Retinal Degeneration, Bernhard H. F. Weber; Thomas Langmann
Автор: Bernhard H.F. Weber; THOMAS LANGMANN Название: Retinal Degeneration ISBN: 1493959697 ISBN-13(EAN): 9781493959693 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Methods in Molecular Biology (TM) book offers methods for studying retinal homeostasis and disease, including cell culture systems and animal models of disease, their generation, phenotypic and molecular characterization and use in therapeutic approaches.
Автор: Penn Название: Retinal and Choroidal Angiogenesis ISBN: 9048177243 ISBN-13(EAN): 9789048177240 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides a comprehensive, in-depth review of our current understanding of the growth of blood vessels within the eye. The book emphasizes basic principles rather than specific experimental results, although recently acquired data is frequently cited to illustrate points of broader theoretical significance.
Автор: Pang, Iok-Hou; Clark, Abbot F. (Eds.) Pang, Iok-H Название: Animal models for retinal diseases series: neuromethods, vol. 46 ISBN: 1607615401 ISBN-13(EAN): 9781607615408 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Retinal diseases are among the leading causes of irreversible visual impairment and blindness. This vital book provides an easily accessible and authoritative reference for animal models of the most common and important retinal diseases.
Автор: Shu-Zhen Wang Название: Retinal Development ISBN: 1493962523 ISBN-13(EAN): 9781493962525 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book details the protocols used for a wide range of experiments in retinal research, including manipulating gene expression in vivo, retinal regeneration and stem cell-based replacement, and non-invasive imaging techniques such as electroretinography.
Автор: Weber Название: Retinal Degeneration ISBN: 1493986686 ISBN-13(EAN): 9781493986682 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Part I: Molecular Genetics and Tools
1 Identification and Analysis of Genes Associated with Inherited Retinal Diseases
Mubeen Khan, Zeinab Fadaie, Stйphanie S. Cornelis, Frans P.M. Cremers, and Susanne Roosing
2 eQTL Analysis in Retinal Research
Felix Gra mann
3 Testing for known Retinal Degeneration Mutants in Mouse Strains
Khalid Rashid, Katharina Dannhausen, and Thomas Langmann
4 CRISPR/Cas9 Gene Editing In Vitro and in Retinal Cells In Vivo
Daniela Benati, Valeria Marigo, and Alessandra Recchia
5 Monitoring Surface Reactions by Combined Western Blot-ELISA Analysis
Yuchen Lin, Sarah Irmscher, and Christine Skerka
Part II: Cell/Tissue Culture Models
6 Generation of Functional Retinal Pigment Epithelium from Human Induced Pluripotent Stem Cells Caroline Brandl
7 Advanced Analysis of Photoreceptor Outer Segment Phagocytosis by RPE Cells in Culture Francesca Mazzoni, Yingyu Mao, and Silvia C. Finnemann
8 Porcine RPE/Choroidal Explant Cultures
Alexa Klettner and Yoko Miura
9 The Mouse Retinal Organoid Trisection Recipe: Efficient Generation of 3D Retinal Tissue from Mouse Embryonic Stem Cells
Manuela Vцlkner, Thomas Kurth, and Mike O. Karl
10 Cell Death Analysis in Retinal Cultures
Sarah L Roche, Ana M Ruiz-Lopez, and Thomas G Cotter
11 Fate Mapping In Vivo to Distinguish Bona Fide Microglia Versus Recruited Monocyte-derived Macrophages in Retinal Disease
Nancy J Reyes, Rose Mathew, and Daniel R Saban
Part III: Animal Models
12 Light Damage Models of Retinal Degeneration
Christian Grimm and Charlotte E. Reme
13 Induction and Readout of Oxygen-Iinduced Retinopathy
Raffael Liegl, Claudia Priglinger, and Andreas Ohlmann
14 Generation and Analysis of Xenopus laevis Models of Retinal Degeneration using CRISPR/Cas9
Joanna M. Feehan, Paloma Stanar, Beatrice M. Tam, Colette Chiu, and Orson L. Moritz
15 Gene Knockdown in Zebrafish (Danio rerio) as a Tool to Model Photoreceptor Diseases
Holger Dill and Utz Fischer
16 Drosophila melanogaster - A Valuable Genetic Model Organism to Elucidate the Biology of Retinitis Pigmentosa
Malte Lehmann, Elisabeth Knust, and Sarita Hebbar
Part IV: Retinal Imaging
17 Retinal Fundus Imaging in Mouse Models of Retinal Diseases
Anne F. Alex, Maged Alnawaiseh, Peter Heiduschka, and Nicole Eter
18 Phenotyping of Mouse Models with OCT
G. Alex Ochakovski and M. Dominik Fischer
19 Cell-specific Markers for the Identification of Retinal Cells and Subcellular Organelles by Immunofluorescence Microscopy
Laurie L. Molday, Christiana L. Cheng, and Robert S. Molday
20 Immuno-TEM/STEM in Retinal Research
Sanae Sakami and Krzysztof Palczewski
21 Noninvasive Two-photon Microscopy Imaging of Mouse Retina and Retinal Pigment Epithelium
Grazyna Palczewska, Timothy S. Kern, and Krzysztof Palczewski
Part V: Th
Автор: Naoyuki Tanimoto Название: Mouse Retinal Phenotyping ISBN: 1493992678 ISBN-13(EAN): 9781493992676 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Поставка под заказ.
