Описание: This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) – teixobactin and the skyllamycins – with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.
Автор: Jean-Michel M?rillon; C?line Riviere Название: Natural Antimicrobial Agents ISBN: 3030097862 ISBN-13(EAN): 9783030097868 Издательство: Springer Рейтинг: Цена: 21940.00 р. Наличие на складе: Поставка под заказ.
Описание: Documenting the latest research in the field of different pathogenic organisms, this book presents the current scenario about promising antimicrobials in the following areas: Part I. Plants as source of antibacterials, Part II. Naturally occurring antifungal natural products, Part III. Antiparasitic natural products, Part IV. Antiviral natural products. Renowned scientists from the globe have been selected as authors to contribute chapters. Use of plants for various ailments is as old as human civilization and continuous efforts are being made to improve medicinal plants or to product their bioactive secondary metabolites in high amounts through various technologies. About 200,000 natural products of plant origin are known and many more are being identified from higher plants and micro-organisms. Some plants based drugs are used since centuries and there is no alternative medicine for many such drugs as cardiac glycosides. Drug discovery from medicinal plants or marine micro-organisms continues to provide an important source of new drug leads. Research on new antibacterials represents a real and timely challenge of this century, particularly for the treatment of infections caused by clinical isolates that show multidrug resistance. The main microorganisms involved in the resistance process have been identified and given the acronym ESKAPE for Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa and Enterobacteriaceae. Multidrug resistant Mycobacterium tuberculosis including highly drug-resistant strains (XDR-TB) has also emerged as one of the most important clinical challenges of this century. Plants of diverse taxa and marine micro-organisms are rich source of these antimicrobials. An attempt has been made to compile the recent information about natural sources of antibacterials and their sustainable utilization. Increased panic of these pathogens warrants a growing demand for research to undertake the threat of multidrug resistance. The search for new antifungal, antiparasitic and antiviral natural products is far from devoid of interest. According to the WHO report in 2013, malaria still represents some 207 million cases worldwide and more than 3 billion of people are still exposed to this risk. Similarly, about 350 million people are considered at risk of contracting leishmaniasis. The fight against some viruses also requires that the research on natural products continue. For example, even if an antiretroviral with direct action was recently approved in Europe in 2013, its high cost does not allow to offer it to an exposed population in countries where the cost of drugs remains a problem for a large part of the population. These books are useful to researchers and students in microbiology, biotechnology, pharmacology, chemistry and biology as well as medical professionals.
Название: Biofilms, Infection, and Antimicrobial Therapy ISBN: 0367392194 ISBN-13(EAN): 9780367392192 Издательство: Taylor&Francis Рейтинг: Цена: 9798.00 р. Наличие на складе: Поставка под заказ.
Описание:
Rather than existing in a planktonic or free-living form, evidence indicates that microbes show a preference for living in a sessile form within complex communities called biofilms. Biofilms appear to afford microbes a survival advantage by optimizing nutrition, offering protection against hostile elements, and providing a network for cell-to-cell signaling and genetic exchange.
Biofilms, Infection, and Antimicrobial Therapy provides an in-depth exploration of biofilms, offering broad background information, as well a detailed look at the serious concerns to which biofilm-associated infections give rise.
Prosthetic device infections, such as those involving artificial heart valves, intravascular catheters, or prosthetic joints, are prime examples of biofilm-associated infections. With the increasing use of such devices in the modern practice of medicine, the prevalence of these infections is expected to increase. Unfortunately, one of the most troubling characteristics of microbes found in biofilms is a profound resistance to antimicrobial agents.
As biofilm-associated infections are particularly difficult to treat, they result in significant mortality, morbidity, and increased economic burden. Clearly, a better understanding of the pathogenesis of these infections and improved means for prevention and treatment are urgently needed!
InBiofilms, Infection, and Antimicrobial Therapy, Drs Pace, Rupp, and Finch assemble the contributions of more than 50 of the world's leading authorities on microbial biofilms who present recent findings on antibacterial tolerance and bacterial persistence associated with biofilms and discuses the implications of those findings with regard to human health. They explore the molecular mechanisms of bacterial adherence, biofilm formation, regulation of biofilm maintenance, and cell-to-cell communication and present the latest information on various treatment protocols that should aid physicians in the treatment o
Автор: Jeffrey K. Aronson Название: Meyler`s Side Effects of Antimicrobial Drugs, ISBN: 0444532722 ISBN-13(EAN): 9780444532725 Издательство: Elsevier Science Рейтинг: Цена: 8420.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Suitable for internal medicine physicians and general practitioners who prescribe antibiotic drugs, like penicillin and tetracycline that cure bacterial infections, and antiviral drugs used to treat patients with HIV and herpes viruses.
Название: Antimicrobial therapeutics reviews ISBN: 1573317888 ISBN-13(EAN): 9781573317887 Издательство: Wiley Рейтинг: Цена: 14810.00 р. Наличие на складе: Поставка под заказ.
Описание: This is the inaugural volume in a new series of reviews. Each annual volume will contain authoritative reviews of developing research topics in antimicrobial therapeutics. Authors will describe how the research being reviewed can be applied to real-world problems.
Автор: Eswari, Jujjvarapu Satya (national Institute Of Technology, Raipur, India) Dhagat, Swasti (national Institute Of Technology, Raipur, India) Yadav, Man Название: Computer-aided design of antimicrobial lipopeptides as prospective drug candidates ISBN: 1138497509 ISBN-13(EAN): 9781138497504 Издательство: Taylor&Francis Рейтинг: Цена: 26796.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The authors focus on the properties of various lipopeptides which are produced as metabolites by bacteria and have shown to have antimicrobial properties. They provide a step-by-step method in identifying drug molecules for target compounds and testing various properties for drug efficacy. Both experienced researchers and beginners will benefit.
Автор: Nightingale Charles H Название: Antimicrobial Pharmacodynamics ISBN: 0824729250 ISBN-13(EAN): 9780824729257 Издательство: Taylor&Francis Рейтинг: Цена: 33686.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Antimicrobial Pharmacodynamics in Theory and Clinical Practice
Автор: Wilson John W Название: Mayo Clinic Antimicrobial Therapy ISBN: 0190696923 ISBN-13(EAN): 9780190696924 Издательство: Oxford Academ Рейтинг: Цена: 5780.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The medical management of infectious diseases and antimicrobial therapy can be a daunting task for health care professionals. Infectious diseases experts at Mayo Clinic provide a coordinated, unified approach to infectious disease treatment for the general patient population as well as the complex patients seen at this internationally renowned destination medical center. Over twenty contributors represent the spectrum of infectious disease experience within the Mayo Clinic framework of patient-centered care. Highlights of Mayo Clinic Antimicrobial Therapy: Quick Guide, Third Edition include simplified and thorough drug dosing recommendations for renal function and renal replacement therapies, drugs of choice for specific organisms (including bacteria, fungi, and viruses), and updated and simplified antimicrobial and management recommendations for specific infectious syndromes. New features of the third edition include dosing recommendations for extended infusions and obese and neonatal patient populations and treatment options targeted for hepatitis B and C infections, prosthetic joint infections, post-transplant infections, and infections resulting from bioterrorism. This compact, user-friendly resource brings the specialized knowledge of Mayo Clinic to your fingertips.
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