HIV and Dementia, Michael B.A. Oldstone; Ljubisa Vitkovic

Автор: Whalley Lawrence J.
Название: Understanding Brain Aging and Dementia
ISBN: 0231163835 ISBN-13(EAN): 9780231163835
Издательство: Wiley
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Описание: A major new synthesis of the science behind dementia, identifying the genetic factors that contribute to the pace of aging and showing how behaviors starting in childhood can influence how we age.

Автор: Taher Zandi; Richard J. Ham
Название: New Directions in Understanding Dementia and Alzheimer`s Disease
ISBN: 1461279178 ISBN-13(EAN): 9781461279174
Издательство: Springer
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Описание: Proceedings of a conference held in Plattsburgh, New York, May 25--26, 1989

Автор: Markus Tolnay; Alphonse Probst
Название: Neuropathology and Genetics of Dementia
ISBN: 1461354617 ISBN-13(EAN): 9781461354611
Издательство: Springer
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Описание: For more than 35 years the Swiss Society of Neuropathology has organiseditstraditionalInternationalWinterMeeting.Themainaimofthis venue is to bring together neuropathologists and clinicians as well as neuroscientistsinterestedindiseasemechanisms.TheXVIIIthInternational WinterMeeting washeld inMarch 2000 in St. Moritz, Switzerland. The topicofthe2000Meetingwas"NeuropathologyandGeneticsofDementia". Aprogrammeofinvitedplenarylecturesofhigheducationalvalueaswellas platform andposterpresentations given by manyparticipantscoveredthe broadspectrumofdementingdisorders.Encouragedbythehighstandardof the meeting, and probably also influenced by the advent of a new Millenniumwedecided, togetherwithKluwerAcademiclPlenumPublishers, topublishtheProceedingsofthe2000Meetinginthepresentbook. The increaseofthe agedpopulation challenges social and health care systemsinindustrializedsocieties.Maintenanceofhealthandautonomyinto oldage isakeyfactor, andtheautonomyandindependenceofoldpersons crucially depend on mental health. However, neurodegenerative disorders accompanied bydementiaaffect 5-10%ofindividualsoverthe ageof65, and for the age group between 65 and 95 the prevalence of cognitive dysfunction doubles every 5 years. With this challenge in mind, Rossor discusses the clinical syndrome of dementia which encompasses an enormousvarietyofunderlyingdisorders. Over the last few years it has become apparent that many neurodegenerative disorders are characterised by protein misfolding and aberrant polymerization and may therefore be viewed as "aggregation proteopathies". Among them a substantial subsetofdementing disorders, either with or without motor dysfunction, are characterised by abundant v VI Preface neuronaland/orglialaccumulationofhyperphosphorylatedtauprotein.The molecular parametersofthese "tauopathies" are reviewed by Delacourte. Therecentdiscoverythatmutationsofthetaugenearecausativeforfamilial formsoffrontotemporaldementiaandParkinsonism(FTDP-17)broughtthe "taupathway"and the"tauopathies"tothecentrestage.Thisextraordinary breakthroughwillbecoveredbySpillantiniandGoedert.Thereisincreasing evidence that argyrophilic grain disease is much more frequent in older patients than previously thought. Tolnay et al. are reviewing recent contributionstothepathologyofthislate-onsetdementingdisorderinwhich ofamyloidbetadeposits, isalmost taupathology, inthealmosttotalabsence exclusivelyrestricted to the limbic lobe and the amygdala. Schultzet al. report an intriguing age-related progression of neuronal and glial tau pathologyinbaboonsthusrenderingthe baboonapotentialprimatemodel forage-relatedhuman"tauopathies". Gotzetal. introducetransgenicmice expressingmutated human tau as valuable animal models for reproducing formationofneuro-andglialfibrillarylesions.

Автор: Chikako Tanaka; Patrick L. McGeer; Yasuo Ihara
Название: Neuroscientific Basis of Dementia
ISBN: 3034894821 ISBN-13(EAN): 9783034894821
Издательство: Springer
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Описание: In step with our growing lifespan, dementia is becoming a widespread handicap to the health and well-being of individuals and a burden on human society world-wide.

