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Protein Allostery in Drug Discovery, Jian Zhang; Ruth Nussinov


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Автор: Jian Zhang; Ruth Nussinov
Название:  Protein Allostery in Drug Discovery
ISBN: 9789811387180
Издательство: Springer
Классификация:





ISBN-10: 9811387184
Обложка/Формат: Hardcover
Страницы: 384
Вес: 0.93 кг.
Дата издания: 2019
Серия: Advances in Experimental Medicine and Biology
Язык: English
Издание: 1st ed. 2019
Иллюстрации: 79 tables, color; 82 illustrations, color; 21 illustrations, black and white; xii, 384 p. 103 illus., 82 illus. in color.
Размер: 160 x 242 x 25
Читательская аудитория: Professional & vocational
Основная тема: Biomedicine
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: The book focuses on protein allostery in drug discovery. Allosteric regulation, ?the second secret of life?, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery—as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc.
Дополнительное описание: Chapter 1. Allostery in Drug Development.- Chapter 2. Dynamic Protein Allosteric Regulation and Disease.- Chapter 3. Protein Allostery in Rational Drug Design.- Chapter 4. Progress in Allosteric Database.- Chapter 5. Correlation between Allosteric and Ort



Allostery

Автор: Aron W. Fenton
Название: Allostery
ISBN: 149395864X ISBN-13(EAN): 9781493958641
Издательство: Springer
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Цена: 20263.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Allostery is a vital element in the formation of proteins, binding macromolecules appropriately to their function. This book provides the necessary techniques to study the phenomenon, as well as detailed practical advice to ensure optimal laboratory results.

Protein Allostery in Drug Discovery

Автор: Jian Zhang; Ruth Nussinov
Название: Protein Allostery in Drug Discovery
ISBN: 9811387214 ISBN-13(EAN): 9789811387210
Издательство: Springer
Рейтинг:
Цена: 22359.00 р.
Наличие на складе: Поставка под заказ.

Описание: The book focuses on protein allostery in drug discovery. Allosteric regulation, ?the second secret of life?, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery—as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc.

Allostery: Methods and Protocols

Автор: Di Paola Luisa, Giuliani Alessandro
Название: Allostery: Methods and Protocols
ISBN: 1071611534 ISBN-13(EAN): 9781071611531
Издательство: Springer
Цена: 15372.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This volume in the Encyclopedia of Sustainability Science and Technology, Second Edition, describes the breadth of science and engineering knowledge critical to advancing sustainable built environments, from architecture and design, mechanical engineering, lighting, and materials to water and energy, public policy, and economics.

Allosterism in Drug Discovery

Автор: Doller Dario, Rotella David
Название: Allosterism in Drug Discovery
ISBN: 1782624597 ISBN-13(EAN): 9781782624592
Издательство: Royal Society of Chemistry
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Цена: 37805.00 р.
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Описание: This book, written by the leaders in this young research area, describes the latest developments in allosterism for drug discovery.

Quantitative Aspects of Allosteric Mechanisms

Автор: A. Levitzki
Название: Quantitative Aspects of Allosteric Mechanisms
ISBN: 3642812333 ISBN-13(EAN): 9783642812330
Издательство: Springer
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Цена: 18167.00 р.
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Описание: Special emphasis has been given to the analysis of the Hill coefficient and its meaning both in thermodynamic terms and in terms of the two allosteric models: the concerted model of Monod, Wyman and Changeux and the sequential model of Koshland, Nemethy and Filmer.

Allosteric Regulatory Enzymes

Автор: Thomas W. Traut
Название: Allosteric Regulatory Enzymes
ISBN: 1441944532 ISBN-13(EAN): 9781441944535
Издательство: Springer
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Цена: 27951.00 р.
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Описание: This book covers the most recent developments in the analysis of allosteric enzymes. It provides a logical introduction to the limits for enzyme function as dictated by the factors that are limits for life.

G Protein-Coupled Receptors in Drug Discovery

Название: G Protein-Coupled Receptors in Drug Discovery
ISBN: 0367392518 ISBN-13(EAN): 9780367392512
Издательство: Taylor&Francis
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Цена: 9798.00 р.
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Описание:

The broad range of G protein-coupled receptors (GPCRs) encompasses all areas of modern medicine and have an enormous impact on the process of drug development. Using disease-oriented methods to cover everything from screening to expression and crystallization, G Protein-Coupled Receptors in Drug Discovery describes the physiological roles of GPCRs and their involvement in various human diseases.

The book presents current approaches in drug discovery that include target selection, establishment of screening and functional assays. It also covers recombinant GPCR expression for drug screening and structural biology, different methods for structural characterization of GPCRs, and the importance of bioinformatics. The book has been carefully edited to avoid overlapping information, some duplication has been intentionally permitted so that each chapter can function as an independent unit. Providing in-depth discussions on structure and dynamics of GPCRs, this book outlines the importance of the GPCRs to drug discovery in general and drug targets specifically.

Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.

Protein Interactions As Targets In Drug Discovery,121

Автор: Donev, Rossen
Название: Protein Interactions As Targets In Drug Discovery,121
ISBN: 0128168463 ISBN-13(EAN): 9780128168462
Издательство: Elsevier Science
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Цена: 21054.00 р.
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Описание:

Protein Interactions as Targets in Drug Discovery, Volume 121, is dedicated to the design of therapeutics, both experimental and computational, that target protein interactions. Chapters in this new release include Trends in structure based drug design with protein targets, From fragment- to peptide-protein interaction: addressing the structural basis of binding using Supervised Molecular Dynamics (SuMD), Protein-protein and protein-ligand interactions: identification of potential inhibitors through computational analysis, Aromatic-aromatic interactions in protein-drug and protein-protein interactions, Role of protein-protein interaction in allosteric drug design within the human methyltransferome, and much more.

Protein Kinases in Drug Discovery, 124

Автор: Donev Rossen
Название: Protein Kinases in Drug Discovery, 124
ISBN: 0323853137 ISBN-13(EAN): 9780323853132
Издательство: Elsevier Science
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Цена: 20043.00 р.
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Описание: Protein Kinases in Drug Discovery, Volume 124 discusses the latest information on protein kinases and how they modify other proteins by chemically adding phosphate groups to them. New chapters in this release include Transport Proteins and AMPs: Implications in Human Disease, Protein kinase CK2 inhibition as a pharmacological strategy, Emerging role of Protein kinase in diabetes mellitus: From Mechanism to therapy, Dual Roles of ATP-binding site in Protein Kinases: Orthosteric inhibition and Allosteric Regulation, Pseudokinases in drug discovery and development: progress, challenges and future prospects, Comparison of knowledge-based vs. combinatorial peptide library approaches for the identification of protein kinase substrates, and more.


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