Описание: The definition of "photonics" has been broadened in recent years to include nonlinear and quantum optics, today usually based on laser light. This book covers the fundamental properties of photon and light beams, both experimentally and theoretically. It covers the essentials of linear interactions and most of the nonlinear interactions between light and matter in both the transparent and absorbing cases. It also provides a basic knowledge of modern lasers, as well as the principles of nonlinear optical spectroscopy. It is self-consistent and enriched by a large number of calculated illustrations, examples, and descriptive tables. Graduate students in physics and electrical engineering, as well as other sciences, will find this book a thorough introduction to the field, while for lecturers and scientists it offers a rich source of useful information and a ready-to-hand reference. About 4000 references open access to original literature.The second edition is completely revised and enlarged.
Автор: Alexander E. Knight Название: Single Molecule Biology, ISBN: 0123742277 ISBN-13(EAN): 9780123742278 Издательство: Elsevier Science Рейтинг: Цена: 11789.00 р. Наличие на складе: Поставка под заказ.
Описание: Describes such single molecule techniques (that allow for manipulation and measurement of single biological molecules within a live cell) as single molecule fluorescence, optical tweezers, and scanning probe microscopy. This book is organized by biological system or molecule. It discusses applications in molecular diagnostics and drug discovery.
Описание: Inthis thesis single-molecule fluorescence resonance energy transfer(FRET)spectroscopy was used to study the folding of a protein that belongsto the large and important family of repeat proteins.
Автор: Sylvain Celanire; Sonia Poli Название: Small Molecule Therapeutics for Schizophrenia ISBN: 3319115014 ISBN-13(EAN): 9783319115016 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Antipsychotics and the Dopamine-Serotonin Connection.- GLYT1 Inhibitors: From Hits to Clinical Candidates.- Metabotropic Glutamate Receptor 2 Activators.- Activation of the mGlu5 Receptor for the Treatment of Schizophrenia and Cognitive-Deficit-Associated Disorders.- Muscarinic Acetylcholine Receptor Activators.- Nicotinic Acetylcholine Receptor Modulators.- The Use of PDE10A and PDE9 Inhibitors for Treating Schizophrenia.
Автор: Mahesh Uttamchandani; Shao Q. Yao Название: Small Molecule Microarrays ISBN: 1493958151 ISBN-13(EAN): 9781493958153 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Small molecule microarrays (SMM) were introduced just a decade ago in 1999 and, within a short space of time, have already established themselves as a vibrant, next generation platform for high-throughput screening. Small Molecule Microarrays: Methods and Protocols showcases a collection of contributions guiding researchers toward ways in which small molecule microarray technology may be deployed for multiplexed screening and profiling. Organized by the categories of small molecules presented on the microarrays, this detailed volume describes in-depth techniques for chemical libraries, peptide libraries, and carbohydrate microarrays. Written in the highly successful Methods in Molecular Biology™ series, chapters contain brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, vital tips on troubleshooting this often difficult technology, and advice on avoiding known pitfalls. Authoritative and cutting-edge, Small Molecule Microarrays: Methods and Protocols provides meticulous depictions of key hands-on experience and seeks to inspire a future generation of microarray practitioners to take this significant technology forward.
Описание: This book highlights the current state-of-the-art regarding the application of applied crystallographic methodologies for understanding, predicting and controlling the transformation from the molecular to crystalline state with the latter exhibiting pre-defined properties.
Автор: Andres F. Oberhauser Название: Single-molecule Studies of Proteins ISBN: 1489991123 ISBN-13(EAN): 9781489991126 Издательство: Springer Рейтинг: Цена: 22201.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book examines the successful application of single-molecule techniques to a wide range of biological events. It explores sophisticated advances in powerful new analytical, computational, and imaging methods.
