Antibody Engineering Volume 1, Roland E. Kontermann; Stefan D?bel
Автор: Roland E. Kontermann; Stefan D?bel Название: Antibody Engineering Volume 2 ISBN: 3642422764 ISBN-13(EAN): 9783642422768 Издательство: Springer Рейтинг: Цена: 27550 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity. "Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest "hands on" knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody engineers will appreciate the new ideas and approaches. The book is an invaluable resource for all those engaged in antibody research and development.
Автор: Patrick Chames Название: Antibody Engineering ISBN: 1493959441 ISBN-13(EAN): 9781493959440 Издательство: Springer Рейтинг: Цена: 27550 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: More than ever, antibodies are being recognized as a major drug modality in a variety of diseases, including cancer, autoimmune diseases, infectious diseases, or even neurodegenerative disorders. Over 30 therapeutic antibodies have been approved and novel molecules are entering clinical trials at an average rate of 50 per year and that is predicted to continue well into the future. Notwithstanding the many achievements already made in the field, there is still a lot of room for improvements for these molecules in terms of activity, and a plethora of approaches have been attempted to optimize these molecules. Antibody Engineering: Methods and Protocols, Second Edition was compiled to give complete and easy access to a variety of antibody engineering techniques, starting from the creation of antibody repertoires and efficient ways to select binders from these repertoires, to their production in various hosts, their detailed characterization using various well established techniques, and to the modification and optimization of these lead molecules in terms of binding activity, specificity, size, shape, and more. Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Antibody Engineering: Methods and Protocols, Second Edition serves as an invaluable resource for both experts and those new to the field, and most of all as a source of inspiration for the creation of the antibodies of tomorrow.
Автор: Howard Название: Basic Methods in Antibody Production & Charact. ISBN: 0849394457 ISBN-13(EAN): 9780849394454 Издательство: Taylor&Francis Цена: 10538 р. Наличие на складе: Нет в наличии.
Описание: Written for researchers and professionals in the fields of biomedical research, immunology, biochemistry, molecular biology, pathology, and biotechnology, Basic Methods in Antibody Production and Characterization uses a cookbook approach to presenting the methods for the production, characterization, and use of antiboes. Antibodies described include polyclonal and monoclonal and those made by the phage display. Basic Methods in Antibody Production and Characterization focuses on specific aspects of antibodies and takes readers on a step-by-step process from antigen preparation to immunizations, adjuvants, screening, purification, storage, and applications.Introductory material accompanies each chapter, giving readers a better understanding of the methods and applications. Ample references arm researchers with many applications pertaining to the particular technology.
Автор: Benny K. C. Lo Название: Antibody Engineering ISBN: 1617373524 ISBN-13(EAN): 9781617373527 Издательство: Springer Рейтинг: Цена: 26785 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Despite this setback, advances in recombinant DNA techniques over the last 15-20 years have empowered the engineering of recombinant antibodies with desired characteristics, including properties to avoid HAMA.
Описание: In the anti-breast cancer antibody field the availability of molecular engineering approaches to humanize murine antibodies has induced intense interest in the creation of less immunogenic antibody forms that are now available for clinical testing.
Автор: Robert Aitken (Ed.) Название: Antibody Phage Display ISBN: 1603273018 ISBN-13(EAN): 9781603273015 Издательство: Springer Рейтинг: Цена: 24489 р. Наличие на складе: Нет в наличии.
Описание: Phage display technology has revolutionized approaches to the analysis of biomedical problems, impacting the fields of immunology, cell biology, biotechnology, pharmacology, and drug discovery. This title provides a resource that guides readers in the design and execution of experiments based around antibody phage display.
Автор: Mohamed Al-Rubeai Название: Antibody Expression and Production ISBN: 9400736134 ISBN-13(EAN): 9789400736139 Издательство: Springer Рейтинг: Цена: 31469 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book covers generation, optimization, characterization, production and applications of antibodies, offering theoretical background and describing methods for expression of antibody in microbial and animal cell cultures and transgenic animals and plants.
Автор: Ulf Grawunder; Stefan Barth Название: Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins ISBN: 3319468758 ISBN-13(EAN): 9783319468754 Издательство: Springer Рейтинг: Цена: 22958 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities.
The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.
Автор: Proetzel Название: Antibody Methods and Protocols ISBN: 1617799300 ISBN-13(EAN): 9781617799303 Издательство: Springer Рейтинг: Цена: 22958 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The rapidly growing field of antibody research is the result of many advancing technologies allowing current developments to take advantage of molecular engineering to create tailor-made antibodies. Antibody Methods and Protocols attempts to provide insight into the generation of antibodies using in vitro and in vivo approaches, as well as technical aspects for screening, analysis, and modification of antibodies and antibody fragments. The detailed volume is focused on basic protocols for isolating antibodies and, at the same time, it selects a range of specific areas with the aim of providing guides for the overall process of antibody isolation and characterization as well as protocols for enhancing classical antibodies and antibody fragments. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Antibody Methods and Protocols provides a broad and useful background to support ongoing efforts by novices and experts alike and encourages the development of new imaginative approaches to this vital area of study.
Автор: Roland E. Kontermann; Stefan D?bel Название: Antibody Engineering Volume 2 ISBN: 3642011462 ISBN-13(EAN): 9783642011467 Издательство: Springer Рейтинг: Цена: 35203 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is a toolbox of well-established basics and many exciting new techniques in antibody engineering, reflecting the latest hands-on work of key laboratories in this fast-moving field. The new edition is expanded to nearly double the number of protocols.
Автор: Roland E. Kontermann; Stefan D?bel Название: Antibody Engineering Volume 1 ISBN: 3642011438 ISBN-13(EAN): 9783642011436 Издательство: Springer Рейтинг: Цена: 45918 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is a toolbox of well-established basics and many exciting new techniques in antibody engineering, reflecting the latest hands-on work of key laboratories in this fast-moving field. The new edition is expanded to nearly double the number of protocols.
Автор: Borrebaeck, Carl A. K. Название: Antibody Engineering ISBN: 0195091507 ISBN-13(EAN): 9780195091502 Издательство: Oxford Academ Рейтинг: Цена: 14414 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This text has been designed to help researchers understand and develop designer antibodies. Its practical approach makes use of state-of-the-art technologies for the production of recombinant human or mouse monoclonal antibodies.
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