Cholesterol and Presynaptic Glutamate Transport in the Brain, Tatiana Borisova
Автор: Robert W. Gereau; Geoffrey Swanson Название: The Glutamate Receptors ISBN: 1627039201 ISBN-13(EAN): 9781627039208 Издательство: Springer Рейтинг: Цена: 36570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This insightful and comprehensive book covers nearly every aspect of glutamate receptor structure and function for the working researcher and student.
Автор: Arne Schousboe; Ursula Sonnewald Название: The Glutamate/GABA-Glutamine Cycle ISBN: 3319450948 ISBN-13(EAN): 9783319450940 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term “The Glutamate-Glutamine Cycle.” In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book.
A number of leading experts in neuroscience including intermediary metabolism, enzymology and transporter physiology have contributed to this book which provides comprehensive discussions of these different aspects of the functional importance of the glutamate-glutamine cycle coupling homeostasis of glutamatergic, excitatory neurotransmission to basic aspects of brain energy metabolism. This book will be of particular importance for students as well as professionals interested in these fundamental processes involved in brain function and dysfunction.
Автор: LOVINGER; DUNWIDDIE Название: Presynaptic Receptors in the Mammalian Brain ISBN: 1468468278 ISBN-13(EAN): 9781468468274 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Sumiko Mochida Название: Presynaptic Terminals ISBN: 4431551654 ISBN-13(EAN): 9784431551652 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book brings together leading international experts to discuss recent advances in functional studies on key proteins and protein complexes involved in each synaptic vesicle phase. These include proteins that control the final step of neurotransmitter release, in response to a neural signal, and the first step of vesicle endocytosis, which helps maintain stable neurotransmitter release in response to unceasing neural signals arriving at presynaptic terminals. Neural networks transmit input and output signals of action potentials using chemical synapses. The strength of the signal from one to another neuron can be tuned by the neural signal itself as it induces Ca2+ entry and by other neurons’ signals that modify Ca2+ entry through voltage-gated Ca2+ channels at the active zone, where chemical neurotransmitters are released from synaptic vesicles via exocytosis. Synaptic vesicles are docked and primed at the active zone prior to exocytosis and are endocytosed after exocytosis for reuse at a small presynaptic terminal. Recycled vesicles are refilled with transmitters and stored for a future round of exocytosis. Thus, synaptic vesicles in presynaptic terminals go through various phases. Each vesicle phase is well orchestrated by numerous proteins and advance step-by-step with neural activities. The fine regulations of synaptic vesicle phases by numerous proteins is an exciting subject, and systematic, well-organized explanations in this book will help the reader easily learn about complicated molecular mechanisms in presynaptic terminals.
Автор: Stephens Gary Название: Modulation of Presynaptic Calcium Channels ISBN: 9400763336 ISBN-13(EAN): 9789400763333 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents recent advances in knowledge of the regulation of presynaptic Ca2+ channels. These represent one of the most widely modulated proteins in the body, target of a range of effector pathways and drugs; this range will be fully represented here.
Описание: ATP acts as main energy source and is pivotal for numerous signaling cascades both inside the cells (by fuelling various transport systems and donating phosphate groups) and between the cells (by chemical transmission).
Автор: Gabriela K. Popescu Название: Ionotropic Glutamate Receptor Technologies ISBN: 1493928112 ISBN-13(EAN): 9781493928118 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This detailed volume explores key technologies that are used currently to investigate iGluR structure, function and physiology.
Автор: Daniel Monaghan; Robert Wenthold Название: The Ionotropic Glutamate Receptors ISBN: 1461284422 ISBN-13(EAN): 9781461284420 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The field of the excitatory amino acids was born when L-glutamate and L-aspartate were found to be potent convulsants (Hayashi, 1954), and were subsequently found to excite neurons directly (Curtis, Phillis, and Watkins, 1959). Although these studies initiated the hypothesis of glutamate-mediated neurotransmission, it was noted that the ubiquitous actions of glutamate could also reflect a general, nonspecific property of glutamate on neuronal mem- branes. It was not until 20 years later that pharmacological, physiological, and biochemical studies provided convincing evidence for a neurotransmitter role for glutamate in the mammalian central nervous system (CNS). With the critical demonstration that the pharmacologically defined glutamate receptors mediate synaptic currents, glutamate rapidly became widely accepted as a majorneurotransmitter by the mid-1980s. This breakthrough, together with the simultaneous findings that glutamate receptors are involved in many essential, as well as pathological, processes in the CNS, instantly transformed the study of glutamate receptors into one of the fastest-growing and most exciting areas of neuroscience. With the cloning of numerous ionotropic glutamate receptor subunits over the last six years, the field has experienced another dramatic acceleration in the understanding of receptor action and in providing the first clear insights into the molecular bases underlying the wealth of pharmacological and physiological data on these receptors.
Автор: Gabriela K. Popescu Название: Ionotropic Glutamate Receptor Technologies ISBN: 1493948954 ISBN-13(EAN): 9781493948956 Издательство: Springer Рейтинг: Цена: 13275.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This detailed volume explores key technologies that are used currently to investigate iGluR structure, function and physiology.
Автор: Peter Jonas; Hannah Monyer Название: Ionotropic Glutamate Receptors in the CNS ISBN: 3540661204 ISBN-13(EAN): 9783540661207 Издательство: Springer Рейтинг: Цена: 85111.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With contributions by numerous experts
Автор: Barbara H. Herman Название: Glutamate and Addiction ISBN: 161737234X ISBN-13(EAN): 9781617372346 Издательство: Springer Рейтинг: Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In Glutamate and Addiction, world-renowned scientific experts critically review all of the evidence for the role of glutamatergic systems in opiate, stimulant, and alcohol addiction.
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