miRNomics: MicroRNA Biology and Computational Analysis, Malik Yousef; Jens Allmer
Автор: Zhang Название: RNAi and microRNA-Mediated Gene Regulation in Stem Cells ISBN: 1607617684 ISBN-13(EAN): 9781607617686 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This cutting-edge text will be a valuable resource for scientists and aspiring graduate students interested in the intersection of RNAi, miRNA, and stem cell molecular biology and exciting areas of research such as regenerative medicine and cancer.
Автор: Singh Shree Ram Название: MicroRNA in Development and in the Progression of Cancer ISBN: 1489980644 ISBN-13(EAN): 9781489980649 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: miRNAs are a class of endogenous, small non-protein coding RNA molecules (~ 22 nucleotides) which are novel post-transcriptional regulators of gene expression. Since we have hundreds of miRNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest that miRNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF-? and EGFR. Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease. Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many miRNAs in several cancer initiating cells. Several miRNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in self-renewal, differentiation, chemoresistance and tumorigenesis. The volume will give a comprehensive account of important advancements in the area of miRNAs and cancer.
Автор: Rani Название: MicroRNA Profiling ISBN: 1493965220 ISBN-13(EAN): 9781493965229 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume includes comprehensive descriptions of miRNA biogenesis and their role in the development and progression of various human diseases. The first few chapters of MicroRNA Profiling: Methods and Protocols discuss the effects of over-expressing and repressing of a target miRNA and their effects on cell viability and proliferation. The next few chapters explore the protocols for total RNA isolation from cells and cell-derived product including formalin fixed paraffin embedded tissue and plant tissue. The last few chapters discuss isolation and characterization of exosomes from medium conditioned by cell lines, serum, and plasma specimens. This book also includes discussions of several software tools, such as miRandola, PicTar, DIANA, and miRWalk. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Comprehensive and cutting-edge, MicroRNA Profiling: Methods and Protocols is a valuable resource for anyone interested in the field of Micro RNAs.
Автор: Tamas Dalmay Название: MicroRNA Detection and Target Identification ISBN: 1493968645 ISBN-13(EAN): 9781493968640 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This collection of miRNA detection and target identification protocols details new developments in traditional detection such as northern blot, quantitative real-time PCR and in situ hybridization, and guides through novel approaches such as nanotechnology, microfluidics, based detection methods, miRNAs as biomarkers and others.
Автор: Jingshan Huang; Glen M. Borchert; Dejing Dou; Jun Название: Bioinformatics in MicroRNA Research ISBN: 1493970445 ISBN-13(EAN): 9781493970445 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
1. MicroRNAs, Long Non-Coding RNAs, and Their Functions in Human Disease
Min Xue, Ying Zhuo, and Bin Shan
2. MicroRNA Expression: Protein Participants in MicroRNA Regulation
4. MicroRNAs: Biomarkers, Diagnostics, and Therapeutics
Weili Huang
5. Relational Databases and Biomedical Big Data
N.H. Nisansa D. de Silva
6. Semantic Technologies and Bio-Ontologies
Fernando Gutierrez
7. Genome-Wide Analysis of MicroRNA-Regulated Transcripts
David Chevalier and Glen M. Borchert
8. Computational Prediction of MicroRNA Target Genes, Target Prediction Databases, and Web Resources
Justin T. Roberts and Glen M. Borchert
9. Exploring MicroRNA:: Target Regulatory Interactions by Computing Technologies
Yue Hu, Wenjun Lan, and Daniel Miller
10. The Limitations of Existing Approaches in Improving MicroRNA Target Prediction Accuracy
Rasiah Loganantharaj and Thomas A. Randall
11. Genomic Regulation of MicroRNA Expression in Disease Development
Feng Liu
12. Next Generation Sequencing for MicroRNA Expression Profile
Yue Hu, Wenjun Lan, and Daniel Miller
13. Handling High-Dimension (High-Feature) MicroRNA Data
Yue Hu, Wenjun Lan, and Daniel Miller
14. Effective Removal of Noisy Data Via Batch Effect Processing
Ryan G. Benton
15. Logical Reasoning (Inferencing) on MicroRNA Data
Jingsong Wang
16. Machine Learning Techniques in Exploring MicroRNA Gene Discovery, Targets, and Functions
Sumi Singh, Ryan G. Benton, Anurag Singh, and Anshuman Singh
17. Involvement of MicroRNAs in Diabetes and Its Complications
Bin Wu and Daniel Miller
18. MicroRNA Regulatory Networks as Biomarkers in Obesity: The Emerging Role
Lihua Zhang, Daniel Miller, Qiuping Yang, and Bin Wu
19. Expression of MicroRNAs in Thyroid Carcinoma
Gaohong Zhu, Lijun Xie, and Daniel Miller
Автор: Suresh Alahari Название: MicroRNA in Cancer ISBN: 9401784930 ISBN-13(EAN): 9789401784931 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book explores the rapidly emerging field of microRNA biology, highlighting the importance of microRNAs in cancer. This first reference of its kind will benefit working scientists in cancer biology, as well as advanced undergraduate and graduate students.
