Emery and rimoin`s principles and practice of medical genetics and genomics,
Автор: Peter D Turnpenny, Sian Ellard, Ruth Cleaver Название: Emery`s Elements of Medical Genetics and Genomics, 16e ISBN: 0702079669 ISBN-13(EAN): 9780702079665 Издательство: Elsevier Science Рейтинг: Цена: 7241.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Long recognized as a leading textbook in this fast-moving field, Emery's Elements of Medical Genetics and Genomics offers current, complete information with a strong basis in practical clinical genetics and genomics for medical school and beyond. The 16th Edition of this award-winning text has been thoroughly updated throughout and includes case-based and multiple-choice questions, end-of-chapter summaries, an extensive glossary, and convenient online access, making it an ideal choice for all medical undergraduates as well as postgraduates seeking to improve their understanding and knowledge.
Includes new case-based studies with questions and answers throughout, in addition to multiple-choice self-assessment questions for study and review.
Covers key topics such as pharmacogenetics, personalized medicine, prenatal testing, reproductive genetics, and ethical and legal issues in medical genetics.
Divides the text into three easy-to-use sections: The Scientific Basis of Human Genetics, Genetics in Medicine and Genomic Medicine, and Clinical Genetics, Counseling and Ethics
Features full-color illustrations and other images that help readers visualize the appearance of genetic disorders and assist with the understanding of complex genetic structures.
Contains learning features such as summary boxes, an extensive glossary of terms, online hyperlinks to important genetics websites and clinical databases, and more.
Presents the extensive knowledge and experience of distinguished editors Peter D. Turnpenny and Sian Ellard, as well as new editor Ruth Cleaver.
Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.
This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Автор: Strachan Название: Human Molecular Genetics ISBN: 0815345895 ISBN-13(EAN): 9780815345893 Издательство: Taylor&Francis Рейтинг: Цена: 12095.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Human Molecular Genetics has been carefully crafted over successive editions to provide an authoritative introduction to the molecular aspects of human genetics, genomics and cell biology.
Maintaining the features that have made previous editions so popular, this fifth edition has been completely updated in line with the latest developments in the field. Older technologies such as cloning and hybridization have been merged and summarized, coverage of newer DNA sequencing technologies has been expanded, and powerful new gene editing and single-cell genomics technologies have been added. The coverage of GWAS, functional genomics, stem cells, and disease modeling has been expanded. Greater focus is given to inheritance and variation in the context of populations and on the role of epigenetics in gene regulation.
Key features:
Fully integrated approach to the molecular aspects of human genetics, genomics, and cell biology
Accessible text is supported and enhanced throughout by superb artwork illustrating the key concepts and mechanisms
Summary boxes at the end of each chapter provide clear learning points
Annotated further reading helps readers navigate the wealth of additional information in this complex subject and provides direction for further study
Reorganized into five sections for improved access to related topics
Also new to this edition - brand new chapter on evolution and anthropology from the authors of the highly acclaimed Human Evolutionary Genetics
A proven and popular textbook for upper-level undergraduates and graduate students, the new edition of Human Molecular Genetics remains the 'go-to' book for those studying human molecular genetics or genomics courses around the world.
For decades, Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics has served as the ultimate resource for clinicians integrating genetics into medical practice.
With nearly 5,000 pages of detailed coverage, contributions from over 250 of the world's most trusted authorities in medical genetics, and a series of 11 volumes available for individual sale, the Seventh Edition of this classic reference includes the latest information on seminal topics such as prenatal diagnosis, genome and exome sequencing, public health genetics, genetic counseling, and management and treatment strategies to complete its coverage of this growing field for medical students, residents, physicians, and researchers involved in the care of patients with genetic conditions. This comprehensive yet practical resource emphasizes theory and research fundamentals related to applications of medical genetics across the full spectrum of inherited disorders and applications to medicine more broadly.
In Metabolic Disorders, leading physicians and researchersthoroughly examine medical genetics as applied to a range of metabolic disorders, with emphasis on understanding the genetic mechanisms underlying these disorders, diagnostic approaches, and therapeutics that make use of current genomic technologies and translational studies. Here genetic researchers, students, and health professionals will find new and fully revised chapters on the genetic basis of body mass, amino acid, carbohydrate, iron, copper, lipo protein, and lipid metabolic disorders, as well as organic acidemias, fatty acid oxidation, and peroxisome disorders among others.
