Protein Kinase CK2 — From Structure to Regulation, Khalil Ahmed; J.E. Allende; Olaf-Georg Issinger

Автор: Mario D. Cordero; Benoit Viollet
Название: AMP-activated Protein Kinase
ISBN: 3319435876 ISBN-13(EAN): 9783319435879
Издательство: Springer
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Описание: AMPK has emerged as an important integrator of signals that control energy balance through the regulation of multiple biochemical pathways in eukaryotes. This book focuses on the implications of AMPK as a master metabolic regulator in diseases, including new methods and animal models. The contributions are written by leading experts in the field and give an extensive overview of the current knowledge of AMPK biology and the role of AMPK in health and disease. 

Автор: Khalil Ahmed; Olaf-Georg Issinger; Ryszard Szyszka
Название: Protein Kinase CK2 Cellular Function in Normal and Disease States
ISBN: 3319145436 ISBN-13(EAN): 9783319145433
Издательство: Springer
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Описание: Protein kinase CK2 (formerly casein kinase II or 2) is known to play a critical role in the control of cell growth and cell death and is thus intimately involved in the development of cancer. More specifically, CK2 has been found to be elevated in all cancers examined. While CK2 levels are known to be high in proliferating normal cells, CK2 has also been found to be a potent suppressor of apoptosis and is a link to the cancer cell phenotype, which is characterized by deregulation of both cell proliferation and cell death. Indeed, it would appear that CK2 impacts many of the hallmarks of cancer and it has now gained considerable attention as a potential target for cancer therapy. Protein Kinase CK2 and Cellular Function in Normal and Disease States increases knowledge of the role of CK2 in the development of cellular dysfunction and emphasizes that this protein may serve as a target of drug development for improved cancer therapy. In addition, it is a handy tool that provides cancer researchers, graduate students, and all scientists involved in CK2 research with one main source for the latest advances in CK2 research.

Автор: Khalil Ahmed; E. Chambaz; Olaf-Georg Issinger
Название: A Molecular and Cellular View of Protein Kinase CK2
ISBN: 1461346487 ISBN-13(EAN): 9781461346487
Издательство: Springer
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Описание: It is now generally recognized that protein kinase signaling is involved in virtually every aspect of cell function, including growth and proliferation. The field of protein phosphorylation, including the enzymes involved in this post-translational modification, continues to advance at a fascinating pace.
Since the first international meeting on this topic, held in Heidelberg in 1994, several new avenues of CK2 research have emerged despite persistent deficiencies in our understanding of the regulation of its activity. Among the significant new directions are studies related to the structure of the enzyme, especially its crystal structure, as well as an interesting aspect of CK2 function that involves its subunits as binding partners of several other proteins. In addition, new data have been gathered on the role of CK2 in transcription as well as in certain other cellular functions. To address these various aspects of the progress of CK2, a number of key scientists from different parts of the world came together at the second international meeting on A Molecular and Cellular View of Protein Kinase CK2', held at Villard de Lans near Grenoble on September 24-26, 1997. The meeting was attended by nearly 50 participants and included 28 presentations, which provide a view of the latest progress on protein kinase CK2.

Автор: Hideyuki Mukai
Название: Protein Kinase Technologies
ISBN: 1493962426 ISBN-13(EAN): 9781493962426
Издательство: Springer
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Описание: This book examines recent methodologies and techniques generally applicable to protein kinase research as well as to individual protein kinases which require special attention in neuroscience. Covers recent progress in individual protein.

Автор: Alastair D. Reith
Название: Protein Kinase Protocols
ISBN: 1617371416 ISBN-13(EAN): 9781617371417
Издательство: Springer
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Цена: 20263.00 р.
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Автор: Marcelo G. Kazanietz
Название: Protein Kinase C in Cancer Signaling and Therapy
ISBN: 1617796913 ISBN-13(EAN): 9781617796913
Издательство: Springer
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Цена: 41787.00 р.
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Описание: Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980`s with its identification as an effector of phorbol esters, natural products with tumor promoting activity.

Автор: Alexandra C. Newton
Название: Protein Kinase C Protocols
ISBN: 1617373354 ISBN-13(EAN): 9781617373350
Издательство: Springer
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Цена: 23058.00 р.
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Описание: Since the discovery that protein kinase C (PKC) transduces the ab- dance of signals that result in phospholipid hydrolysis, this enzyme has been at the forefront of research in signal transduction. The book ends with a presentation of genetic approaches to study PKC (Part X) and a discussion of approaches used to study PKC in disease (Part XI).

Автор: Lodewijk V. Dekker
Название: Protein Kinase C
ISBN: 1441934197 ISBN-13(EAN): 9781441934192
Издательство: Springer
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Описание: Protein Kinase C is a pivotal component of the mechanism that allows a cell to respond to its changing environment. The remaining chapters contain overviews of the function of Protein Kinase C, both in lower organisms and in mammalian cells, the latter with a focus on immune cells and nerve cells.