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Protein Kinases in Drug Discovery, 124, Donev Rossen


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Автор: Donev Rossen
Название:  Protein Kinases in Drug Discovery, 124
ISBN: 9780323853132
Издательство: Elsevier Science
Классификация:


ISBN-10: 0323853137
Обложка/Формат: Hardcover
Страницы: 350
Вес: 4.49 кг.
Дата издания: 25.02.2021
Серия: Advances in protein chemistry and structural biology
Язык: English
Размер: 22.86 x 15.24 x 2.06 cm
Ссылка на Издательство: Link
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Поставляется из: Европейский союз
Описание: Protein Kinases in Drug Discovery, Volume 124 discusses the latest information on protein kinases and how they modify other proteins by chemically adding phosphate groups to them. New chapters in this release include Transport Proteins and AMPs: Implications in Human Disease, Protein kinase CK2 inhibition as a pharmacological strategy, Emerging role of Protein kinase in diabetes mellitus: From Mechanism to therapy, Dual Roles of ATP-binding site in Protein Kinases: Orthosteric inhibition and Allosteric Regulation, Pseudokinases in drug discovery and development: progress, challenges and future prospects, Comparison of knowledge-based vs. combinatorial peptide library approaches for the identification of protein kinase substrates, and more.


Stress-Activated Protein Kinases

Автор: Francesc Posas; Angel R. Nebreda
Название: Stress-Activated Protein Kinases
ISBN: 3540755683 ISBN-13(EAN): 9783540755685
Издательство: Springer
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Цена: 40389.00 р.
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Описание: Stress stimuli result in the rapid activation of a highly conserved group of MAP kinases, known as SAPKs (Stress-Activated Protein Kinases). These kinases coordinate the generation of adaptive responses that are essential for cell survival. This book discusses many aspects of SAPK signalling in various systems from yeast to mammals.

Inhibitors of Protein Kinases and Protein Phosphates

Автор: Lorenzo A. Pinna; Patricia T.W. Cohen
Название: Inhibitors of Protein Kinases and Protein Phosphates
ISBN: 3642422063 ISBN-13(EAN): 9783642422065
Издательство: Springer
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Цена: 69876.00 р.
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Описание: The aims of this volume are to highlight the tremendous pharmacological potential of protein kinase and protein phosphatase inhibitors, to provide a thorough overview of the most remarkable achievements in the field and to illustrate how beneficial these studies can be for the advancement of both basic knowledge on biological regulation and deregulation and for the clinical treatment of a wide spectrum of diseases. This goal is attained by contributions of leader investigators in the field, who address the issue from different angles.

Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease

Автор: Deric L. Wheeler; Yosef Yarden
Название: Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease
ISBN: 1493920529 ISBN-13(EAN): 9781493920525
Издательство: Springer
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Цена: 22203.00 р.
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Описание: Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease, for the first time, systematically covers the shared structural and functional features of the RTK family.

Receptor Tyrosine Kinases,147

Автор: Fisher, Paul B.
Название: Receptor Tyrosine Kinases,147
ISBN: 0128201428 ISBN-13(EAN): 9780128201428
Издательство: Elsevier Science
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Цена: 21054.00 р.
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Описание:

Advances in Cancer Research, Volume 147, the latest release in this ongoing, well-regarded serial, provides invaluable information on the exciting and fast-moving field of cancer research in the area of Receptor Tyrosine Kinases (RTKs) in the context of major basic science and translational advances, its importance in the development of a large number of anti-cancer drugs over the decades, and a peek into postulated advances in the coming decades for a number of RTK. Chapters in this new release has been contributed by a group of International leading scientists with a rich history of original contributions to the field.

Stress-Activated Protein Kinases

Автор: Francesc Posas; Angel R. Nebreda
Название: Stress-Activated Protein Kinases
ISBN: 3642094805 ISBN-13(EAN): 9783642094804
Издательство: Springer
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Цена: 40389.00 р.
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Описание: In this book leading researchers in the field discuss the state-of-the-art of many aspects of SAPK signaling in various systems from yeast to mammals.

Protein Kinases in Development and Disease,123

Автор: Jenny, Andreas
Название: Protein Kinases in Development and Disease,123
ISBN: 0128015136 ISBN-13(EAN): 9780128015131
Издательство: Elsevier Science
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Цена: 26107.00 р.
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Описание:

Protein Kinases in Development and Disease discusses and reviews important, but often neglected, kinases. A good representation of current model organisms from plants and C. elegans to mice are used as the basis to illustrate how we can use our understanding of normal development to learn about disease.

Abl Family Kinases in Development and Disease

Автор: Anthony Koleske
Название: Abl Family Kinases in Development and Disease
ISBN: 1489995536 ISBN-13(EAN): 9781489995537
Издательство: Springer
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Цена: 19564.00 р.
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Описание: Abl Family Kinases in Development and Disease provides an overview of the functions of Abl family kinases in Development and Disease. This new title discusses the biochemical, genetic, and cell biological data that elucidate the cellular roles for these kinases in these processes.

Cellular Bioenergetics: Role of Coupled Creatine Kinases

Автор: Valdur A. Saks; Ren?e Ventura-Clapier
Название: Cellular Bioenergetics: Role of Coupled Creatine Kinases
ISBN: 1461361192 ISBN-13(EAN): 9781461361190
Издательство: Springer
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Цена: 18284.00 р.
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Описание: The editors of this volume invited all authors who are most active at present in experimental research on creatine kinases to summarize their work and make the information easily available to a wider scientific audience, especially to young investigators who are entering this field.

