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Allostery: Methods and Protocols, Di Paola Luisa, Giuliani Alessandro


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Автор: Di Paola Luisa, Giuliani Alessandro
Название:  Allostery: Methods and Protocols
ISBN: 9781071611531
Издательство: Springer
Классификация:
ISBN-10: 1071611534
Обложка/Формат: Hardcover
Страницы: 274
Вес: 0.68 кг.
Дата издания: 15.01.2021
Язык: English
Размер: 26.16 x 19.81 x 1.78 cm
Ссылка на Издательство: Link
Поставляется из: Германии
Описание: This volume in the Encyclopedia of Sustainability Science and Technology, Second Edition, describes the breadth of science and engineering knowledge critical to advancing sustainable built environments, from architecture and design, mechanical engineering, lighting, and materials to water and energy, public policy, and economics.


Protein Allostery in Drug Discovery

Автор: Jian Zhang; Ruth Nussinov
Название: Protein Allostery in Drug Discovery
ISBN: 9811387184 ISBN-13(EAN): 9789811387180
Издательство: Springer
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Цена: 22359.00 р.
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Описание: The book focuses on protein allostery in drug discovery. Allosteric regulation, ?the second secret of life?, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery—as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc.

Protein Allostery in Drug Discovery

Автор: Jian Zhang; Ruth Nussinov
Название: Protein Allostery in Drug Discovery
ISBN: 9811387214 ISBN-13(EAN): 9789811387210
Издательство: Springer
Рейтинг:
Цена: 22359.00 р.
Наличие на складе: Поставка под заказ.

Описание: The book focuses on protein allostery in drug discovery. Allosteric regulation, ?the second secret of life?, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery—as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc.

Allostery

Автор: Aron W. Fenton
Название: Allostery
ISBN: 149395864X ISBN-13(EAN): 9781493958641
Издательство: Springer
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Цена: 20263.00 р.
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Описание: Allostery is a vital element in the formation of proteins, binding macromolecules appropriately to their function. This book provides the necessary techniques to study the phenomenon, as well as detailed practical advice to ensure optimal laboratory results.

Allosterism in Drug Discovery

Автор: Doller Dario, Rotella David
Название: Allosterism in Drug Discovery
ISBN: 1782624597 ISBN-13(EAN): 9781782624592
Издательство: Royal Society of Chemistry
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Цена: 37805.00 р.
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Описание: This book, written by the leaders in this young research area, describes the latest developments in allosterism for drug discovery.

Nanopore Technology: Methods and Protocols

Автор: Fahie Monifa A. V.
Название: Nanopore Technology: Methods and Protocols
ISBN: 1071608053 ISBN-13(EAN): 9781071608050
Издательство: Springer
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Цена: 15372.00 р.
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Описание: This detailed collection explores techniques involved in the main strategies of nanopore sensing, such as translocation, analyte trapping, and interactions with external binding sites. Opening with a section on nanopore design and nanopore production, the book continues with parts devoted to various biological nanopores, nanopore engineering, and their uses in single molecule sensing, computational methods to study intrinsic nanopore behavior, characterizing the specific translocation activity of a vesicle particle through a nanopore, as well as the use of the technique droplet interface bilayer (DIB) in nanopore and membrane biophysical studies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Nanopore Technology: Methods and Protocols, with its focus on nanopore technology and biomolecule characterization, will hold the interest of the biophysicists, biochemists, bioengineers, and molecular biologists who are working toward further understanding this key field of research.

Argonaute Proteins: Methods and Protocols

Автор: Hobman Tom C., Duchaine Thomas F.
Название: Argonaute Proteins: Methods and Protocols
ISBN: 1493958275 ISBN-13(EAN): 9781493958276
Издательство: Springer
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Цена: 20263.00 р.
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Описание: With the rapid proliferation of RNAi applications in basic and clinical sciences, the challenge has now become understanding how components of RNAi machinery function together in a regulated manner. Argonaute proteins are the central effectors of RNAi and are highly conserved among eukaryotes and some archaebacteria. These RNA-binding proteins use small guide RNAs to silence expression of genes at the mRNA and DNA levels. In Argonaute Proteins: Methods and Protocols, expert researchers in this burgeoning field provide detailed, up-to-date methods to study Argonaute protein functions and interactions in a wide variety of cell types ranging from yeast to mammalian systems, as well as in vitro. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Practical and authoritative, Argonaute Proteins: Methods and Protocols serves as a vital reference for both experienced and novice scientists approaching the vast complexities of RNAi research.

Mucins: Methods and Protocols

Автор: McGuckin Michael A., Thornton David J.
Название: Mucins: Methods and Protocols
ISBN: 1493958860 ISBN-13(EAN): 9781493958863
Издательство: Springer
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Цена: 15372.00 р.
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Описание: Epithelial mucins are large complex cell surface and secreted glycoproteins produced by mucosal epithelial cells. In, Mucins: Methods and Protocols expert researchers in the field detail many of the methods which are now commonly used to study Mucins. These include methods and techniques for the best approaches to analysing each specific area of mucin biochemistry, physiology and biophysics before providing individual detailed experimental protocols together with troubleshooting and interpretation tips. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Mucins: Methods and Protocols is designed to be a useful resource for those entering the mucin field and to facilitate those already studying mucins to broaden their experimental approaches to understanding mucosal biology.