With regular advances in genomic technologies propelling precision medicine into the clinic, Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics: Seventh Edition bridges the gap between high-level molecular genetics and practical application and serves as an invaluable clinical tool for health professionals and researchers.
Автор: Thangadurai Devarajan, Sangeetha Jeyabalan Название: Genomics and Proteomics: Principles, Technologies, and Applications ISBN: 1771881143 ISBN-13(EAN): 9781771881142 Издательство: Taylor&Francis Рейтинг: Цена: 20671.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
The book provides scope and knowledge on advanced techniques and its applications into the modern fields of biotechnology--genomics and proteomics. In this book, different genomics and proteomics technologies and principles are examined. The fundamental knowledge presented in this book opens up an entirely new way of approaching DNA chip technology, DNA array assembly, gene expression analysis, assessing changes in genomic DNA, structure-based functional genomics, protein networks, and so on.
Topics in the book include:
- Different gene products with a similar role in neuronal defense against oxidative
- Gene-gene and gene-environment interactions in genetic epidemiology
- Elucidation of proto-oncogene c-abl function with the use of mouse models and the disease model of chronic myeloid leukemia
- Next-generation sequencing, microbiome evaluation, molecular microbiology, and their impact on human health
- Proteomics and prostate cancer
- RNA interference therapeutics
- Molecular mechanisms of hepatitis C virus entry
- Molecular phylogenetics for elucidation of evolutionary processes from biological data
- The impact of transgenic crops on soil quality, microbial diversity, and plant-associated communities.
- Biotechnological and genomic approaches for abiotic stress tolerance in crop plants
The book will be valuable for biotechnology researchers and bioinformatics professionals and students in all fields of biotechnology and will serve to broaden their knowledge about these newer tools, techniques, innovations, and applications.
Название: Principles and Practices of Plant Genomics, Volume 3 ISBN: 1138116491 ISBN-13(EAN): 9781138116498 Издательство: Taylor&Francis Рейтинг: Цена: 10717.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This book presents the basic and applied aspects of sequencing of genes and genomes and their implication in the fine-scale elucidation of the plant genomes. The third volume presents an overview on the advances of plant genomics made in the past century; deliberations on the genomics resources; concepts, tools, strategies, and achievements of comparative, evolutionary, and functional genomics and whole-genome sequencing. It also presents critical reviews on the already completed genome initiatives and glimpses on the currently progressing genome initiatives. This volume is an ideal reference book for students, scholars and scientists in academia, industry, and government.
Название: Omics in Clinical Practice ISBN: 1771880600 ISBN-13(EAN): 9781771880602 Издательство: Taylor&Francis Рейтинг: Цена: 20671.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This title includes a number of Open Access chapters.
This book serves as an introduction to genomics, proteomics, and transcriptomics, putting these fields in relation to human disease and ailments. The various chapters consider the role of translation and personalized medicine, as well as pathogen detection, evolution, and infection, in relation to genomics, proteomics, and transcriptomics. The topic of companion diagnostics is also covered.
The book is broken into five sections. Part I examines the connection between omics and human disease. Part II looks at the applications for the fields of translational and personalized medicine. Part III focuses on molecular and genetic markers. Part IV describes the use of omics while studying pathogens, and Part V examines the applications for companion diagnostics.