Receptor-like Kinases in Plants

Автор: Frans Tax; Birgit Kemmerling
Название: Receptor-like Kinases in Plants
ISBN: 3642447988 ISBN-13(EAN): 9783642447983
Издательство: Springer
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Цена: 32004.00 р.
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Описание: Revealed by sequencing projects, receptor kinases are the largest group of primary signal transducers in plants. Their abundance hints at an immense network that we have just begun to reveal. This volume focuses on their role, signaling paths, and regulation.

Receptor Tyrosine Kinases

Автор: Serena Germano
Название: Receptor Tyrosine Kinases
ISBN: 1493954490 ISBN-13(EAN): 9781493954490
Издательство: Springer
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Цена: 13275.00 р.
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Описание:

Part I: RTKs Activation and Signalling

1. Analysis of Receptor Tyrosine Kinase (RTK) Phosphorylation by Immunoblotting

Martina McDermott and Norma O'Donovan

2. Analysis of Changes in Phosphorylation of Receptor Tyrosine Kinases: Antibody Arrays

Sweta Rani and Lorraine O'Driscoll

3. Analysis of Epidermal Growth Factor Receptor Dimerization by BS3 Crosslinking

Harmony F. Turk and Robert S. Chapkin

4. Single-Molecule Optical Methods Analyzing Receptor Tyrosine Kinase Activation in Living Cells

Inhee Chung and Ira Mellman

5. Evaluation of the Dimerization Profiles of HER Tyrosine Kinases by Time-Resolved Fцrster Resonance Energy Transfer (TR-FRET)

Evelyne Lopez-Crapez, Alexandre Ho-Pun-Cheung, Patrick Garnero, and Hervй Bazin

6. Applying the Proximity Ligation Assay (PLA) to Mouse Preimplantation Embryos for Identifying Protein-Protein Interactions In Situ

Ivan Bedzhov and Marc P. Stemmler

Part II: RTKs Aberrant Expression

7. Analysis of Receptor Tyrosine Kinase Gene Amplification on the Example of FGFR1

Diana Boehm, Anne von Mдssenhausen, and Sven Perner

8. Quantification of the Effects of Mutations on Receptor Tyrosine Kinase (RTK) Activation in Mammalian Cells

Lijuan He and Kalina Hristova

Part III: RTKs Trafficking and Negative Regulation

9. Cell Surface Biotinylation of Receptor Tyrosine Kinases to Investigate Intracellular Trafficking

Mathieu J.F. Crupi, Douglas S. Richardson, and Lois M. Mulligan

10. Studying N-Linked Glycosylation of Receptor Tyrosine Kinases

Harri M. Itkonen and Ian G. Mills

11. Identification of Receptor Protein Tyrosine Phosphatases (RPTPs) as Regulators of Receptor Tyrosine Kinases (RTKs) Using an RPTP siRNA-RTK Substrate Screen

Hojin Lee and Anton M. Bennett

12. Downregulation of Receptor Tyrosine Kinases Through Ubiquitination: Analysis by Immunodetection

Noriaki Shimokawa and Noriyuki Koibuchi

13. Regulation of Receptor Tyrosine Kinases by miRNA: Overexpression of miRNA Using Lentiviral Inducible Expression Vectors

XiangDong Le, Andrew T. Huang, Yunyun Chen, and Stephen Y. Lai

Part IV: RTKs as Pharmacological Targets

14. Human Tumor Xenografts in Mouse as a Model for Evaluating Therapeutic Efficacy of Monoclonal Antibodies or Antibody-Drug Conjugate Targeting Receptor Tyrosine Kinases

Liang Feng, Wei Wang, Hang-Ping Yao, Jianwei Zhou, Ruiwen Zhang, and Ming-Hai Wang

15. Receptor Tyrosine Kinase Targeting in Multicellular Spheroids

Susan Breslin and Lorraine O'Driscoll

16. Receptor Tyrosine Kinases and Drug Resistance: Development and Characterization of In Vitro Models of Resistance to RTK Inhibitors

Claire Corcoran and Lorraine O'Driscoll

Mitogen-Activated Protein Kinases (MAPKs): Activation, Functions and Regulation

Автор: Charles K Hester
Название: Mitogen-Activated Protein Kinases (MAPKs): Activation, Functions and Regulation
ISBN: 1536161381 ISBN-13(EAN): 9781536161380
Издательство: Nova Science
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Цена: 9819.00 р.
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Описание: Mitogen-Activated Protein Kinases (MAPKs): Activation, Functions and Regulation opens with a summary of the present knowledge about MAPK, with special emphasis on p38 and c-Jun Naterminal kinase. The authors focus on how these signaling pathways are engaged during some infections with intracellular parasites. The authors also describe selected regulatory aspects of circadian clocks in vertebrates, exploring an intriguing link to MAPK. Circadian clocks are time-tracking systems that provide organisms with a survival advantage. Cadmium, one of the toxic metals, is an important occupational and environmental pollutant that damages various organs, especially the kidney. The concluding study proposes that the type of kidney cell and severity of cadmium-induced cellular stress appear to determine the effect of MAPK on cell fate.


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