Biological Reactive Intermediates Vi, Patrick M. Dansette; Robert R. Snyder; Terrence J.

Автор: P. Traub
Название: Intermediate Filaments
ISBN: 3642702325 ISBN-13(EAN): 9783642702327
Издательство: Springer
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Описание: The investigation of cultured cells and of tissues from various developmental stages has furnished a host of information on the inter-and intracellular distribution of the different types of intermediate filaments and led to the contention that they have a structural and organizing function in the cytoplasm of vertebrate cells.

Автор: David Jollow
Название: Biological Reactive Intermediates
ISBN: 1461341264 ISBN-13(EAN): 9781461341260
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Описание: Thus it seems appropriate to collect in one volume a series of reports outlining advances in the study of the formation of chemically active intermediary metabolic products of chemicals, mechanisms of toxicity or carcinogenesis, and pathways for true detoxication of these chemicals.

Автор: Robert Snyder
Название: Biological Reactive Intermediates—II
ISBN: 1475706766 ISBN-13(EAN): 9781475706765
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Автор: Robert R. Snyder; James J. Kocsis; I. Glenn Sipes;
Название: Biological Reactive Intermediates V
ISBN: 0306451972 ISBN-13(EAN): 9780306451973
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Описание: Proceedings of the Fifth International Symposium held in Munich, Germany, January 4-8, 1995.

Автор: Patrick M. Dansette; Robert R. Snyder; Terrence J.
Название: Biological Reactive Intermediates Vi
ISBN: 0306466597 ISBN-13(EAN): 9780306466595
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Описание: Presents a discussion of the biological effects produced following the metabolism of xenobiotic chemicals to chemically reactive metabolites. This volume covers structure-activity relationships, advances in the chemistry of reactive metabolites, and the generation and activity of reactive oxygen species with special emphasis on nitric oxide.

Автор: Charlotte M. Witmer; Robert R. Snyder; David J. Jo
Название: Biological Reactive Intermediates IV
ISBN: 1468458795 ISBN-13(EAN): 9781468458794
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Описание: Proceedings of the Fourth International Symposium, held in Tucson, Arizona, January 14--17, 1990

Автор: Robert R. Snyder; James J. Kocsis; I. Glenn Sipes;
Название: Biological Reactive Intermediates V
ISBN: 1475794827 ISBN-13(EAN): 9781475794823
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Описание: Proceedings of the Fifth International Symposium held in Munich, Germany, January 4-8, 1995.

Автор: James J. Kocsis; David J. Jollow; Charlotte M. Wit
Название: Biological Reactive Intermediates III
ISBN: 1468451367 ISBN-13(EAN): 9781468451368
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Описание: This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapid growth of mechanistic toxicology over the last decade. These conferences were initially stimulated by the attempt to uncover the significance behind the observations that the toxicity of carcinogenic responses produced by many chemicals was associated with the observation that their metabolism led to the formation of chemcially reactive electrophiles which covalently bound to nucleophilic sites in cells such as proteins, nucleic acid or fats. Recently, newer concepts have arisen which have necessitated the expansion of subjects covered by the conference. For example, the application of newer knowledge of the role of active oxygen species in reactive metabolite formation, the concept of suicide substrates, examination of the function of glutathione in cells, application of immunological techniques and molecular biological probes to the solution of toxicological problems all had an impact on the study of the biological reactive intermediates.

Автор: R.D. Goldman; P.M. Steinert
Название: Cellular and Molecular Biology of Intermediate Filaments
ISBN: 1475796064 ISBN-13(EAN): 9781475796063
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Автор: R.D. Goldman; P.M. Steinert
Название: Cellular and Molecular Biology of Intermediate Filaments
ISBN: 0306433176 ISBN-13(EAN): 9780306433177
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Описание: Research activity on intermediate filaments (IF) has increased dramatically over the past decade. For the most part, this surge of interest is due to their identification as ubiquitous constituents of the cytoskeleton and karyoskeleton (nuclear matrix) of eukaryotic cells and the fact that we know very little regarding their functions. In sharp contrast to the other major cytoskeletal systems, microfilaments and microtubules, IF exhibit a high degree of heterogeneity with regard to their protein subunit composition. Indeed, one can only marvel at the number of different IF polypeptides, their associated proteins (IFAP) and, consequently, the number of genes involved in encoding the multiple constituents of the various IF networks found in different cell types. The chapters in this book demonstrate how various experimental approaches involv- ing cellular, molecular, biochemical, and immunological methods have been utilized to generate information regarding the structure and function of IF. To this end, we have gathered together chapters from experts in the major fields of IF research. In each chapter, the authors have combined reviews of the available scientific literature with their own ideas on current and future directions for IF research. The chapters have been divided into five major sections which are concerned with the subcellular organization of IF, the molecular structure of IF, the differential expression of IF genes, descriptions of associ- ated proteins involved in the intracellular organization of IF, and finally an analysis of the changes seen in IF in pathological conditions.

Автор: Harald Herrmann; J. Robin Harris
Название: Intermediate Filaments
ISBN: 0306458543 ISBN-13(EAN): 9780306458545
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Описание: This text looks at subcellular chemistry, particularly at intermediate filaments. Topics include fish intermediate filament proteins in structure, evolution, and function, and lessons from keratin transgenic and knockout mice.

Автор: Katherine L. Wilson
Название: Intermediate Filament Associated Proteins,569
ISBN: 0128034696 ISBN-13(EAN): 9780128034699
Издательство: Elsevier Science
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Описание: Intermediate Filament Associated Proteins, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in intermediate filament associated proteins and contains sections on such topics as lamin-associated proteins, intermediate filament-associated proteins and plakin, and other cytoskeletal cross-linkers.