Physical Properties of Steroid Conjugates, Seymour Bernstein; J.P. Dusza; J.P. Joseph

Название: Antibody-drug conjugates
ISBN: 3319376691 ISBN-13(EAN): 9783319376691
Издательство: Springer
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Цена: 16977.00 р.
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Описание: Case studies are presented for the three ADCs that have received FDA approval: gemtuzumab ozogamicin (Mylotarg (R)), Brentuximab vedotin (Adcetris (R)), and ado-trastuzumab emtansine (Kadcyla (R)), as well as an ADC in late-stage clinical trials, glembatumumab vedotin (CDX-011).

Автор: Damelin Marc
Название: Innovations for Next-Generation Antibody-Drug Conjugates
ISBN: 3319781537 ISBN-13(EAN): 9783319781532
Издательство: Springer
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Цена: 20962.00 р.
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Описание: Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.

Автор: Helmut Schlaad
Название: Bio-synthetic Polymer Conjugates
ISBN: 3642445071 ISBN-13(EAN): 9783642445071
Издательство: Springer
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Цена: 28732.00 р.
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Описание: Polypeptide-Polymer Conjugates, by Henning Menzel Chemical Strategies for the Synthesis of Protein-Polymer Conjugates, by Bjorn Jung and Patrick Theato Glycopolymer Conjugates, by Ahmed M.

Автор: Ducry
Название: Antibody-Drug Conjugates
ISBN: 1627035400 ISBN-13(EAN): 9781627035408
Издательство: Springer
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Цена: 23757.00 р.
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Описание: This book presents detailed protocols for key antibody-drug conjugates techniques necessary for working in the field. It provides step-by-step methodologies that are readily reproducible and features expert tips and key implementation advice.

Автор: Helmut Schlaad
Название: Bio-synthetic Polymer Conjugates
ISBN: 364234349X ISBN-13(EAN): 9783642343490
Издательство: Springer
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Цена: 36570.00 р.
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Описание: Includes: "Polypeptide-Polymer Conjugates"; "Chemical Strategies for the Synthesis of Protein-Polymer Conjugates"; "Glycopolymer Conjugates"; "DNA-Polymer Conjugates: From Synthesis, Through Complex Formation and Self-assembly to Applications"; and, "Synthesis of Terpene-Based Polymers".

Автор: Ulf Grawunder; Stefan Barth
Название: Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins
ISBN: 3319468758 ISBN-13(EAN): 9783319468754
Издательство: Springer
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Цена: 20962.00 р.
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Описание:

This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities.

The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.

Автор: Gail Lewis Phillips
Название: Antibody-Drug Conjugates and Immunotoxins
ISBN: 1489997008 ISBN-13(EAN): 9781489997005
Издательство: Springer
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Цена: 22201.00 р.
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Описание: This volume collets leading research on antibody-drug conjugates and immunotoxins. It examines all aspects of ADCs and ITs from clinical development through to targeted therapeutic applications and the latest technologies.

Автор: Laurent Ducry
Название: Antibody-Drug Conjugates
ISBN: 1493960261 ISBN-13(EAN): 9781493960262
Издательство: Springer
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Цена: 16769.00 р.
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Описание: This book presents detailed protocols for key antibody-drug conjugates techniques necessary for working in the field. It provides step-by-step methodologies that are readily reproducible and features expert tips and key implementation advice.

Автор: L. Zhizhiashvili
Название: Trigonometric Fourier Series and Their Conjugates
ISBN: 0792340884 ISBN-13(EAN): 9780792340881
Издательство: Springer
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Цена: 15372.00 р.
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Описание: Research in the theory of trigonometric series has been carried out for over two centuries. The achievements in the theory of multiple trigonometric series look rather modest as compared to those in the one-dimensional case though multiple trigonometric series seem to be a natural, interesting and promising object of investigation.

Автор: L. Zhizhiashvili
Название: Trigonometric Fourier Series and Their Conjugates
ISBN: 9401066124 ISBN-13(EAN): 9789401066129
Издательство: Springer
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Цена: 15372.00 р.
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