Progranulin, Andrew Bateman; Hugh P.J. Bennett; Siu Tim Cheung

Автор: Bateman
Название: Progranulin
ISBN: 1493985574 ISBN-13(EAN): 9781493985579
Издательство: Springer
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Цена: 15372.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Preface...Table of Contents...Contributing Authors...
Part I Introduction
1. A Brief Overview of Progranulin in Health and DiseaseAndrew Bateman, Siu Tim Cheung, and Hugh P.J. Bennett
Part II Analytical and In Vitro Methods for the Study of Progranulin Biology
2. Chromatographic Methods for the Purification of Granulin PeptidesAndrew Bateman, Babykumari Chitramuthu, and Hugh P.J. Bennett
3. Methods for Expression and Purification of Biologically Active Recombinant ProgranulinChun Yu Zhao and Andrew Bateman
4. Large-Scale Generation of Recombinant Granulin Peptides in E. coliDmitri Tolkachev
5. Nuclear Magnetic Resonance Spectroscopy in Analysis of Granulin Three-Dimensional Structure and Cysteine BridgingDmitri Tolkatchev
6. Data Mining: Applying the AD&FTD Mutation Database to ProgranulinMarc Cruts and Christine Van Broeckhoven
Part III Methods to Investigate the Role of Prgranulin in Cancer
7. Measurement of Circulating Progranulin (PGRN/GP88/GEP) by Enzyme-Linked Immunosorbent Assay and Application in Human DiseasesGinette Serrero and David Hicks
8. Immunohistochemical Detection of Progranulin (PGRN/GP88/GEP) in Tumor Tissues as a Cancer Prognostic BiomarkerGinette Serrero and David Hicks
9. Analysis of Progranulin-Mediated Akt and MAPK ActivationShi-Qiong Xu, Simone Buraschi, Ryuta Tanimoto, Manuela Stefanello, Antonio Belfiore, Renato V. Iozzo, and Andrea Morrione
10. Mouse Monoclonal Antibodies Against Progranulin (PGRN/GEP) as Therapeutics in Preclinical Cancer ModelsChi Wai Yip, Phyllis F.Y. Cheung, Nicholas C.L. Wong, Sze Wai Fung, and Siu Tim Cheung
11. Methods to Analyze the Role of Progranulin (PGRN/GEP) on Cancer Stem Cell FeaturesPhyllis F.Y. Cheung and Siu Tim Cheung
12. Methods to Study the Role of Progranulin in the Tumor MicroenvironmentMoshe Elkabets and Samuel Brook
Part IV Animal Models to Study the Role of Progragulin in Health and Disease
13. Methods to Investigate the Molecular Basis of Progranulin Action on Neurons In Vivo using Caenorhabditis elegansJames Julian Doyle and J. Alex Parker
14. The Use of Caenorhabditis elegans to Study Progranulin in the Regulation of Programmed Cell Death and Stress ResponseTsung-Yuan Hsu, Victoria J. Butler, and Aimee W. Kao
15. Application of Zebrafish and Knockdown Technology to Define Progranulin Neuronal FunctionBabykumari P. Chitramuthu and Hugh P.J. Bennett
16. Methods to Investigate the Molecular Basis of Progranulin Actions on Brain and Behavior In Vivo Using Knockout MiceJan Boddaert, Hans Wils, and Samir Kumar-Singh
17. Methods to Investigate the Protection Againts Neurodegenerative Disorders Provided by Progranulin Gene Transfer in the BrainJackalina M. Van Kampen
18. The Interaction between Progranulin with Sortilin and the LysosomeXiaolai Zhou, Peter M. Sullivan, Daniel H. Paushter, and Fenghua Hu
19. Methods to Study the Role of Progranulin in Preimplanatation Mouse Embryo DevelopmentLaura Diaz-Cueto, Fabian Arechavaleta-Velasco, and George L. Gerton
20. Establishment of a Modified Collagen-Induced Arthritis Mouse Model to Investigate the Anti-Inflammatory Activity of Progranulin in Inflammatory ArthritisJian-Iu Wei and Chuan-ju Liu

Автор: Hideaki Hara; Masato Hosokawa; Shinsuke Nakamura;
Название: Progranulin and Central Nervous System Disorders
ISBN: 9811361851 ISBN-13(EAN): 9789811361852
Издательство: Springer
Рейтинг:
Цена: 13974.00 р.
Наличие на складе: Поставка под заказ.

Описание: This book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases. Following initial recognition of the importance of PGRN in sexual differentiation of the developing brain and adult neurogenesis, it was subsequently discovered that PGRN acts as a chaperone of lysosomal enzymes and plays a crucial role in maintaining cellular protein homeostasis. It has also been found that sex steroids modulate the expression of PGRN and its trophic effects in the developing CNS and that PGRN directly or indirectly influences neural stem and progenitor cells. Against this background, deeper understanding of the molecular and functional properties of PGRN would provide fresh impetus for the development of mechanism-based therapeutic approaches for multiple disorders. Medications targeting the recovery of lysosomal function appear to hold particular promise in patients with neurodegenerative diseases resulting from PGRN insufficiency. In examining multiple aspects of this fascinating field, the book will be of high value for researchers and graduate students.

Автор: Hara Hideaki, Hosokawa Masato, Nakamura Shinsuke
Название: Progranulin and Central Nervous System Disorders
ISBN: 9811361886 ISBN-13(EAN): 9789811361883
Издательство: Springer
Рейтинг:
Цена: 13974.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases.