Автор: Thorsteinn Loftsson Название: Essential Pharmacokinetics ISBN: 0128014113 ISBN-13(EAN): 9780128014110 Издательство: Elsevier Science Рейтинг: Цена: 8983.00 р. Наличие на складе: Поставка под заказ.
Описание: Essential Pharmacokinetics: A Primer for Pharmaceutical Scientists is an introduction to the concepts of pharmacokinetics intended for graduate students and new researchers working in the pharmaceutical sciences. This book describes the mathematics used in the mammillary model as well as the application of pharmacokinetics to pharmaceutical product development, and is useful as both a self-study and classroom resource. Content coverage includes detailed discussions of common models and important pharmacokinetic concepts such as biological half-life, clearance, excretion, multiple dosage regimens and more. Numerous equations, practical examples and figures are incorporated to clearly illustrate the theoretical background of pharmacokinetic behavior of drugs and excipients.
Автор: Aldo Rescigno Название: Foundations of Pharmacokinetics ISBN: 1475787391 ISBN-13(EAN): 9781475787399 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book has its origin in my experience as a teacher of pharmacokinetics in many universities in four different continents. Chapters 13 to 17 show how different parameters of importance in pharmacokinetics can be exactly defined and measured.
Автор: Devarakonda R. Krishna; Ulrich Klotz Название: Clinical Pharmacokinetics ISBN: 3540524584 ISBN-13(EAN): 9783540524588 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: 2 Multiple dosing The basic mathematical relationships applicable to single dose administration kinetics are also valid (with slight modifications) for multiple dose kinetics.
Описание: Updated with the latest clinical advances, Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition, explains the relationship between drug administration and drug response, taking a conceptual approach that emphasizes clinical application rather than science and mathematics. Bringing a real-life perspective to the topic, the book simplifies concepts and gives readers the knowledge they need to better evaluate drug applications.
Key updates reflect advances in PK/PD as related to clinical decision making and drug research and development.
An emphasis on the clinical relevance of drugs makes the book especially applicable to pharmacy students preparing for a career in clinical practice.
Hundreds of graphs and tables provide visual representations of key pharmacokinetic/pharmacodynamic principles and effects.
More than 200 carefully written study questions, with answers and in-depth explanations, help readers enhance their conceptual understanding and learn and retain key information.
New and updated examples connect chapter content to real-world settings.
Interactive online simulations give students practice using different pharmacokinetic/pharmacodynamic models and parameters.
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Автор: Wagner, John G. Название: Pharmacokinetics for the Pharmaceutical Scientist ISBN: 0367402408 ISBN-13(EAN): 9780367402402 Издательство: Taylor&Francis Рейтинг: Цена: 9798.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A major presentation of pharmacokinetics by a leading international expert, this is a complete book on modeling the pharmacokinetics of drugs. It provides methods for: estimating drug disposition parameters from data obtained after intravascular or extravascular drug administration, estimating rate and extent of drug bioavailability, and comparing rate and extent of drug availability following administration of several different dosage forms of a drug. Authored by one of the founders of the field and written with insight that can only be obtained from years of experience, it is one of the very few advanced texts in the field.
Автор: Michelle A. Rudek; Cindy H. Chau; William D. Figg; Название: Handbook of Anticancer Pharmacokinetics and Pharmacodynamics ISBN: 1461491347 ISBN-13(EAN): 9781461491347 Издательство: Springer Рейтинг: Цена: 36570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book offers a detailed, step-by-step guide to the successful design and approval of anticancer drugs. It covers all steps, from the identification of cancer-specific molecular targets to clinical trial design and all the phases of clinical trials.
Автор: Michelle A. Rudek; Cindy H. Chau; William D. Figg; Название: Handbook of Anticancer Pharmacokinetics and Pharmacodynamics ISBN: 1493938983 ISBN-13(EAN): 9781493938988 Издательство: Springer Рейтинг: Цена: 34937.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. * Road map to anticancer drug development from discovery to NDA submission * Discussion of molecular targets and preclinical screening * Development and validation of bioanalytical methods * Chapters on clinical trial design and phase 0, I, II, III clinical trials * Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents * Review of the drug development process from both laboratory and clinical perspectives * New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development
Автор: A. Pecile Название: Pharmacokinetics ISBN: 146845465X ISBN-13(EAN): 9781468454659 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This unique feature of the Course is also the unique characteristic of this book which is therefore mainly directed to people interested not just in acquiring a working knowledge of the methods but in developing new methods.
Описание: Thisbook is a comprehensive resource on psychotropic medications, detailing thelatest methods for defining their characteristics, their use in differentpatient populations, and drug-drug interactions; an important collection ofinformation forclinicians, students, researchers, and members of thepharmaceutical industry alike.Thefirst section provides the foundational principles of these drugs. Mathematicalmodeling of parameters that affect their entryto,and exit from, the centralnervous system (CNS) compartment are presented on an individual basis and thenapplied to target populations with specific disease states. Methods andcharacteristics that inform the transfer of these drugs from the laboratorybench to use in patient care are discussed, including imaging techniques,genetics and physiological barriers, such as the blood-brain barrier. The secondsection describes the characteristics of specific agents,nominally arrangedintodifferent therapeutic categories and with reference crossover use indifferent disease states. The pharmacologic characteristics of different drugformulations are explored in the context of their ability to improve patientadherence. The third section focuses on drug-drug interactions.Psychotropic medicationsfrom different categories are frequently prescribed together,or alongsidemedications used to treat comorbid conditions, and the information provided isdirectly relevant to the clinic, as a result.Theclinical application of pharmacokinetics and pharmacodynamics of CNS agents hasmade significant progress over the past 50 years and new information is reportedby numerous publications in psychiatry, neurology, and pharmacology.Ourunderstanding of the interrelationship between these medications, receptors,drug transporters, as well as techniques for measurement and monitoring theirinteractions,isfrequently updated. However, with information presented on ahost of different platforms, and in different formats, obtaining the fullpicture can be difficult. This title aims to collate this information into asingle source that can be easily interpreted and applied towards patient careby the clinical practitioner, and act as a reference for all others who have aninterest in psychopharmacological agents.
Автор: Bauer Название: Applied Clinical Pharmacokinetics ISBN: 0071287264 ISBN-13(EAN): 9780071287265 Издательство: McGraw-Hill Цена: 4676.00 р. Наличие на складе: Поставка под заказ.
Автор: Tozer Название: Essential Pharmacokinetics 2E Web Pdf ISBN: 1496325915 ISBN-13(EAN): 9781496325914 Издательство: Lippincott Williams & Wilkins Рейтинг: Цена: 7864.00 р. Наличие на складе: Поставка под заказ.
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