James J. Kocsis; David J. Jollow; Charlotte M. Wit Biological Reactive Intermediates III 9781468451368

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Автор: James J. Kocsis; David J. Jollow; Charlotte M. Wit
Название: Biological Reactive Intermediates III
ISBN: 9781468451368
Издательство: Springer
Классификация:

Эндокринология

Биохимия

ISBN-10: 1468451367
Обложка/Формат: Paperback
Страницы: 1059
Вес: 1.83 кг.
Дата издания: 01.09.2013
Серия: Advances in Experimental Medicine and Biology
Язык: English
Издание: Softcover reprint of
Иллюстрации: Xv, 1059 p.
Размер: 254 x 178 x 54
Читательская аудитория: Professional & vocational
Основная тема: Life Sciences
Подзаголовок: Mechanisms of Action in Animal Models and Human Disease
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapid growth of mechanistic toxicology over the last decade. These conferences were initially stimulated by the attempt to uncover the significance behind the observations that the toxicity of carcinogenic responses produced by many chemicals was associated with the observation that their metabolism led to the formation of chemcially reactive electrophiles which covalently bound to nucleophilic sites in cells such as proteins, nucleic acid or fats. Recently, newer concepts have arisen which have necessitated the expansion of subjects covered by the conference. For example, the application of newer knowledge of the role of active oxygen species in reactive metabolite formation, the concept of suicide substrates, examination of the function of glutathione in cells, application of immunological techniques and molecular biological probes to the solution of toxicological problems all had an impact on the study of the biological reactive intermediates.
Дополнительное описание: Years with Elizabeth and James Miller: In Appreciation.- I. Chemistry and Biology of Biological Reactive Intermediates.- II. Biology of Cytochrome P-450 and Related Aspects of the Mixed Function Oxidase.- III. Suicide Substrates of Cytochrome P-450.- IV.

Biological Reactive Intermediates III, James J. Kocsis; David J. Jollow; Charlotte M. Wit