Progranulin and Central Nervous System Disorders, Hara Hideaki, Hosokawa Masato, Nakamura Shinsuke
Автор: Keiji Sano; Shozo Ishii Название: Plasticity of the Central Nervous System ISBN: 3709189470 ISBN-13(EAN): 9783709189474 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Distinguished experts from the fields of neurosurgery, neurology, neurophysiology, anatomy, pathology, oncology, and pharmacology discussed the following topics: - Molecular and cellular basis of plasticity - Regeneration and growth in the CNS - Self-organization of neuronal network - Brain oedema - a reparatory process?
Автор: Klaus Ballanyi Название: Isolated Central Nervous System Circuits ISBN: 1493961837 ISBN-13(EAN): 9781493961832 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Neuromethods series volume offers protocols and examples for exciting results from the labs of renowned experts. Covers patch-clamp, multiphoton imaging, live fluorescent protein expression, immunohistochemistry techniques, `organotypic` slices and more.
Автор: Hideaki Hara; Masato Hosokawa; Shinsuke Nakamura; Название: Progranulin and Central Nervous System Disorders ISBN: 9811361851 ISBN-13(EAN): 9789811361852 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Поставка под заказ.
Описание: This book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases. Following initial recognition of the importance of PGRN in sexual differentiation of the developing brain and adult neurogenesis, it was subsequently discovered that PGRN acts as a chaperone of lysosomal enzymes and plays a crucial role in maintaining cellular protein homeostasis. It has also been found that sex steroids modulate the expression of PGRN and its trophic effects in the developing CNS and that PGRN directly or indirectly influences neural stem and progenitor cells. Against this background, deeper understanding of the molecular and functional properties of PGRN would provide fresh impetus for the development of mechanism-based therapeutic approaches for multiple disorders. Medications targeting the recovery of lysosomal function appear to hold particular promise in patients with neurodegenerative diseases resulting from PGRN insufficiency. In examining multiple aspects of this fascinating field, the book will be of high value for researchers and graduate students.
Автор: Andrew Bateman; Hugh P.J. Bennett; Siu Tim Cheung Название: Progranulin ISBN: 1493993259 ISBN-13(EAN): 9781493993253 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Поставка под заказ.
Описание:
This volume explores experimental strategies to study progranulin as a regulatory protein in biological and disease processes. The chapters in this book are divided into four parts: Part One is an introduction to the topic; Part Two looks at analytical and in vitro methods to study progranulin biology; Part Three discusses the role of progranulin in cancer; and Part Four describes the process of using animal models to study progranulin in health and disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and thorough, Progranulin: Methods and Protocols is a valuable resource for experienced researchers who want to expand their studies of this field, and newcomers who want to begin including progranulin into their work.
Автор: Bateman Название: Progranulin ISBN: 1493985574 ISBN-13(EAN): 9781493985579 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Preface...Table of Contents...Contributing Authors... Part I Introduction 1. A Brief Overview of Progranulin in Health and DiseaseAndrew Bateman, Siu Tim Cheung, and Hugh P.J. Bennett Part II Analytical and In Vitro Methods for the Study of Progranulin Biology 2. Chromatographic Methods for the Purification of Granulin PeptidesAndrew Bateman, Babykumari Chitramuthu, and Hugh P.J. Bennett 3. Methods for Expression and Purification of Biologically Active Recombinant ProgranulinChun Yu Zhao and Andrew Bateman 4. Large-Scale Generation of Recombinant Granulin Peptides in E. coliDmitri Tolkachev 5. Nuclear Magnetic Resonance Spectroscopy in Analysis of Granulin Three-Dimensional Structure and Cysteine BridgingDmitri Tolkatchev 6. Data Mining: Applying the AD&FTD Mutation Database to ProgranulinMarc Cruts and Christine Van Broeckhoven Part III Methods to Investigate the Role of Prgranulin in Cancer 7. Measurement of Circulating Progranulin (PGRN/GP88/GEP) by Enzyme-Linked Immunosorbent Assay and Application in Human DiseasesGinette Serrero and David Hicks 8. Immunohistochemical Detection of Progranulin (PGRN/GP88/GEP) in Tumor Tissues as a Cancer Prognostic BiomarkerGinette Serrero and David Hicks 9. Analysis of Progranulin-Mediated Akt and MAPK ActivationShi-Qiong Xu, Simone Buraschi, Ryuta Tanimoto, Manuela Stefanello, Antonio Belfiore, Renato V. Iozzo, and Andrea Morrione 10. Mouse Monoclonal Antibodies Against Progranulin (PGRN/GEP) as Therapeutics in Preclinical Cancer ModelsChi Wai Yip, Phyllis F.Y. Cheung, Nicholas C.L. Wong, Sze Wai Fung, and Siu Tim Cheung 11. Methods to Analyze the Role of Progranulin (PGRN/GEP) on Cancer Stem Cell FeaturesPhyllis F.Y. Cheung and Siu Tim Cheung 12. Methods to Study the Role of Progranulin in the Tumor MicroenvironmentMoshe Elkabets and Samuel Brook Part IV Animal Models to Study the Role of Progragulin in Health and Disease 13. Methods to Investigate the Molecular Basis of Progranulin Action on Neurons In Vivo using Caenorhabditis elegansJames Julian Doyle and