Copper Transport and Its Disorders, Arturo Leone; Julian F.B. Mercer

Автор: Martin Beckerman
Название: Fundamentals of Neurodegeneration and Protein Misfolding Disorders
ISBN: 3319342843 ISBN-13(EAN): 9783319342849
Издательство: Springer
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Описание: Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer`s disease and Parkinson`s disease to Huntington`s disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration.

Автор: Lina K. Blusch
Название: The Siamese-Twin Porphyrin and Its Copper and Nickel Complexes: A Non-Innocent Twist
ISBN: 3319343653 ISBN-13(EAN): 9783319343655
Издательство: Springer
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Описание: This thesis describes the first successful synthesis of a new pyrazole-expanded porphyrin. The `Siamese-Twin Porphyrin` provides two conjoined porphyrin-like coordination spheres, which can thus accommodate two metal ions within the same ligand.

Автор: Arturo Leone; Julian F.B. Mercer
Название: Copper Transport and Its Disorders
ISBN: 0306460459 ISBN-13(EAN): 9780306460456
Издательство: Springer
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Цена: 30606.00 р.
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Описание: Covers the molecular and cellular biology of copper transport, with an emphasis on copper based diseases, especially the genetic disorder Menkes disease.

Автор: Beckerman, Martin
Название: Fundamentals of neurodegeneration and protein misfolding disorders
ISBN: 3319221167 ISBN-13(EAN): 9783319221168
Издательство: Springer
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Цена: 16769.00 р.
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Описание: This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer’s disease and Parkinson’s disease to Huntington’s disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today’s forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.

Автор: Carol A. Wise; Jonathan J. Rios
Название: Molecular Genetics of Pediatric Orthopaedic Disorders
ISBN: 1493946102 ISBN-13(EAN): 9781493946105
Издательство: Springer
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Цена: 16977.00 р.
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Описание: Simultaneously, the study of pediatric orthopaedic disorders has been continuously refined and updated, highlighting a number of likely genetic conditions that are as yet unsolved.Molecular Genetics of Pediatric Orthopaedic Disorders updates researchers and clinicians of new developments of pediatric orthopaedic genetics.

Автор: Reinhard Kr?mer; Christine Ziegler
Название: Membrane Transport Mechanism
ISBN: 3662523051 ISBN-13(EAN): 9783662523056
Издательство: Springer
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Цена: 19589.00 р.
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Описание: This book provides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The unifying mechanism of energized solute transport across membranes is assumed to consist of the conformational cycling of a carrier protein to provide access to substrate binding sites from either side of a cellular membrane.

Автор: Koenen Sandro
Название: Life Course Approach to Mental Disorders
ISBN: 0199657017 ISBN-13(EAN): 9780199657018
Издательство: Oxford Academ
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Цена: 9346.00 р.
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Описание: A Life Course Approach to Mental Disorders examines the causes and consequences of a wide-range of mental disorders throughout life, from the peri-natal period through old age.

Автор: Fredric P. Manfredsson
Название: Gene Therapy for Neurological Disorders
ISBN: 1493948962 ISBN-13(EAN): 9781493948963
Издательство: Springer
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Цена: 19564.00 р.
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Описание:

Part I Introduction

1. Introduction to Viral Vectors and Other Delivery Methods for Gene Therapy of the Nervous System
Frederic P. Manfredsson

Part II Expression Cassettes

2. Delivering Transgenic DNA Exceeding the Carrying Capacity of AAV Vectors
Matthew L. Hirsch, Sonya J. Wolfe, and R. J. Samulski

3. Expression of Multiple Functional RNAs or Proteins from One Viral Vector
Tomas Bjцrklund

4. Regulated Gene Therapy
Ludivine Breger, Erika Elgstrand Wettergren, Luis Quintino, and Cecilia Lundberg

5. Design of shRNA and miRNA for Delivery to the CNS
Gabriela Toro and Christian Mueller

6. Tissue Specific Promoters in the CNS
Sebastian Kьgler

Part III Viral Vector Production

7. Small Scale Recombinant Adeno-Associated Virus Purification
Corinna Burger and Kevin Nash

8. Lentivirus Production and Purification
Matthew J. Benskey and Frederic P. Manfredsson

9. Viral Vector Production: Adenovirus
Julius W. Kim, Ramin A. Morshed, J. Robert Kane, Brenda Auffinger, Jian Qiao, and Maciej S. Lesniak

Part IV Viral Vector Tropism

10. Controlling AAV Tropism in the Nervous System with Natural and Engineered Capsids
Michael J. Castle, Heikki T. Turunen, Luk H. Vandenberghe, and John H. Wolfe

11. Altering Tropism of rAAV by Directed Evolution
Damien Marsic and Sergei Zolotukhin

12. Altering Entry Site Preference of Lentiviral Vectors into Neuronal Cells by Pseudotyping with Envelope Glycoproteins
Kenta Kobayashi, Shigeki Kato, Ken0ichi Inoue, Masahiko Takada, and Kazuto Kobayashi

13. Directed Evolution of Adenoviruses
Jason G. Smith

Part V Delivery Methods

14. Intraparenchymal Stereotaxic Delivery of rAAV and Special Considerations in Vector Handling
Matthew J. Benskey and Frederic P. Manfredsson

