Gotthard Schettler

Автор: Hartmut Geiger (Editor), Jasper Heinrich (Editor),
Название: Stem Cell Aging: Mechanisms, Consequences, Rejuvenation
ISBN: 3709112311 ISBN-13(EAN): 9783709112311
Издательство: Springer
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Цена: 19564.00 р.
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Описание: Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis, like the skin, blood and intestines. Understanding the molecular and cellular mechanisms involved is critical for developing approaches to attenuate stem cell aging and could pave the way for improved quality of life among the elderly. Written by highly prominent experts in the field, this book presents the current state of knowledge on these mechanisms. It offers insights into stem cell function, explains in detail the mechanisms of stem cell aging in model organisms as well as mammalian systems and describes related diseases and approaches to attenuating stem cell aging or achieving rejuvenation. The book is intended for all scientists and clinicians working with stem cells, aging mechanisms or age-related diseases.

Автор: Cl?vio N?brega; Raquel Rodriguez-L?pez
Название: Molecular Mechanisms Underpinning the Development of Obesity
ISBN: 3319376292 ISBN-13(EAN): 9783319376295
Издательство: Springer
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Цена: 15672.00 р.
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Описание: Challenges in understanding development of obesity.- Monogenic forms of obesity.- Heterogeneous obesity syndromes: new strategies for diagnosis.- Genetic contribution: common forms of obesity.- The role of the GWAS identified FTO locus in regulating body size and composition.- Neural vulnerability factors that increase risk for weight gain: prevention and treatment implications.- Molecular mechanisms involved in the regulation of food intake.- Epigenetics of human obesity: a link between genetics and nutrition.- MicroRNAs in obesity and metabolism.- Obesity study: animal models.- From Homo obesus to Homo diabesus: neuroadipology insight.- Obesity and type 2 diabetes. ​

Автор: Zhao-Wen Wang
Название: Molecular Mechanisms of Neurotransmitter Release
ISBN: 1627038841 ISBN-13(EAN): 9781627038843
Издательство: Springer
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Цена: 28732.00 р.
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Описание: The aim of Molecular Mechanisms of Neurotransmitter Release is to provide up-to-date, in-depth coverage of essentially all major mole- lar mechanisms of neurotransmitter release.

Автор: Brad A. Amendt
Название: The Molecular Mechanisms of Axenfeld-Rieger Syndrome
ISBN: 1489996648 ISBN-13(EAN): 9781489996640
Издательство: Springer
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Цена: 19564.00 р.
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Описание: Identification of the Gene Involved in 4q25-Linked Axenfeld-Rieger Syndrome, PITX2.- Winged Helix/Forkhead Transcription Factors and Rieger Syndrome.- Rieger Syndrome and PAX6 Deletion.- The Molecular and Biochemical Basis of Axenfeld-Rieger Syndrome.- Role of PITX2 in the Pituitary Gland.- Expression and Function of Pitx2 in Chick Heart Looping.- The Multiple Roles of Pitx2 in Heart Development.- The Role of PITX2 in Tooth Development.- PITX Genes and Ocular Development.- An Overview of Axenfeld-Rieger Syndrome and the Anterior Segment Developmental Disorders.

Автор: Shamim Ahmad; Sandra Kirk
Название: Molecular Mechanisms of Fanconi Anemia
ISBN: 1489998748 ISBN-13(EAN): 9781489998743
Издательство: Springer
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Цена: 19589.00 р.
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Описание: Molecular Mechanisms of Fanconi Anemia will give research students a platform for further investigation, and act as a source of information regarding experimental design. Clinicians will find this title useful for its comprehensive description of Fanconi Anemia and information on the latest molecular theories underlying its causes.

Автор: Nilanjana Maulik; Tom Karagiannis
Название: Molecular mechanisms and physiology of disease
ISBN: 1493946234 ISBN-13(EAN): 9781493946235
Издательство: Springer
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Цена: 32142.00 р.
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Описание: In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.

Автор: Michel Lebel
Название: Molecular Mechanisms of Werner`s Syndrome
ISBN: 0306482339 ISBN-13(EAN): 9780306482335
Издательство: Springer
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Цена: 18167.00 р.
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Описание: During our short time on earth, we all undergo the highly complex process of aging, and with it, we experience the many physiological symptoms. Studies of premature aging have produced a deal of information that gives some aspects of aging a better understanding. This book explores Werner`s syndrome.

Автор: Michel Lebel
Название: Molecular Mechanisms of Werner`s Syndrome
ISBN: 1461347661 ISBN-13(EAN): 9781461347668
Издательство: Springer
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Цена: 13974.00 р.
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Описание: To some, Werner`s syndrome is considered a caricature of aging, but others will find it fascinating that only one mutated human gene (WRN) can bring about a multitude of complicated phenotypes that are usually associated with aging.

Автор: Wilma Wasco; Rudolph Tanzi
Название: Molecular Mechanisms of Dementia
ISBN: 1475758898 ISBN-13(EAN): 9781475758894
Издательство: Springer
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Цена: 15372.00 р.
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Автор: Yigal H. Ehrlich
Название: Molecular and Cellular Mechanisms of Neuronal Plasticity
ISBN: 1461372097 ISBN-13(EAN): 9781461372097
Издательство: Springer
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Цена: 20962.00 р.
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Описание: Proceedings of the Neuroscience Symposium held in Staten Island of The City University of New York, and The CSI/IBR Center for Developmental Neuroscience, Staten Island, NY, and The City University Graduate School, New York City

Автор: Maulik
Название: Molecular mechanisms and physiology of disease
ISBN: 1493907050 ISBN-13(EAN): 9781493907052
Издательство: Springer
Рейтинг:
Цена: 32142.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.