J. Alex Parker 14. The Use of Caenorhabditis elegans to Study Progranulin in the Regulation of Programmed Cell Death and Stress ResponseTsung-Yuan Hsu, Victoria J. Butler, and Aimee W. Kao 15. Application of Zebrafish and Knockdown Technology to Define Progranulin Neuronal FunctionBabykumari P. Chitramuthu and Hugh P.J. Bennett 16. Methods to Investigate the Molecular Basis of Progranulin Actions on Brain and Behavior In Vivo Using Knockout MiceJan Boddaert, Hans Wils, and Samir Kumar-Singh 17. Methods to Investigate the Protection Againts Neurodegenerative Disorders Provided by Progranulin Gene Transfer in the BrainJackalina M. Van Kampen 18. The Interaction between Progranulin with Sortilin and the LysosomeXiaolai Zhou, Peter M. Sullivan, Daniel H. Paushter, and Fenghua Hu 19. Methods to Study the Role of Progranulin in Preimplanatation Mouse Embryo DevelopmentLaura Diaz-Cueto, Fabian Arechavaleta-Velasco, and George L. Gerton 20. Establishment of a Modified Collagen-Induced Arthritis Mouse Model to Investigate the Anti-Inflammatory Activity of Progranulin in Inflammatory ArthritisJian-Iu Wei and Chuan-ju Liu
Автор: Peter Riederer; M.B.H. Youdim Название: Iron in Central Nervous System Disorders ISBN: 3211825207 ISBN-13(EAN): 9783211825204 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Thus nutritional iron defi- ciency and iron overload afflict some 500-600 million people. It is also well recognized that too little or too much iron can produce profound effects on the metabolic state of the cell, and therefore the regulation of iron uptake and disposition is tightly relegated by the cell.
Автор: Firas H. Kobeissy et al Название: Injury Models of the Central Nervous System ISBN: 1493938142 ISBN-13(EAN): 9781493938148 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume discusses experimental brain injury models thatcontain valuable information carefully chosen to widen the researchers’ horizonabout neurotrauma. Injury Models of Central Nervous System: Methods and Protocols contains relevant experimental design approaches that have beenadapted and made ready for application in laboratory settings. For easiernavigation, the chapters are categorized into 6 parts: Introduction, GeneralConsideration in Using Animal Laboratory in CNS Injury Research, Classical TBIModels and Their Link with Pathophysiological Features of CBS Injury – Models,Special Topics in CNS Trauma: Comorbid Conditions in CNS Injury, OutcomeMeasures in Brain Injury Models, and Future Directions. Written in the highly successful Methods inMolecular Biology series format, chapters include introductions to theirrespective topics, lists of the necessary materials and reagents, step-by-step,readily reproducible laboratory protocols, and tips on troubleshooting andavoiding known pitfalls.Practical and thorough, Injury Models of Central Nervous Systems: Methods and Protocols, is a very useful reference towards theprogress of this discipline.
Автор: Dwaine F. Emerich; Reginald L. Dean III; Paul R. S Название: Central Nervous System Diseases ISBN: 089603724X ISBN-13(EAN): 9780896037243 Издательство: Springer Рейтинг: Цена: 34799.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A critical review of the animal models used in developing powerful new therapies for central nervous system diseases. Techniques that rely heavily on behavioural analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology, are thoroughly explicated.
Автор: Moneeb Ehtesham Название: Stem Cell Biology in Neoplasms of the Central Nervous System ISBN: 3319165364 ISBN-13(EAN): 9783319165363 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume presents the most current reviews on how cancer stem cells (CSCs) hypothesis dictates that the continued proliferation of a tumor is dependent on a sub-population of self-renewing and asymmetrically dividing neoplastic stem cells that supply a largely differentiated tumor. This volume provides a comprehensive overview of the characteristics of CSCs, their role in central nervous system (CNS) tumors, and the recent CSC-specific treatment modalities being used. The emerging focus on CSCs in brain tumors represents a paradigm shift in our understanding of the pathogenesis of these neoplasms. Importantly, the realization that a distinct sub-population of cells contributes disproportionately to the growth and sustenance of central nervous system tumors has important implications for the treatment of such tumors. To treat CNS tumors, there is now a growing need to treat CSCs to achieve adequate tumor control.
Описание: The presence of nerve cells in the white matter of the spinal cord and in the spinal and cranial nerves has attracted the attention of some researchers in the past.
Автор: G.N. Kryzhanovsky Название: Central Nervous System Pathology ISBN: 1468478729 ISBN-13(EAN): 9781468478723 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: One hardly always receives due credit for working out a general theory. Some of them are interested in analyzing the specifics of a phenomenon, while others try to find a general regularity in an individual fact and look for its confirmation in new material.
Автор: Dorothy E. Oorschot; David G. Jones Название: Axonal Regeneration in the Mammalian Central Nervous System ISBN: 354051757X ISBN-13(EAN): 9783540517573 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
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