Описание: In multicellular organisms, communication between cells involves secretion of proteins that bind to receptors on neighboring cells. While this has been well documented, another mode of intercellular communication has recently become the subject of increasing interest: the release of exosomes. In cancer, tumor exosomes are involved in various aspects of pathogenesis, including proliferation, immunosuppression, and metastasis. Given the ability of exosomes to export unneeded endogenous molecules from cells, these structures hold great potential as anticancer therapeutic agents. They are also being studied as prognostic markers for cancer.
Описание: This book explores recent findings on vesicle-based information transfer by exosomes. It provides an overview of exosomes biology and function and discusses the role of exosomal tetraspanins in tumor progression.
Название: Handbook of Therapeutic Biomarkers in Cancer ISBN: 9814364657 ISBN-13(EAN): 9789814364652 Издательство: Taylor&Francis Рейтинг: Цена: 21437.00 р. Наличие на складе: Нет в наличии.
Описание: In this volume, a team of internationally recognized experts provide an in-depth description of therapeutic biomarkers across a broad area of cancer research and oncology. With a wealth of information to specific therapies, each chapter focuses on a class of targeted chemotherapy agents. The book describes established and evolving diagnostic tests for therapeutic biomarkers that predict benefit, response, resistance, or drug side effects from specific therapeutic interventions. This volume is an essential handbook for health professionals and scientists researching current applicable biomarkers in oncology.
Автор: Hideo Kimura Название: Hydrogen Sulfide and its Therapeutic Applications ISBN: 370911974X ISBN-13(EAN): 9783709119747 Издательство: Springer Рейтинг: Цена: 16070.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The metabolism of sulfur especially by sulfurtransferases had been intensively studied in mid 1900’s. Three enzymes, cystathionine ?–synthase (CBS), cystathionine ?–lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST) were found to have the capacity to produce H2S in vitro. However, H2S was recognized simply as a by-product of the metabolic pathways or as a marker for evaluating the activity of enzymes rather than as a physiological active molecule. In the late 1980’s relatively high concentrations of sulfide were measured in the brain that led to the successive studies of identifying the physiological functions of H2S. Recently, the steady-state concentrations of H2S have been re-evaluated and found to be much less than that initially measured. However, despite these differences, such re-evaluations served to further confirm the existence of H2S in mammalian tissues. H2S is produced in almost every organ and plays various roles such as neuromodulation, vasodilation, insulin release, inflammation, angiogenesis and cytoprotection. The unregulated production of H2S and improper responses of target molecules are involved in the pathogenesis of various diseases. This book focuses on these topics as well as on the recent progress in the biology and the therapeutic development of this molecule.
Автор: Daniel Lafontaine; Audrey Dub? Название: Therapeutic Applications of Ribozymes and Riboswitches ISBN: 1493962965 ISBN-13(EAN): 9781493962969 Издательство: Springer Рейтинг: Цена: 14673.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Methods in Molecular Biology book offers a complete overview of protocols used in the development of RNA molecule as drugs and drug target. Includes material and reagent lists, reproducible lab protocols, known pitfalls, troubleshooting tips and more.
Applications of Mass Spectrometry Imaging to Cancer, the latest volume in the Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents original reviews on applications of mass spectrometry imaging to cancer.
Описание: This book provides an overview of advances and recent trends in medicinal plant sciences along with biotechnological interventions that has made it increasingly feasible to exploit these natural resources and transform traditional medicines into modern drugs.
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