The book:
- Introduces genomics, proteomics, and transcriptomics in relation to human disease and ailments
- Considers the role of translation and personalized medicine in relation to genomics, proteomics, and transcriptomics
- Covers molecular and genetic markers
- Considers the role of genomics, proteomics, and transcriptomics in relation to pathogen detection, evolution, and infection
- Covers companion diagnostics in relation to genomics, proteomics, and transcriptomics clinical applications and research
Автор: Charles, Jill Mondal, Indrani Chattopadhyay, Ranjita Chakrabarty, Ananda Название: Three daughters, three journeys ISBN: 9814745901 ISBN-13(EAN): 9789814745901 Издательство: Taylor&Francis Рейтинг: Цена: 4898.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Cancer threatens the lives of people around the world. Women, in particular, are at risk of certain cancers with a genetic cause. Certain mutations in the BRCA1 and BRCA2 genes put mothers and daughters at risk of breast and ovarian cancers. Unlike many cancers that most commonly occur after age 60, these inheritable cancers threaten women’s lives, health and fertility even when they are young, before most would even begin to go for annual mammogram screenings to check for breast cancer. Three Daughters, Three Journeys takes on the biggest health issue of our time from a global perspective with three heroines fighting for their lives against cancer. Marzena, a Polish oncology nurse, has spent her life treating child patients with cancer. Then, she confronts it in her own family and her own body. Kamola, a rural Indian girl, knows she has symptoms of the same disease that took her mother, but feels afraid to discuss it with her father and brothers, knowing her family cannot afford medical treatment. Kamola confides in Dr Rini Mishra, a doctor testing a new treatment called Neelazin, using a bacterial anticancer protein in food, to destroy cancer cells. Selena, a wealthy woman of color in Chicago, finds out about her genetic risks of breast and ovarian cancer. She has a choice of preventative surgery that will save her life but remove any chance of having children. As she meets women who struggle to afford cancer treatment, Selena dedicates her life to providing affordable homes and counseling to families affected by the disease. Although the drug Neelazin is fictional, the possibility of new cancer treatments using bacterial anticancer proteins is being researched now. A problem with the current chemotherapy for cancer treatment is the high toxicity of most of these drugs, as these drugs can enter both normal and cancer cells, though preferably cancer cells, causing the death of normal cells as well that are important in maintaining health. Another problem is that current chemotherapeutic drugs mostly target a single or few key steps that are important for cancer growth and proliferation and inhibit the growth of cancer cells. The cancer cells respond by quickly changing these single targets, thereby becoming resistant to the drugs, as is reflected in stage IV cancer patients. An alternative to chemotherapy would be to exploit the bacterial evolutionary wisdom and use certain proteins that can have preferential entry to cancer cells in order to minimize normal cell toxicity and multiple targets in cancer cells through protein–protein complex formation, thus reducing resistance development in cancer cells. An interesting advantage of protein drugs is to express them as part of food, and some recent research seems to suggest that oral consumption of such foods may allow the therapeutic protein to reach the blood stream to target the cancer. Women with the genetic risk factors could soon have the choice of taking a pill or such anticancer protein-expressing food to treat or prevent cancer, rather than removing the healthy tissue of the breasts and ovaries. Hopefully, they would not have to choose between fertility and survival, as is the implied message in this book, fictional as it is at this time.
Автор: Vikas Mishra Название: Principles of Epigenetics ISBN: 1773615297 ISBN-13(EAN): 9781773615295 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 25502.00 р. Наличие на складе: Нет в наличии.
Описание: Examines various dimensions of epigenetics and its relationship to human disease. Part I deals with epigenetics in human diseases; Part II covers yeast epigenetics; Part III covers plant epigenetics.
Автор: Bahar Taneri, Esra Asilmaz, T?rem Delikurt, Pembe Название: Human Genetics and Genomics: A Practical Guide ISBN: 3527337482 ISBN-13(EAN): 9783527337484 Издательство: Wiley Рейтинг: Цена: 8395.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Finally meeting the need for a laboratory manual on human genetics, this practical guide is the perfect companion title to all major standard textbooks on the subject. The authors all have a high-level research background and are actively involved in teaching and counseling. Based on a standard curriculum in human genetics, each chapter equals one practical unit of the course and topics range from basics in human inheritance to genetics in major disease clusters and from bioinformatics and personalized medicine to genetic counseling.
Описание: The increased and widespread availability of large network data resources in recent years has resulted in the increased need for effective methods for the analysis of these networks. The challenge is to detect patterns that provide a better understanding of the data. However, this is not a straight forward task because of the size of the data sets and the computer power required for the analyses. The solution is to devise methods for approximately answering the questions posed, and these methods will vary depending on the data sets under scrutiny. This cutting-edge text introduces graph and network theory, cluster analysis and machine learning, before discussing the thought processes and creativity involved in the analysis of large-scale biological and medical data sets, using a wide range of real-life examples. Bringing together leading experts, this inter-disciplinary text provides an ideal introduction to and insight into the field of network data analysis.
Автор: Xia Название: A Mathematical Primer of Molecular Phylogenetics ISBN: 1771887559 ISBN-13(EAN): 9781771887557 Издательство: Taylor&Francis Рейтинг: Цена: 17762.00 р. Наличие на складе: Поставка под заказ.
Описание: The volume provides sufficient mathematical background for young mathematicians and computational scientists, as well as mathematically inclined biology students, to make a smooth entry into the expanding field of molecular phylogenetics.
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