Intrinsically Disordered Proteins: Methods and Protocols

Автор: Kragelund Birthe B., Skriver Karen
Название: Intrinsically Disordered Proteins: Methods and Protocols
ISBN: 1071605232 ISBN-13(EAN): 9781071605233
Издательство: Springer
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Цена: 39130.00 р.
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Описание: The edition details methods to study intrinsically disordered proteins (IDPs) including recent topics such as extremely high-affinity disordered complexes, kinetics that evade established concepts, liquid-liquid phase separation, and novel disorder-driven allosteric mechanisms. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Intrinsically Disordered Proteins: Methods and Protocols aims to help scientists with different backgrounds to further their investigations into these fascinating and dynamic molecules. Chapter 24 is available open access under a CC BY 4.0 license via link.springer.com. Chapters “40 and 42 ” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Membrane Protein Structure and Function Characterization: Methods and Protocols

Автор: Lacapere Jean-Jacques
Название: Membrane Protein Structure and Function Characterization: Methods and Protocols
ISBN: 1493983997 ISBN-13(EAN): 9781493983995
Издательство: Springer
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Цена: 19564.00 р.
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Описание: In this present volume, different approaches are detailed to produce membrane proteins, purify them, study their function, determine their structure, and model them in membrane.

Opioid Receptors: Methods and Protocols

Автор: Spampinato Santi M.
Название: Opioid Receptors: Methods and Protocols
ISBN: 1071608835 ISBN-13(EAN): 9781071608838
Издательство: Springer
Цена: 18167.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Chapters detail transcriptional and post-transcriptional analysis, cellular detection of opioid receptors, analysis of signaling events modulated by opioid receptors, model systems to studying opioid receptor-mediated functions, and behavioral effects mediated by opioid receptors.

Expressed Protein Ligation: Methods and Protocols

Автор: Vila-Perellу Miquel
Название: Expressed Protein Ligation: Methods and Protocols
ISBN: 1071604333 ISBN-13(EAN): 9781071604335
Издательство: Springer
Рейтинг:
Цена: 15372.00 р.
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Описание: This book provides a comprehensive overview of Expressed Protein Ligation (EPL), detailing methods and protocols to generate site-specifically modified proteins. Chapters include an overview of the protein semi-synthesis field, as well as related areas that have contributed to the development of EPL such as protein splicing and peptide synthesis. Following the introductory chapters, the rest of the book guides readers through protocols to perform EPL reactions, methods to synthesize peptide thioesters and to perform peptide and protein ligations, label proteins inside living cells, protocols for the semi-synthesis of phorphorylated, glycosylated and ubiquitylated proteins, synthesis and assembly of assymetrically modified nucleosomes, use of ligation auxiliaries and synthesis of cyclic proteins, as well as novel desulfurization strategies and use of selective Cys side chain protection to obtain precisely modified proteins.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Expressed Protein Ligation: Methods and Protocols will ensure successful implementation of protein semi-synthesis methods to further study the structure and function of proteins.

Protein Function Prediction: Methods and Protocols

Автор: Kihara Daisuke
Название: Protein Function Prediction: Methods and Protocols
ISBN: 1493983687 ISBN-13(EAN): 9781493983681
Издательство: Springer
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Цена: 19564.00 р.
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Описание: Preface...
Table of Contents...
Contributing Authors...

1. Using PFP and ESG Protein Function Prediction Web Servers
Qing Wei, Joshua McGraw, Ishita Khan, and Daisuke Kihara

2. GHOSTX: A Fast Sequence Homology Search Tool for Functional Annotation of Metagenomic Data
Shuji Suzuki, Takashi Ishida, Masahito Ohue, Masanori Kakuta, and Yutaka Akiyama

3. From Gene Annotation to Function Prediction for Metagenomics
Fatemeh Sharifi and Yuzhen Ye

4. An Agile Functional Analysis of Metagenomic Data using SUPER-FOCUS
Genivaldo Gueiros Z. Silva, Fabyano A. C. Lopes, and Robert A. Edwards

5. MPFit: Computational Tool for Predicting Moonlighting Proteins
Ishita Khan, Joshua McGraw, and Daisuke Kihara

6. Predicting Secretory Proteins with SignalP
Henrik Nielsen

7. The ProFunc Function Prediction Server
Roman A. Laskowski

8. G-LoSA for Prediction of Protein-Ligand Binding Sites and Structures
Hui Sun Lee and Wonpil Im

9. Local Alignment of Ligand Binding Sites in Proteins for Polypharmacology and Drug Repositioning
Michal Brylinski

10. WATsite2.0 with PyMOL Plugin: Hydration Site Prediction and Visualization
Ying Yang, Bingjie Hu, and Markus A. Lill

11. Enzyme Annotation and Metabolic Reconstruction Using KEGG
Minoru Kanehisa

12. Ortholog Identification and Comparative Analysis of Microbial Genomes using MBGD and RECOG
Ikuo Uchiyama

13. Exploring Protein Function Using the Saccharomyces Genome Database
Edith D. Wong

14. Network-Based Gene Function Prediction in Mouse and Other Model Vertebrates using MouseNet Server
Eiru Kim and Insuk Lee

15. The FANTOM5 Computation Ecosystem: Genomic Information Hub for Promoters and Active Enhancers
Imad Abugessaisa, Shuhei Noguchi, Piero Carninci, and Takeya Kasukawa

16. Multi-Algorithm Particle Simulations with Spatiocyte
Satya N. V. Arjunan and Koichi Takahashi


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