Автор: Ulf Schmitz; Olaf Wolkenhauer; Julio Vera Название: MicroRNA Cancer Regulation ISBN: 9402400796 ISBN-13(EAN): 9789402400793 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book discusses the role of microRNAs in the formation and progression of solid tumors. The main focus is on computational methods and applications, together with experimental techniques used to approach all aspects of microRNA regulation in cancer.
Автор: Malik Yousef; Jens Allmer Название: miRNomics: MicroRNA Biology and Computational Analysis ISBN: 1493962647 ISBN-13(EAN): 9781493962648 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In miRNomics: MicroRNA Biology and Computational Analysis, expert researchers in the field present an overview of the current state of the art and aim to put the respective areas of research into a larger perspective.
Автор: Shao-Yao Ying Название: MicroRNA Protocols ISBN: 1493976001 ISBN-13(EAN): 9781493976003 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This volume focuses on the analysis of miRNA and its many components such as targets and expression profiling, regulation of gene expression, miRNA detection in biofluids, and its application in cancer and wound healing. The chapters in this book explore topics that's cover biogenesis, isolation and profiling of miRNA, exosomal miRNAs, and the study of the functional significance of miRNAs. The chapters also cover screening miRNAs in mR-302/367 induced iPSCs, exosomal miRNAs from iPSC-derived cardiomyocytes proliferation, and the recently discovered sugar-like RNA glycylglycerins. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and thorough, MicroRNA Protocols, Third Edition is a valuable resource that provides researchers with a comprehensive study of miRNAs and its numerous components and uses.
Автор: Baohong Zhang; Edmund J. Stellwag Название: RNAi and microRNA-Mediated Gene Regulation in Stem Cells ISBN: 149395749X ISBN-13(EAN): 9781493957491 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Recent stem cell research has revealed that miRNA and RNAi-mediated gene regulation is one of the vital determinates controlling the state of cell differentiation, with the small RNAs serving as key elements involved in regulatory network control of pluripotent cell fate determination. In RNAi and microRNA-Mediated Gene Regulation in Stem Cells: Methods, Protocols, and Applications, expert authors from laboratories across the globe contribute an accessible compendium of up-to-date, proven methods focused on the study of the titular topic. Divided into three sections, the book first gives a brief introduction to RNAi and miRNAs in stem cells, with a focus on the current status of research and future perspectives, then it continues with detailed methods and protocols for RNAi screening, transfection, and the knockdown of specific genes and pathways in several animal species, including humans and mice, concluding with a section on recently developed methods for identification of miRNAs, including a general protocol for preparation and analysis of miRNA libraries for deep sequencing, knock down of a specific gene using miRNA-based shRNA, and miRNA expression analysis using qRT-PCR. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes highlighting tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, RNAi and microRNA-Mediated Gene Regulation in Stem Cells: Methods, Protocols, and Applications serves as a valuable resource for scientists and aspiring graduate students interested in the intersection of RNAi, miRNA, and stem cell molecular biology and the exciting areas of medicine, including regenerative medicine, aging, cancer, and neurological disorders, that can be advanced through this expanding area of research.
Автор: Wei Wu Название: MicroRNA and Cancer ISBN: 1493957740 ISBN-13(EAN): 9781493957743 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Authoritative and cutting-edge, this book provides the basic principles of experimental and computational methods for microRNA study in cancer research. It provides a firm grounding for those who wish to further develop their own applications.
Автор: Fazlul H. Sarkar Название: MicroRNA Targeted Cancer Therapy ISBN: 3319051334 ISBN-13(EAN): 9783319051338 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs) and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass.
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