Автор: Seggane Musisi; Stanley Jacobson
Название: Brain Degeneration and Dementia in Sub-Saharan Africa
ISBN: 1493924559 ISBN-13(EAN): 9781493924554
Издательство: Springer
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Описание: Stemming from a 2012 conference entitled Brain Degenerations and Emerging Mental Health Challenges in Sub-Saharan Africa, this book is aimed at both the general practitioner interested in CNS disorders, and the specialist who would like to know more about CNS pathology in Africa. By employing a broad defi nition of what brain degeneration means, the authors are able to touch upon everything from dementias and CNS malignancy to traumatic brain injury and CNS infective processes. This book draws from and builds upon the original conference presentations, and incorporates the most up-to-date science behind brain degeneration as well as actual case reports. Each of the book’s six sections off er the reader a deeper understanding of brain degeneration as it exists in Sub-Saharan Africa.

Автор: Gary Landsberg; Alad?r Ma?ari; Norbert ?ilka
Название: Canine and Feline Dementia
ISBN: 3319532189 ISBN-13(EAN): 9783319532189
Издательство: Springer
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Описание: The book deeply focuses on the epidemiology, diagnostics, therapy and molecular basis of canine and feline dementia or cognitive dysfunction syndrome. In the first three chapters we describe the clinical pictures of canine and feline dementia, discuss the medical causes of the disease and its phenotypic variability.

Автор: Peter Paul De Deyn; Debby Van Dam
Название: Animal Models of Dementia
ISBN: 1493961187 ISBN-13(EAN): 9781493961184
Издательство: Springer
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Описание: With an ever-increasing elderly population and the resultant rising levels of dementia-related disorders, preclinical research based on animal models is pivotal to our knowledge of underlying molecular mechanisms and drug discovery aiming at the development of therapeutic strategies alleviating or preventing the neurological devastation. In Animal Models of Dementia, expert researchers provide contributions that stress the importance of extensively validated animal models in drug discovery and development in order to predict clinical activity. Beginning with general aspects of animal modeling, related ethical issues, and essential methodological considerations, the highly detailed volume then continues with various levels of model validation, including pathological, behavioral, neurochemical, pharmacological, and imaging aspects, followed by sections focused on specific disorders, such as Alzheimer’s disease, Parkinson’s disease, metachromatic leukodystrophy and adrenoleukodystrophy, amyotrophic lateral sclerosis, frontotemporal dementia as well as vascular dementia and more. As a volume in the renowned Neuromethods series, this book offers a detailed, yet accessible, overview of currently available animal models in the field of dementia research, and touches, as well, upon more general areas linked to the development and use of animal models. Comprehensive and efficient, Animal Models of Dementia will significantly aid both experienced animal researchers as well as investigators on the verge of beginning animal model-based dementia research.

Автор: Siegfried Hoyer; Dorothea M?ller; Konstanze Plasch
Название: Cell and Animal Models in Aging and Dementia Research
ISBN: 3211825495 ISBN-13(EAN): 9783211825495
Издательство: Springer
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Описание: In this supplement, different approaches are dealt with how to induce structural and/or metabolic abnormalities in relevant cell cultures, in brain slices and in experimental animals, and how behavioral changes parallel the metabolic variations.

Автор: Susan E. Daniel; Felix F. Cruz-Sanchez; Andrew J.
Название: Dementia in Parkinsonism
ISBN: 3211829598 ISBN-13(EAN): 9783211829592
Издательство: Springer
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Описание: Recent studies suggest that pathology of Parkin- son`s disease now ranks second to Alzheimer`s disease as the commonest sub- strate of dementia in elderly patients. : The language of the basal ganglia . . . . . . . . . . . . . . . . . . . . . .

Автор: Kurt Jellinger; Reinhold Schmidt; Manfred Windisch
Название: Ageing and Dementia
ISBN: 3211837965 ISBN-13(EAN): 9783211837962
Издательство: Springer
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Описание: Includes the papers that were presented at the 7th International Symposium in Graz, September 2001, and gives an overview of the various concepts of pathogenesis, diagnosis, and treatment strategies of pathological brain ageing and dementias, early recognition of mild cognitive impairment and the possibilities of prevention of dementing processes.

Автор: Vijaya L. Melnick; Nancy N. Dubler
Название: Alzheimer`s Dementia
ISBN: 1461295971 ISBN-13(EAN): 9781461295976
Издательство: Springer
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Описание: Clearly older people must be protected from in- appropriate research and careful attention must be paid to the circumstances under which research is conducted on those older persons who have given anything less than full consent.

Автор: Alexander Hartmann; Wolfgang Kuschinsky; Siegfried
Название: Cerebral Ischemia and Dementia
ISBN: 3642762107 ISBN-13(EAN): 9783642762109
Издательство: Springer
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Описание: All aspects of dementia after cerebral ischemia are discussed in this book in detail, in contrast to other sources which usually only discuss general aspects.