This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.
This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Автор: Fred H. Gage Название: Gene Transfer and Therapy in the Nervous System ISBN: 3642848443 ISBN-13(EAN): 9783642848445 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Uri Gophna Название: Lateral Gene Transfer in Evolution ISBN: 1489986618 ISBN-13(EAN): 9781489986610 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book focuses on the spectrum of adaptive innovations generated by lateral gene transfer in evolution. It looks at the genomic, metabolic and ecological levels as well as examines the integration of new genes into existing networks.
Автор: Heddwyn Jones Название: Plant Gene Transfer and Expression Protocols ISBN: 1489940596 ISBN-13(EAN): 9781489940599 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The development of recombinant DNA technology and methods for transferring recombinant genes into plants has brought about significant advances in plant science.
Автор: Uri Gophna Название: Lateral Gene Transfer in Evolution ISBN: 1461477794 ISBN-13(EAN): 9781461477792 Издательство: Springer Рейтинг: Цена: 22203.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book focuses on the spectrum of adaptive innovations generated by lateral gene transfer in evolution. It looks at the genomic, metabolic and ecological levels as well as examines the integration of new genes into existing networks.
Автор: Edward J. Murray Название: Gene Transfer and Expression Protocols ISBN: 1489944036 ISBN-13(EAN): 9781489944030 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Biology is the study of living things. The classical approach might be described as holistic and descriptive, whereas the modern molecular - proach aims to be investigative, reductionist, and mechanistic . Genes contain all the information for the structure of all living things ; thus, the understanding of how genes are regulated is an important step toward understanding the nature of living things. The study of gene regulation has been made more tractable by the design of simple expe- mental models in which a single gene can be isolated from the milieu of the organism. The new science of molecular biology has introduced techniques that permit the design of such experimental models. In - sence, the genome of the organism is dissected in such a manner that specific genes may now be introduced into an appropriate cell line . Subsequent analysis of the proteins expressed from the genes under study results in the identification of the regulatory DNA sequences .
Автор: Ingo Potrykus; German Spangenberg Название: Gene Transfer to Plants ISBN: 3642489672 ISBN-13(EAN): 9783642489679 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: J. S. Schell; P. Starlinger Название: The Impact of Gene Transfer Techniques in Eucaryotic Cell Biology ISBN: 3642700675 ISBN-13(EAN): 9783642700675 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The 35th N:osbach Colloquium "The Impact of Gene Transfer Techniques in Eukaryotic CeU Biology" brought together a number of speakers interested in various aspects of cellular and developmental biology and over 600 other scientists, who listened to the lectures and participated in the lively discussions.
Автор: R. Kucherlapati Название: Gene Transfer ISBN: 1468451693 ISBN-13(EAN): 9781468451696 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Genetic analysis of microbial systems provided us with the foundation for un- derstanding gene structure, expression, and regulation. As a result, genetic analysis of mam- malian systems had to await the development of parasexual systems.
Автор: Keith L. March Название: Gene Transfer in the Cardiovascular System ISBN: 1461378818 ISBN-13(EAN): 9781461378815 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expressed at a level beneficial for the patient.
Автор: Tom?s G. Villa; Miguel Vi?as Название: Horizontal Gene Transfer ISBN: 3030218619 ISBN-13(EAN): 9783030218614 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book focuses on the evolutionary impact of horizontal gene transfer processes on pathogenicity, environmental adaptation and biological speciation. Newly acquired genetic material has been considered as a driving force in evolution for prokaryotic genomes for many years, with recent technical developments advancing this field further. However, the extent and implications of gene transfer between prokaryotes and eukaryotes still raise controversies. This multi-authored volume introduces various means by which DNA can be exchanged, covers gene transfer between prokaryotes and their viruses as well as between bacteria and eukaryotes, such as fungi, plants and animals, and addresses the role of horizontal gene transfer in human diseases. Aspects discussed also include the relevance for virulence and drug resistance development on one hand, and for the occurrence of naturally derived antibiotics and other secondary metabolites on the other hand. This book offers new insights to anyone interested in genome evolution and the exchange of DNA between the different domains of life, the genetic toolkit for adaptation and the emergence of multidrug resistant bacteria.
Описание: Describes methods for the production of viral and non-viral gene transfer vectors, as well as protocols for critical applications in stem cell biology, cancer, diabetes, HIV and tissue engineering.
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