Автор: Erwin J. G. Peterman Название: Single Molecule Analysis ISBN: 1493972707 ISBN-13(EAN): 9781493972708 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Part I
1. Introduction to Optical Tweezers: Background, System Designs, and Commercial Solutions Joost van Mameren, Gijs J. L. Wuite, and Iddo Heller
2. RNA Unzipping and Force Measurements with a Dual Optical Trap Laurent Geffroy, Pierre Mangeol, Thierry Bizebard, and Ulrich Bockelmann
3. Protein Tethering for Folding Studies Fatemeh Moayed, Roeland J. van Wijk, David P. Minde, and Sander J. Tans
4. Combining Structure-Function and Single-Molecule Studies on Cytoplasmic Dynein Lu Rao, Maren Hьlsemann, and Arne Gennerich
5. A Brief Introduction to Single-Molecule Fluorescence Methods Siet M. J. L. van den Wildenberg, Bram Prevo, and Erwin J. G. Peterman
PART II
6. Fluorescent Labeling of Proteins Mauro Modesti
7. Single-Molecule Imaging of Escherichia coli Trans-Membrane Proteins Aravindan Varadarajan, Felix Oswald, and Yves J. M. Bollen
8. Single-Molecule Fluorescence Microscopy in Living Caenorhabditis elegans Jaap van Krugten and Erwin J. G. Peterman
9. Purification and Application of a Small Actin Probe for Single-Molecule Localization Microscopy Roderick P. Tas, Trusanne G. A. A. Bos, and Lukas C. Kapitein
10. Fluorescence Microscopy of Nanochannel-Confined DNA Fredrik Westerlund, Fredrik Persson, Joachim Fritsche, Jason P. Beech, and Jonas O. Tegenfeldt
11. Use of Single Molecule Fluorescence Polarization Microscopy to Study Protein Conformation and Dynamics of Kinesin--Microtubule Complexes Matthieu P. M. H. Benoit and Hernando Sosa
12. Single Molecule FRET Analysis of DNA Binding Proteins Kathy R. Chaurasiya and Remus T. Dame
PART III
13. Atomic Force Microscopy: An Introduction Melissa C. Piontek and Wouter H. Roos
14. Imaging of DNA and Protein by SFM and Combined SFM-TIRF Microscopy Malgorzata Grosbart, Dejan Ristic, Humberto Sбnchez, and Claire Wyman
15. Atomic Force Microscopy of Protein Shells: Virus Capsids and Beyond Alvaro Ortega-Esteban, N. Martнn-Gonzбlez, F. Moreno-Madrid, Aida Llaurу, Mercedes Hernando-Pйrez, and Pedro J. de Pablo
16. Combined Magnetic Tweezers and Micro-mirror Total Internal Reflection Fluorescence Microscope for Single Molecule Manipulation and Visualization Yeonee Seol and Keir C. Neuman
17. Tethered Particle Motion: An Easy Technique for Probing DNA Topology and Transcription Factor Interactions Daniel T. Tovari, Yan Yan, Laura Finzi, and David Dunlap
18. Single-Molecule Measurements Using Acoustic Force Spectroscopy (AFS) Douwe Kamsma, and Gijs J.L. Wuite
19. Repurposing a Benchtop Centrifuge for High-Throughput Single-Molecule Force Spectroscopy Daren Yang, and Wesley P. Wong
Автор: Lyubomir Vassilev; David Fry Название: Small-Molecule Inhibitors of Protein-Protein Interactions ISBN: 3642266703 ISBN-13(EAN): 9783642266706 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this volume, the editors have collected the knowledgeable insights of researchers who have achieved success in addressing the difficult problem of inhibiting protein-protein interactions.
Описание: Inthis thesis single-molecule fluorescence resonance energy transfer(FRET)spectroscopy was used to study the folding of a protein that belongsto the large and important family of repeat proteins.
Автор: Mahesh Uttamchandani; Shao Q. Yao Название: Small Molecule Microarrays ISBN: 1493965824 ISBN-13(EAN): 9781493965823 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Small molecule microarrays (SMM) were introduced in 1999 and within just a short span of time, have established themselves as a vibrant next generation platform for high-throughput screening. Small Molecule Microarrays: Methods and Protocols consolidates a significant collection of examples, which serve to guide researchers toward ways in which SMM technology may be effectively deployed for multiplexed screening, drug discovery and ligand identification. The volume is organized into three sections covering microarray fabrication, imaging modes, and discovery approaches. The chapters cover a range of small molecule library types, ranging from synthetic combinatorial libraries to peptide and carbohydrate libraries, with lessons and techniques that can be widely applied. Written in the highly successful Methods in Molecular Biology series, format, chapters include introductions of their respective topics, lists of the requisite materials and reagents, step-by-step and readily reproducible laboratory protocols as well as vital tips on troubleshooting and advice on avoiding known pitfalls. Authoritative and cutting-edge, Small Molecule Microarrays: Methods and Protocols provides meticulous insights into the successful applications of SMM, by experts in the field. Building on this collection of knowledge, the volume seeks to inspire a future generation of microarray practitioners to propel this significant technology to even greater heights
Автор: Sylvain Celanire; Sonia Poli Название: Small Molecule Therapeutics for Schizophrenia ISBN: 3319378945 ISBN-13(EAN): 9783319378947 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drug ability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine.
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