The Antibody Enigma, Thomas Kindt

Автор: Mohamed Al-Rubeai
Название: Antibody Expression and Production
ISBN: 9400736134 ISBN-13(EAN): 9789400736139
Издательство: Springer
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Цена: 28732.00 р.
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Описание: This book covers generation, optimization, characterization, production and applications of antibodies, offering theoretical background and describing methods for expression of antibody in microbial and animal cell cultures and transgenic animals and plants.

Автор: Proetzel
Название: Antibody Methods and Protocols
ISBN: 1617799300 ISBN-13(EAN): 9781617799303
Издательство: Springer
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Цена: 20962.00 р.
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Описание: The rapidly growing field of antibody research is the result of many advancing technologies allowing current developments to take advantage of molecular engineering to create tailor-made antibodies.  Antibody Methods and Protocols attempts to provide insight into the generation of antibodies using in vitro and in vivo approaches, as well as technical aspects for screening, analysis, and modification of antibodies and antibody fragments.  The detailed volume is focused on basic protocols for isolating antibodies and, at the same time, it selects a range of specific areas with the aim of providing guides for the overall process of antibody isolation and characterization as well as protocols for enhancing classical antibodies and antibody fragments.  Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Antibody Methods and Protocols provides a broad and useful background to support ongoing efforts by novices and experts alike and encourages the development of new imaginative approaches to this vital area of study.

Автор: Robert Aitken (Ed.)
Название: Antibody Phage Display
ISBN: 1603273018 ISBN-13(EAN): 9781603273015
Издательство: Springer
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Цена: 22359.00 р.
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Описание: Phage display technology has revolutionized approaches to the analysis of biomedical problems, impacting the fields of immunology, cell biology, biotechnology, pharmacology, and drug discovery. This title provides a resource that guides readers in the design and execution of experiments based around antibody phage display.

Автор: Brandon DeKosky
Название: Decoding the Antibody Repertoire
ISBN: 3319585177 ISBN-13(EAN): 9783319585178
Издательство: Springer
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Цена: 19564.00 р.
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Описание:

This thesis outlines the development of the very first technology for high-throughput analysis of paired heavy and light-chain antibody sequences, opening an entirely new window for antibody discovery and the investigation of adaptive immune responses to vaccines and diseases.

Previous methods for high-throughput immune repertoire sequencing have been unable to provide information on the identity of immune receptor pairs encoded by individual B or T lymphocytes. The author directly addresses these limitations by designing two new technologies for sequencing multiple mRNA transcripts from up to 10 million isolated, single cells.

The techniques developed in this work have enabled comprehensive interrogation of human B-cell repertoires and have been applied for rapid discovery of new human antibodies, to gain new insights into the development of human antibody repertoires, and for analysis of human immune responses to vaccination and disease.

Автор: Ulf Grawunder; Stefan Barth
Название: Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins
ISBN: 3319468758 ISBN-13(EAN): 9783319468754
Издательство: Springer
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Цена: 20962.00 р.
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This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities.

The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.

Автор: Falk Nimmerjahn
Название: Molecular and Cellular Mechanisms of Antibody Activity
ISBN: 1461471060 ISBN-13(EAN): 9781461471066
Издательство: Springer
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Цена: 23757.00 р.
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Описание: Recent years have seen an exponential growth in knowledge about the molecular and cellular mechanisms of antibody activity. This book examines how these new results have dramatically changed our view of how antibodies function in vivo.

Автор: Roland E. Kontermann; Stefan D?bel
Название: Antibody Engineering Volume 2
ISBN: 3642011462 ISBN-13(EAN): 9783642011467
Издательство: Springer
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Цена: 32142.00 р.
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Описание: This book is a toolbox of well-established basics and many exciting new techniques in antibody engineering, reflecting the latest hands-on work of key laboratories in this fast-moving field. The new edition is expanded to nearly double the number of protocols.

Автор: Roland E. Kontermann; Stefan D?bel
Название: Antibody Engineering Volume 1
ISBN: 3642011438 ISBN-13(EAN): 9783642011436
Издательство: Springer
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Цена: 41925.00 р.
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Описание: This book is a toolbox of well-established basics and many exciting new techniques in antibody engineering, reflecting the latest hands-on work of key laboratories in this fast-moving field. The new edition is expanded to nearly double the number of protocols.

Автор: Borrebaeck, Carl A. K.
Название: Antibody Engineering
ISBN: 0195091507 ISBN-13(EAN): 9780195091502
Издательство: Oxford Academ
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Цена: 13306.00 р.
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Описание: This text has been designed to help researchers understand and develop designer antibodies. Its practical approach makes use of state-of-the-art technologies for the production of recombinant human or mouse monoclonal antibodies.