Cell Receptors, Gerhard Seifert; U. Beisiegel; F. Buck; G.V. Child
Автор: Anton G. Kutikhin; Arseniy E. Yuzhalin Название: Genomics of Pattern Recognition Receptors ISBN: 3034807945 ISBN-13(EAN): 9783034807944 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book details the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, coverage examines the structure and function of Toll-like and NOD-like receptors.
Автор: Allison D. Fryer; Arthur Christopoulos; Neil M. Na Название: Muscarinic Receptors ISBN: 3642446981 ISBN-13(EAN): 9783642446986 Издательство: Springer Рейтинг: Цена: 65545.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Felix J. Kim; Gavril W. Pasternak Название: Sigma Proteins: Evolution of the Concept of Sigma Receptors ISBN: 3319658514 ISBN-13(EAN): 9783319658513 Издательство: Springer Рейтинг: Цена: 39130.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Two sigma receptor subtypes have been proposed, sigma1 and 2. Largely based on traditional pharmacologic approaches, the Sigma1 protein has been associated with a broad range of signaling systems, including G-protein coupled receptors, NMDA receptors, and ion channels.
Автор: Constance N. Wilson; S. Jamal Mustafa Название: Adenosine Receptors in Health and Disease ISBN: 3662501627 ISBN-13(EAN): 9783662501627 Издательство: Springer Рейтинг: Цена: 65305.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Adenosine receptors are important novel molecular targets in disease and drug discovery. As a result of investigations into these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials.
Автор: Marta Filizola Название: G Protein-Coupled Receptors - Modeling and Simulation ISBN: 9402402586 ISBN-13(EAN): 9789402402582 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses.
Описание: This book presents the latest methods and technology used to characterize and discover novel mechanisms of G protein-coupled receptors (GPCRs) which, in many cases, can be used directly to design experiments for the reader`s particular GPCR of interest.
Forward, Mary Ann Asson-Batres and Cecile Rochette-Egly
1 History of Retinoic Acid Receptors Doris M. Benbrook, Pierre Chambon, Cecile Rochette-Egly, and Mary Ann Asson-Batres 2 Architecture of DNA Bound RAR Heterodimers Natacha Rochel and Dino Moras 3 Retinoic Acid Receptors: Structural Basis for Coregulator Interaction and Exchange Albane le Maire and William Bourguet 4 Evolution of Retinoic Acid Receptors and Retinoic Acid Signaling Juliana Gutierrez-Mazariegos, Michael Schubert and Vincent Laudet 5 RXRs: Collegial Partners Federica Gilardi and Bйatrice Desvergne 6 Nuclear and Extra-Nuclear Effects of Retinoic Acid Receptors: How they are interconnected Aleksandr Piskunov, Ziad Al Tanoury, and Cйcile Rochette-Egly 7 The Roles of Retinoic Acid and Retinoic Acid Receptors in Inducing Epigenetic Changes Alison Urvalek, Kristian Laursen, and Lorraine J. Gudas 8 RARs and microRNAs Clara Nervi and Francesco Grignani 9 Integrative genomics to dissect retinoids functions Marco-Antonio Mendoza-Parra and Hinrich Gronemeyer 10 Complexity of the RAR‐Mediated Transcriptional Regulatory Programs Zhijie Liu, Qidong Hu and Michael G. Rosenfeld Index.
Автор: Kathleen M. Eyster Название: Estrogen Receptors ISBN: 1493931261 ISBN-13(EAN): 9781493931262 Издательство: Springer Рейтинг: Цена: 17468.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This volume examines a wide array of vital technologies for advancing our understanding of the receptor-mediated actions of estrogen. The protocols in this book range from standard methods and vital laboratory workhorses, such as receptor binding assays and western blot, to newer technologies such as RNAseq and proximity ligation assay. Chapters also discuss protocols from a broad range of tissue types to demonstrate the variety of estrogen receptor effects. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and thorough, Estrogen Receptors: Methods and Protocols is a detailed and helpful resource for scientists who are intrigued by the many facets of estrogen.
The chapter 'Bioinformatics Analysis of Estrogen-Responsive Genes' is open access under a CC BY 4.0 license.
Автор: Iain J. McEwan; Raj Kumar Название: Nuclear Receptors: From Structure to the Clinic ISBN: 3319371282 ISBN-13(EAN): 9783319371283 Издательство: Springer Рейтинг: Цена: 16977.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. It brings together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity.
The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors.
Автор: Chiquito J. Crasto Название: Olfactory Receptors ISBN: 1493962027 ISBN-13(EAN): 9781493962020 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Methods in Molecular Biology (TM) book covers knowledge dissemination and theoretical assessment of OR structure and function, plus development and use of expression systems and experimental functional analysis. Offers reproducible protocols, tips and more.
Автор: Roger D. Cone Название: The Melanocortin Receptors ISBN: 1617370827 ISBN-13(EAN): 9781617370823 Издательство: Springer Рейтинг: Цена: 34799.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Roger Cone and a distinguished team of expert investigators provide the first major treatment of this critically important receptor family. Topics include the characterization of the melanocortin receptors, the biochemical mechanism of receptor action, and receptor function and regulation.
Автор: C. Marescaux; M. Vergnes; R. Bernasconi Название: Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors ISBN: 3211823409 ISBN-13(EAN): 9783211823408 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Generalized non convulsive epilepsy (GNCE), also called absence or petit mal epilepsy, is a disease appearing during childhood. This supplementum provides an original multidisciplinary approach to the mechanisms involved in GNCE and demonstrates that rodent models are a promising tool which complements the classical feline penicillin model.
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