Fluorescent Organic Nanoparticles, Waseem A. Wani; Mohammad Shahid; Afzal Hussain; Mo
Автор: Amandeep Kaur Название: Fluorescent Tools for Imaging Oxidative Stress in Biology ISBN: 3030103714 ISBN-13(EAN): 9783030103712 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This thesis advances the long-standing challenge of measuring oxidative stress and deciphering its underlying mechanisms, and also outlines the advantages and limitations of existing design strategies. It presents a range of approaches for the chemical synthesis of fluorescent probes that detect reversible changes in cellular oxidative stress. The ability to visualise cellular processes in real-time is crucial to understanding disease development and streamline treatment, and this can be achieved using fluorescent tools that can sense reversible disturbances in cellular environments during pathogenesis. The perturbations in cellular redox state are of particular current interest in medical research, since oxidative stress is implicated in the pathogenesis of a number of diseases.The book investigates different strategies used to achieve ratiometric fluorescence output of the reversible redox probes, which nullify concentration effects associated with intensity-based probes. It also describes suitable approaches to target these probes to specific cellular organelles, thereby enabling medical researchers to visualise sub-cellular oxidative stress levels, and addressing the typically poor uptake of chemical tools into biological studies. In total it reports on four new probes that are now being used by over twenty research groups around the globe, and two of which have been commercialised. The final chapters of this thesis demonstrate successful applications of the sensors in a variety of biological systems ranging from prokaryotes to mammalian cells and whole organisms. The results described clearly indicate the immense value of collaborative, cross-disciplinary research.
Описание: This thesis describes an in-depth study of an indolizine-based fluorophore, from understanding of its structure-photophysical property relationship to its application as a useful biological reporter. Organic fluorophores have been extensively used in the field of molecular biology owing to their excellent photophysical property, suitable cell permeability, and synthetic flexibility. Understanding of the structure-photophysical property relationship of a given fluorophore often paves the road to the development of valuable molecular probes to visualize and transcribe biological networks. In this thesis, respective chapters deal with molecular design, organic synthesis, structure-property analysis, and quantum-mechanical interpretation of unexplored family of indolizine-based molecules. This systematic exploration has led to rational development of a new microalgae lipid droplet probe, colorful bioorthogonal fluorogenic probes, and a bright mitochondrial probe, working under live cell conditions. Harnessing the optical properties of a given fluorophore has been an important topic for a couple of decades, both in industry and in academia. This thesis provides useful insights for the improvement and development of unique small fluorescent materials, or optical materials.
Автор: Gregor Jung Название: Fluorescent Proteins II ISBN: 3642446825 ISBN-13(EAN): 9783642446825 Издательство: Springer Рейтинг: Цена: 44582.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The discovery of the Green Fluorescent Protein, its first, seminal application and the ingenious development of a broad palette of fluorescence proteins of other colours, was consequently recognised with the Nobel Prize for Chemistry in 2008.
Автор: Kaur Название: Fluorescent Tools for Imaging Oxidative Stress in Biology ISBN: 3319734040 ISBN-13(EAN): 9783319734040 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Introduction.- Flavin based redox probes.- FRET based ratiometric redox probes.- Mitochondrially-targeted ratiometric redox probes.- Nicotinamide based ratiometric probes.- In cellulo studies.- Ex vivo studies.- Non-mammalian systems.- Conclusions.- Experimental Methods.
Автор: Xu Jiarui, Chi Zhenguo, Schneider Hans-Jorg Название: Mechanochromic Fluorescent Materials: Phenomena, Materials and Applications ISBN: 1849738211 ISBN-13(EAN): 9781849738217 Издательство: Royal Society of Chemistry Рейтинг: Цена: 32736.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Introduction to the concept of mechanofluorochromism and the variety of applications of this group of materials.
Автор: Yves Mely; Guy Duportail Название: Fluorescent Methods to Study Biological Membranes ISBN: 3642441076 ISBN-13(EAN): 9783642441073 Издательство: Springer Рейтинг: Цена: 48913.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Biological membranes play a central role in cell structure, shape and functions. However, investigating the membrane bilayer has proved to be difficult due to its highly dynamic and anisotropic structure, which generates steep gradients at the nanometer scale. Due to the decisive impact of recently developed fluorescence-based techniques, tremendous advances have been made in the last few years in our understanding of membrane characteristics and functions. In this context, the present book illustrates some of these major advances by collecting review articles written by highly respected experts. The book is organized in three parts, the first of which deals with membrane probes and model membranes. The second part describes the use of advanced quantitative and high-resolution techniques to explore the properties of biological membranes, illustrating the key progress made regarding membrane organization, dynamics and interactions. The third part is focused on the investigation of membrane proteins using the same techniques, and notably on the membrane receptors that play a central role in signaling pathways and therapeutic strategies. All chapters provide comprehensive information on membranes and their exploration for beginners in the field and advanced researchers alike.
