Adenovirus Methods and Protocols, William S. M. Wold; Ann E. Tollefson

Автор: Zachariou Michael
Название: Affinity Chromatography / Methods and Protocols
ISBN: 1588296598 ISBN-13(EAN): 9781588296597
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Описание: Thirty-eight years after its introduction, affinity chromatography remains a key tool in th armory of separation techniques available to separation and interaction scientists.  Expanded and updated from the first edition, this second edition volume aims to provide the beginner with the practical knowledge needed to develop affinity separations suitable for a variety of applications relevant to the post-genomic era.

Автор: Walter Doerfler
Название: Adenovirus DNA
ISBN: 0898387582 ISBN-13(EAN): 9780898387582
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Описание: Although adenoviruses have been established for quite some time as one of the most pliable tools to study the molecular biology of mammalian cells, rapid progress continues to be made with this virus system. The adenoviral genome introduced into the nucleus of cells as a Trojan Horse, as it were, is now facili- tating investigators to uncover details of cellular mechanisms. In this volume twelve chapters have been collected that summarize important current research on different mechanisms in adenovirus- infected and -transformed cells. It has become increasingly apparent that some of these mechanisms do not only pertain to highly specialized strategies of the viral genome and its expres- sion or replication, but may simultaneously shed light on events indigenous to the cell. "Adenovirus DNA: The Viral Genome and its Expression" high- lights the first publication of the entire annotated sequence of 35. 937 nucleotide pairs of adenovirus type 2 DNA by the Cold Spring Harbor and Uppsala groups (chapter 1). Goran Akusjarvi, Ulf Pettersson (Uppsala University) and Rich Roberts (Cold Spring Harbor) present a survey on the structure and function of the adenovirus-2 genome (chapter 2). A considerable amount of in- formation has been collected on the biochemical mechanisms in- vol ved in adenov irus DNA repl ication in human cells. Al though highly specialized in the way of initiating DNA replication, adenov irus DNA repl ication represents probably one of the best studied systems in work on eukaryotic DNA replication.

Автор: Miguel Chill?n; Assumpci? Bosch
Название: Adenovirus
ISBN: 1627036784 ISBN-13(EAN): 9781627036788
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Описание: Rev. ed. of: Adenovirus methods and protocols / edited by William S.M. Wold, Ann E. Tollefson. 2nd ed. c2007.

Автор: W. Doerfler
Название: The Molecular Biology of Adenoviruses 3
ISBN: 3642695515 ISBN-13(EAN): 9783642695513
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Автор: Harold S. Ginsberg
Название: The Adenoviruses
ISBN: 1468479377 ISBN-13(EAN): 9781468479379
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Автор: W. Doerfler
Название: The Molecular Biology of Adenoviruses 2
ISBN: 3642464963 ISBN-13(EAN): 9783642464966
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Описание: The data summarized in this chapter show that morphological transformation and oncogenesis by adenoviruses are brought about by the coordinated activity of regions E1A and E1B. Gene products of each of these subregions appear to fulfill distinct roles in oncogenic transformation, with the possible exception of the product(s) encoded by the O. 9-kb E1A mRNA. Also unclear is the func- tion of the 20-kd E1B protein, which has a small role, if any, in morphological transformation, but appears to be essential for the development of the oncogenic phenotype, as defined by the ability of transformed cells to grow in immuno- deficient nude mice. The differences in biological properties of oncogenic and nononcogenic adenoviruses must be attributed to differences in the primary structure of the respective E1A and E1B gene products, in particular of the product(s) of the 1. 0-kb E1A mRNA and of the 55-kd protein encoded by the 2. 2-kb EiB mRNA. The availability of cold-sensitive adenovirus mutants has enabled us to conclude that the transformed phenotype is maintained as a result of continuous expression of at least region E1A gene products, and is therefore not the result of a hit-and-run mechanism. Despite the progress in our understanding of adenovirus transformation and oncogenesis, virtually nothing is known about the precise mechanism by which the viral gene products bring about the neoplastic changes in cells. The only exception is the demonstration that Ad12 region E1A (1.

Автор: Walter Doerfler; Petra B?hm
Название: The Molecular Repertoire of Adenoviruses I
ISBN: 364279498X ISBN-13(EAN): 9783642794988
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Описание: For decades this virus system has served - and continues to do so - to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems.

Автор: Walter Doerfler; Petra B?hm
Название: The Molecular Repertoire of Adenoviruses III
ISBN: 3642795889 ISBN-13(EAN): 9783642795886
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Описание: For decades this virus system has served--and continues to do so--to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems.

Автор: W. Doerfler
Название: The Molecular Biology of Adenoviruses I
ISBN: 3642694624 ISBN-13(EAN): 9783642694622
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Описание: A puzzling epidemiological problem was the driving force behind the discovery of human adenoviruses by Wallace Rowe and his colleagues 30 years ago. The potential of adenoviruses as research tools in the molecular and cellular biology of eukaryotic cells was recognized as early as the late 1950s and early 1960s by several investigators.

Автор: Walter Doerfler; Petra B?hm
Название: The Molecular Repertoire of Adenoviruses II
ISBN: 3642795013 ISBN-13(EAN): 9783642795015
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Описание: For decades this virus system has served--and continues to do so--to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems.

Автор: Stephen Misener; Stephen A. Krawetz
Название: Bioinformatics Methods and Protocols
ISBN: 1617371564 ISBN-13(EAN): 9781617371561
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Описание: We divided Bioinformatics Methods and Protocols into five parts, including a thorough survey of the basic sequence analysis software packages that are available at most institutions, as well as the design and implemen- tion of an essential introductory Bioinformatics course.

Автор: William S. M. Wold; Ann E. Tollefson
Название: Adenovirus Methods and Protocols
ISBN: 1617376698 ISBN-13(EAN): 9781617376696
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Описание: This updated book is an essential resource for adenovirus (Ad) researchers beginning in the field, and an inspirational starting point for researchers looking to branch into new areas of Ad study. New chapters address innovative, exciting areas of emphasis in Ad research.