Описание: The aim of this volume is to provide a wide range of techniques and aspects of mouse retinal phenotyping and characterization. Chapters guide readers through morphological and functional properties of the mouse retina and techniques for the analysis of outer to mid-retina and mid- to inner retina. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mouse Retinal Phenotyping: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Автор: Reinhard Rohkamm Название: Degeneration and Regeneration in Neurons of the Cerebellum ISBN: 354008519X ISBN-13(EAN): 9783540085195 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The normal anatomy of the cerebellum has been thoroughly studied by numerous in- vestigators over many years. Anatomical aspects in terms of evolution (Dow, 1942; Larsell, 1967; Llinas, 1969; Gregory, 1975), correlative anatomy (Wallenberg, 1931), and morphology (Larsell, 1952; L0ning and Jansen, 1955; Ludwig-Hauri, 1955; Braitenberg and Atwood, 1958; Jansen und Brodal, 1958; Zeman and Innes, 1963) have been presented. Histological features have attracted many investigators (Bergmann, 1857; Denis- senko, 1877; Ramon y Cajal and Illera, 1907; Addison, 1911; Jakob, 1928; Snider and Jacobs, 1949; Braitenberg and Atwood, 1958; Baud, 1959; Altman, 1962, 1963, 1966, 1971, 1972a, b, c, 1973a, b, 1975; Birch-Anderson et aI., 1962; Andres, 1965; Eccles et aI., 1967; Fox and Snider, 1967; Mugnaini and Forstrl1. lDen, 1967; Del Cerro and Snider, 1968, 1972a, b; O'Leary et aI., 1968, 1971; Chan-Palay and Palay, 1970, 1971, 1972; Rakic and Sidman, 1970; Das and Altman, 1971; Gobel, 1971; Rakic, 1971; 1972a, b; Chan-Palay, 1972a, b, 1973c, d; Palay and Chan-Palay, 1972, 1974; Sidman and Rakic, 1973; Spacek et aI., 1973; Das et al., 1974; Braak, 1975; Crepel and Mariani, 1975; Derrnietzel, 1975a, b; Gregory, 1975; Llinas, 1975; Meller and Tetzlaff, 1975; Cragg, 1976; Rees et aI., 1976; Zelevic and Rakic, 1976). Investigators of the cytologi- cal characteristics of the cerebellar cortex are numerous (Sternberg and Krombholtz, 1838; Smirnow, 1897; Ramon y Fananas, 1916; Larramendi et al.
Автор: Marco A. Zarbin; Mandeep S. Singh; Ricardo P. Casa Название: Cell-Based Therapy for Degenerative Retinal Disease ISBN: 3030052214 ISBN-13(EAN): 9783030052218 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book discusses why specific diseases are being targeted for cell-based retinal therapy, what evidence exists that justifies optimism for this approach, and what challenges must be managed in order to bring this technology from the laboratory into routine clinical practice. There are a number of unanswered questions (e.g., surgical approach to cell delivery, management of immune response, optimum cell type to transplant) that very likely are not going to be answered until human trials are undertaken, but there is a certain amount of “de-risking” that can be done with preclinical experimentation. This book is essential reading for scientists, clinicians, and advanced students in stem cell research, cell biology, and ophthalmology.
