Автор: Thomas Moehler; Hartmut Goldschmidt Название: Multiple Myeloma ISBN: 3642267998 ISBN-13(EAN): 9783642267994 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The principal focus, however, is on therapy, with detailed information on the various promising treatment options which give hope that this cancer will be transformed into a chronic disease or even become curable.
Автор: Suzanne Lentzsch Название: Genetic and Molecular Epidemiology of Multiple Myeloma ISBN: 1489998659 ISBN-13(EAN): 9781489998651 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This exploration of the role of protein translation in multiple myeloma covers recent advances in oncogenomic research that further our understanding of the disease`s molecular pathogenesis, and discusses the emerging technique of epigenetic gene silencing.
Автор: Gertz Название: Multiple Myeloma ISBN: 1461485193 ISBN-13(EAN): 9781461485193 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This is a comprehensive, state-of-the-art guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders.
Автор: Nikhil C. Munshi; Kenneth C. Anderson Название: Advances in Biology and Therapy of Multiple Myeloma ISBN: 1489989994 ISBN-13(EAN): 9781489989994 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Multiple myeloma remains incurable, immune to developments in cancer treatment such as high-dose chemotherapy and new kinds of agents. This volume assesses new approaches currently being developed that overcome drug resistance and improve patient outcomes.
Автор: Nikhil C. Munshi; Kenneth C. Anderson Название: Advances in Biology and Therapy of Multiple Myeloma ISBN: 1489989145 ISBN-13(EAN): 9781489989147 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatment paradigm targeting the tumor cell and its BM microenvironment to overcome drug resistance and improve patient outcome has now been developed. Thalidomide, lenalidomide, and Bortezomib are three agents which target the tumor cell in its microenvironment in both laboratory and animal models and which have rapidly translated from the bench to the bedside. Ongoing efforts are using oncogenomics and cell signaling studies to identify next generation of therapies in MM on the one hand, and to inform the design of combination trials on the other. This new paradigm for overcoming drug resistance and improving patient outcome in MM has great promise not only to change the natural history of MM, but also to serve as a model for targeted therapeutics directed to improve outcome of patients with MM.
Автор: G. Iris Obrams; Michael Potter Название: Epidemiology and Biology of Multiple Myeloma ISBN: 3642766579 ISBN-13(EAN): 9783642766572 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: On March 27, 1990, the National Cancer Institute sponsored a workshop on the epidemiology of multiple myeloma, held at the National Institutes of Health.
