Описание: Highly regarded by both students and instructors, Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 4th Edition, offers an integrated mechanism-based and systems-based approach to contemporary pharmacology and drug development.
Автор: J. Clemmesen; A. Waring; D.M. Conning; D. Henschle Название: Quantitative Aspects of Risk Assessment in Chemical Carcinogenesis ISBN: 3540095845 ISBN-13(EAN): 9783540095842 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: N-nitroso-compounds form an important class of carcinogenic chemicals which may be of environmental importance (Druckrey et al., 1967; Magee et al., 1976; IARC, 1978). The mechanism by which these carcinogens initiate neoplastic growth is not well understood but there is substantial evidence favoring the hypothesis that the simple dialkylnitrosamines and alkylnitrosamides act by means of their conversion to al- kylating agents. Alkylating species are generated from the nitrosamines by metabolic activation and from the nitrosamides by chemical decomposition at physiological pH. It is widely believed that DNA is the critical alkylation target. Alkylation takes place at at least 12 sites within the DNA molecule (Lawley, 1976; Singer, 1976; Pegg, 1977a). Al- though alkylation at the 7-position of guanine is the most extensive reaction with the DNA bases and provides a reliable measurement of the degree of interaction with the carcinogen (Swann and Magee, 1968, 1971), recent experiments have suggested that alkylation of oxygen atoms may be the critical reaction (Goth and Rajewsky, 1974; Margison and Kleihues, 1975; Nicoll et aI., 1975; Pegg, 1977a). These laboratories have observed a correlation between the production and persistence of 06-alkyl- guanine and the occurrence oftumors in a variety of organs of rodents exposed to N-ni- troso-carcinogens. It has, therefore, been suggested that the ability of tissues to catalyze the removal of 06-alkylguanine from DNA may provide a protective mechanism against carcinogenesis.
Автор: Lemont B. Kier Название: Molecular Orbital Studies in Chemical Pharmacology ISBN: 354004972X ISBN-13(EAN): 9783540049722 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The lecturers at this symposium, all interested in molecular orbital theory, have backgrounds in pharmacology, physical chemistry, theoretical chemistry, bio- chemistry and medicinal chemistry.
Описание: Paul H. Axelsen concisely summarizes all the essential medical data concerning the leading antimicrobials used in fighting infectious diseases and clearly illustrates their mechanisms of action. The agents described range from antibacterial and antifungal to antiparasitic and antiviral agents, and include immunomodulators and immunizing agents. For each drug discussed, the book allows rapid access to the essential facts concerning its structure and mechanism of action, the spectrum of its activity, its pharmacokinetics, its adverse effects, and its resistance. This book provides medical students, physicians, and allied health professionals with rapid access to the core principles of antimicrobial pharmacology, and a foundation for decisions about the use of antimicrobials in daily practice.
Описание: This unique text helps students and healthcare professionals master the fundamentals of pharmacokinetics and pharmacodynamics. Written by distinguished international experts, it provides readers with an introduction to the basic principles underlying the establishment and individualization of dosage regimens and their optimal use in drug therapy. Up-to-date examples featuring currently prescribed drugs illustrate how pharmacokinetics and pharmacodynamics relate to contemporary drug therapy. Study problems at the end of each chapter help students and professionals gain a firm grasp of the material covered within the text.
Автор: Raffa, Robert Название: Netter`s Illustrated Pharmacology Updated Edition ISBN: 0323220916 ISBN-13(EAN): 9780323220910 Издательство: Elsevier Science Рейтинг: Цена: 7409.00 р. Наличие на складе: Поставка под заказ.
Описание: Offers a visual approach to understanding both the basic science and clinical applications of pharmacology. Designed to be compatible and used in conjunction with other pharmacology resources, this book includes a presentation of the pharmacodynamic relationship between drugs and the human body.
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