15. MRI-Guided Delivery of Viral Vectors
Ernesto A. Salegio, John Bringas, Krystof S. Bankiewicz

16. Systemic Gene Therapy for Targeting the CNS
Sara E. Gombash and Kevin D. Foust

17. Widespread Neuronal Transduction of the Rodent CNS via Neonatal Viral Injection
Ji-Yoen Kim, Stacy D. Grunke, and Joanna L. Jankowsky

18. AAV-Mediated Gene Transfer to Dorsal Root Ganglion
Hongwei Yu, Gregory Fischer, and Quinn H. Hogan

19. Gene Therapy of the Peripheral Nervous System: The Enteric Nervous System
Matthew J. Benskey and Frederic P. Manfredsson

20. Gene Therapy of the Peripheral Nervous System: Celiac Ganglia

21. Convection Enhanced Delivery of Recombinant Adeno-Associated Virus into the Mouse Brain
Kevin R. Nash and Marcia N. Gordon

22. Non-Viral Gene Therapy of the Nervous System: Electroporation
XueFeng Ding and Ming Fan

23. Non-Viral, Lipid-Mediated DNA and mRNA Gene Therapy of the Central Nervous System (CNS): Chemical-Based Transfection
James G. Hecker

24. Ex Vivo Gene Therapy Using Human Mesenchymal Stem Cells to Deliver Growth Factors in the Skeletal Muscle of a Familial ALS Rat Model
Masatoshi Suzuki and Clive N. Svendsen

Part VI Gene-Therapy Based Modeling of Neurodegenerative Disorders

25. Gene Therapy Models of Alzheimer's Disease and Other Dementias
Benjamin Combs, Andrew Kneynsberg, and Nicholas M. Kanaan

26. Viral Vector-Based Modeling of Neurodegenerative Disorders: Parkinson's Disease
D. Luke Fischer, Sara E. Gombash, Christopher J. Kemp, Frederic P. Manfredsson, Nicole K. Polinski, Megan F. Duffy, and Caryl E. Sortwell

27. Gene Therapy-Based Modeling of Neurodegenerative Disorders: Huntington's Disease
Deborah Young

Part VII Gene-Therapy for the Treatment of Neurological Disorders

28. Gen

Автор: David Maguire; Duane F. Bruley
Название: Oxygen Transport to Tissue XXVIII
ISBN: 1489978992 ISBN-13(EAN): 9781489978998
Издательство: Springer
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Цена: 23757.00 р.
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Описание: At the beginning of a Southern Hemisphere Autumn, the ISOTT tribe assembled for its annual corroboree on the banks of the Brisbane River in Australia for five days of exciting science. Some of the tribe had travelled from as far as Sweden and other parts of Europe; many had spirited themselves across the Pacific Ocean from the Americas. Yet another small contingent had paddled down from Japan. All came with message sticks from their camp-sites. The conference opened with an outdoor barbecue at the Southbank precinct, with the stars of the Southern Cross painting the river on one side and the artificial beach on the other; a perfect venue to meet old friends and to welcome new ones as a cool breeze wafted over our fires. For the next five days there was the usual focus on oxygen; measurement techniques, its role in cancer and other diseases that beset us mortals and the biochemistry and physiology of this small vital molecule. It still astounds many that we have not yet learnt everything there is to know about this valuable friend, albeit a dangerous foe. Time was found for us to visit Australia Zoo and stand in awe before exhibits of Australia’s wild-life; great vicious creatures unchanged from the age of the dinosaurs, poisonous snakes and spiders, and gentle marsupials that posed for our digital cameras.

Автор: Martino Ruggieri; Ignacio Pascual Castroviejo; Con
Название: Neurocutaneous Disorders
ISBN: 3709119073 ISBN-13(EAN): 9783709119075
Издательство: Springer
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Цена: 40389.00 р.
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Описание: Neurocutaneous diseases are a wide group of conditions that affect the nervous system but appear as lesions of the skin. Some of the more common entities have variable forms of expression that can confuse the diagnosis; for the rare conditions it is difficult to find descriptions in the literature. Recent insights into their cellular, biochemical and molecular genetic bases have shown the essential need for a new nosology and updated genotype-phenotype correlations. The book provides an authoritative source of knowledge about these difficult problems and bridges the gap between clinical recognition and the new molecular medicine. The editors, distinguished clinicians and geneticists, assembled an internationally renowned group of collaborators, many of them the experts who first described a particular disorder or established its present accepted definition. They have written a practical, comprehensive guide to the recognition, investigation and management of more than 60 recognised phakomatoses.

Автор: Nayab Batool Rizvi; Saeed Ahmad Nagra
Название: Minerals and Lipids Profiles in Cardiovascular Disorders in South Asia
ISBN: 3662511282 ISBN-13(EAN): 9783662511282
Издательство: Springer
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Цена: 13059.00 р.
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Описание: This book correlates different minerals and lipids serum profiles with the prevalence of cardiovascular disorders in South Asian countries, focusing on Pakistan. The data presented will help promote understanding and more effective solutions to the problem.

Автор: Janusz K. Rybakowski; Alessandro Serretti
Название: Genetic Influences on Response to Drug Treatment for Major Psychiatric Disorders
ISBN: 3319270389 ISBN-13(EAN): 9783319270388
Издательство: Springer
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Цена: 10480.00 р.
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Описание: Written by global experts, this book provides a modern comprehensive insight into the pharmacogenetics of treatment of major psychoses: schizophrenia, bipolar disorder and depression.