Описание: This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) – teixobactin and the skyllamycins – with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.
Автор: James A. Poupard; Lori R. Walsh; Bruce Kleger Название: Antimicrobial Susceptibility Testing ISBN: 1475792085 ISBN-13(EAN): 9781475792089 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: J ames Poupard Lori Walsh Bruee Kleger ix CONTENTS 1 Introduction 1: CURRENT METHODS The Evolution of Antimicrobial Susceptibility Testing Methods . Bartlett Areas of Recent Emphasis of the National Committee for Clinical Laboratory Standards Subcommittee on Antimicrobial Susceptibility Testing .
Описание: This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery.
Автор: J. F. Snell; J. W. Corcoran; K. L. Arora; F. E. Ha Название: Mechanism of Action of Antimicrobial and Antitumor Agents ISBN: 3642463061 ISBN-13(EAN): 9783642463068 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume is the third in the series devoted to Antibiotics initiated by Springer Verlag in 1967.
Описание: Offers many antibiotics and antimicrobial compounds: in development, experimental, and in use. This title covers chemistry and synthesis, classification, structure-activity relationships, mechanisms of action and resistance, breakpoints, in vitro/in vivo activities, epidemiology, pharmacokinetics, metabolism, and adverse events.
Автор: Villa Tomas G. Название: Antimicrobial Compounds ISBN: 364240443X ISBN-13(EAN): 9783642404436 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book reviews the current state-of-the-art in antimicrobial research and discusses new strategies for the design and discovery of novel therapies. It combines basic research with clinical applications.
Автор: Paul Robert Hansen Название: Antimicrobial Peptides ISBN: 1493967355 ISBN-13(EAN): 9781493967353 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume provides basic and advanced laboratory protocols for the non-specialist and the experienced researcher. Chapters are divided into three parts covering synthesis and characterization of AMPs, studying the interaction of AMPs with model systems or bacteria, and assaying selected biological activities of AMPs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Antimicrobial Peptides: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Автор: Grumezescu, Alexander Mih Название: Antimicrobial Nanoarchitectonics ISBN: 0323527337 ISBN-13(EAN): 9780323527330 Издательство: Elsevier Science Рейтинг: Цена: 26107.00 р. Наличие на складе: Поставка под заказ.
Описание:
Antimicrobial Nanoarchitectonics: From Synthesis to Applications brings together recent research in antimicrobial nanoparticles, specifically in the sustained and controlled delivery of antimicrobials. Particular attention is given to i) reducing the side effects of antibiotics, ii) increasing the pharmacological effect, and iii) improving aqueous solubility and chemical stability of different antimicrobials. In addition, antimicrobial nanoparticles in drug delivery are discussed extensively. The book also evaluates the pros and cons of using nanostructured biomaterials in the prevention and eradication of infections. It is an important reference resource for materials scientists and bioengineers who want to learn how nanomaterials are used in antimicrobial therapy.
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