Автор: Tanimoto Название: Mouse Retinal Phenotyping ISBN: 1493977199 ISBN-13(EAN): 9781493977192 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Part I: Overview
1 Morphological Survey from Neurons to Circuits of the Mouse Retina
Yoshihiko Tsukamoto
2 Measuring Retinal Function in the Mouse
Jan Kremers and Naoyuki Tanimoto
3 Modeling Retinal Diseases Using Genetic Approaches in Mice
Akiko Maeda and Tadao Maeda
Part II: Outer to Mid-Retina
4 Cell Culture Analysis of the Phagocytosis of Photoreceptor Outer Segments by Primary Mouse RPE Cells
Roni A. Hazim and David S. Williams
5 Two-photon Microscopy (TPM) and Fluorescence Lifetime Imaging Microscopy (FLIM) of Retinal Pigment Epithelium (RPE) of Mice In Vivo
Yoko Miura
6 RPE Visual Cycle and Biochemical Phenotypes of Mutant Mouse Models
Bhubanananda Sahu and Akiko Maeda
7 Use of Direct Current Electroretinography for Analysis of Retinal Pigment Epithelium Function in Mouse Models
Minzhong Yu and Neal S. Peachey
8 Disruption of Rhodopsin Dimerization in Mouse Rod Photoreceptors by Synthetic Peptides Targeting Dimer Interface
Sandeep Kumar, Alyssia Lambert, Jon Rainier, and Yingbin Fu
9 Experimental Approaches for Defining the Role of the Ca2+-Modulated ROS-GC System in Retinal Rods of the Mouse
Clint L. Makino, Teresa Duda, Alexandre Pertzev, and Rameshwar K. Sharma
10 Microglia Analysis in Retinal Degeneration Mouse Models
Katharina Dannhausen, Khalid Rashid, and Thomas Langmann
11 Determination Of Mitochondrial Oxygen Consumption in the Retina Ex-vivo: Applications for Retinal Disease
Yogita K. Adlakha and Anand Swaroop
12 Analysis of Feedback Signaling from Horizontal Cells to Photoreceptors in Mice
Arlene A. Hirano, Xue Liu, Nicholas C. Brecha, and Steven Barnes
13 Assessment of the Absolute Excitatory Level of the Retina by Flicker Erg
Naoyuki Tanimoto and Mathias W. Seeliger
14 Ex Vivo Functional Evaluation of Synaptic Transmission from Rods to Rod Bipolar Cells in Mice
Johan Pahlberg, Anurima Majumder, and Nikolai O. Artemyev
15 Functional And Morphological Analysis of Off Bipolar Cells
Chase B. Hellmer and Tomomi Ichinose
Part III: Mid- To Inner Retina
16 Immunohistochemical Phenotyping Of Mouse Amacrine Cell Subtypes
Denize Atan
17 Phenotyping of Gap-junctional Coupling in the Mouse Retina
Arndt Meyer, Shubhash C. Yadav, and Karin Dedek
18 Ganglion Cell Assessment in Rodents with Retinal Degeneration
Erica L. Fletcher, Ursula Greferath, Susmita Saha, Emily E. Anderson, and Kirstan A. Vessey
19 Morphological Identification of Melanopsin Expressing Retinal Ganglion Cell Subtypes in Mice
Seul Ki Lee and Tiffany M. Schmidt
20 Functional Assessment of Melanopsin-driven Light Responses in the Mouse: Multielectrode Array Recordings
Shi-Jun Weng, Jordan M. Renna, Wei-Yi Chen, and Xiong-Li Yang
21 In Vitro Assays for Mouse Mьller Cell Phenotyping through Microrna Profiling in the Damaged Retina
Luis I. Reyes-Aguirre, Heberto Quintero, Brenda Estrada-Leyva, and Monica Lamas
22 Analysis Of Retinal Vascular Plexi and Interplexus Connections
Aaron B. Simmons and Peter G. Fuerst
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