Автор: J. Slav?k Название: Fluorescence Microscopy and Fluorescent Probes ISBN: 148991868X ISBN-13(EAN): 9781489918680 Издательство: Springer Рейтинг: Цена: 22203.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Fluorescence microscopy images can be easily integrated into current video and computer image processing systems. It also makes it possible to compute ratio images (ratio imaging both in excitation and in emission) or lifetime imaging.
Автор: Gregor Jung Название: Fluorescent Proteins I ISBN: 3642269710 ISBN-13(EAN): 9783642269714 Издательство: Springer Рейтинг: Цена: 36570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Fluorescent proteins are intimately connected to research in the life sciences. The discovery of the Green Fluorescent Protein, its first, seminal application and the ingenious development of a broad palette of fluorescence proteins of other colours, was consequently recognised with the Nobel Prize for Chemistry in 2008.
This thesis describes an in-depth study of an indolizine-based fluorophore, from understanding of its structure-photophysical property relationship to its application as a useful biological reporter.Organic fluorophores have been extensively used in the field of molecular biology owing to their excellent photophysical property, suitable cell permeability, and synthetic flexibility. Understanding of the structure-photophysical property relationship of a given fluorophore often paves the road to the development of valuable molecular probes to visualize and transcribe biological networks. In this thesis, respective chapters deal with molecular design, organic synthesis, structure-property analysis, and quantum-mechanical interpretation of unexplored family of indolizine-based molecules. This systematic exploration has led to rational development of a new microalgae lipid droplet probe, colorful bioorthogonal fluorogenic probes, and a bright mitochondrial probe, working under live cell conditions.Harnessing the optical properties of a given fluorophore has been an important topic for a couple of decades, both in industry and in academia. This thesis provides useful insights for the improvement and development of unique small fluorescent materials, or optical materials.
Автор: Markus Niederberger; Nicola Pinna Название: Metal Oxide Nanoparticles in Organic Solvents ISBN: 1447125096 ISBN-13(EAN): 9781447125099 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book discusses recent advances in the chemistry involved in the controlled synthesis and assembly of metal oxide nanoparticles. It addresses the characterization required by such nanoobjects as well as their size- and shape-dependent properties.
Автор: Markus Niederberger; Nicola Pinna Название: Metal Oxide Nanoparticles in Organic Solvents ISBN: 1848826702 ISBN-13(EAN): 9781848826700 Издательство: Springer Рейтинг: Цена: 22203.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Discusses the advances in the chemistry involved for the controlled synthesis and assembly of metal oxide nanoparticles. This book reviews and compares surfactant- and solvent-controlled routes. It provides an overview of some of the most important techniques for the characterization of metal oxide nanoparticles and crystallization pathways.
Автор: Raz Jelinek Название: Nanoparticles ISBN: 3110330024 ISBN-13(EAN): 9783110330021 Издательство: Walter de Gruyter Цена: 13008.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Nanoparticles presents the remarkable variety of nanoparticle families, compositions, structures, and functions. The book discusses nanoparticles made of semiconductors, metals, metal-oxides, organics, biological and hybrid constituents.Through a wealth of examples and case studies, supplemented by numerousfigures, readers that are not necessarily active or experts in this area acquire abroad overview of this exciting field at the interface between scientifi c research and practical technologies.The contents summarize the contributions to this field of diverse scientific and technological disciplines- chemistry, physics, biology, electronics and others providing acomprehensive knowledge- the types of nanoparticles, their compositions and how the relationships between the atomic constituents affect their properties, as well as potential applications of nanoparticles.- Covers diverse uses of nanoparticles in scientifi c research and industrial applications, underscoring their extraordinary diversity and potential utilization.- Experimental and conceptual approaches applied to the study of nanoparticles are discussed extensively. Additional references provide the reader with a basis for further study.- Also available by Professor Jelinek: Biomimetics - A Molecular Perspective (2013), ISBN: 978-3-11-028117-0
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