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Mouse Retinal Phenotyping, Naoyuki Tanimoto


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Автор: Naoyuki Tanimoto
Название:  Mouse Retinal Phenotyping
ISBN: 9781493992676
Издательство: Springer
Классификация:



ISBN-10: 1493992678
Обложка/Формат: Soft cover
Страницы: 334
Вес: 0.66 кг.
Дата издания: 2018
Серия: Methods in Molecular Biology
Язык: English
Издание: Softcover reprint of
Иллюстрации: 51 tables, color; 52 illustrations, color; 23 illustrations, black and white; xi, 334 p. 75 illus., 52 illus. in color.
Размер: Book (Paperback Initiative)
Читательская аудитория: Professional & vocational
Основная тема: Biomedicine
Подзаголовок: Methods and Protocols
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: The aim of this volume is to provide a wide range of techniques and aspects of mouse retinal phenotyping and characterization. Chapters guide readers through morphological and functional properties of the mouse retina and techniques for the analysis of outer to mid-retina and mid- to inner retina. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.   Authoritative and cutting-edge, Mouse Retinal Phenotyping: Methods and Protocols aims to ensure successful results in the further study of this vital field. 
Дополнительное описание: Morphological Survey from Neurons to Circuits of the Mouse Retina.- Measuring Retinal Function in the Mouse.- Modeling Retinal Diseases Using Genetic Approaches in Mice.- Cell Culture Analysis of the Phagocytosis of Photoreceptor Outer Segments by Primary



Morphological Mouse Phenotyping

Автор: Ruberte, Jose
Название: Morphological Mouse Phenotyping
ISBN: 0128129727 ISBN-13(EAN): 9780128129722
Издательство: Elsevier Science
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Цена: 22254.00 р.
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Описание:

Morphological Mouse Phenotyping: Anatomy, Histology and Imaging is an atlas of explanatory diagrams and text that guides the reader through normal mouse anatomy, histology, and imaging. The book is targeted for mouse researchers and veterinarian and human pathologists, and presents a complete, integrative description of normal mouse morphology.

Disease animal models are fundamental in research to improve human health. The success of using genetically engineered mice to evaluate molecular disease hypotheses has encouraged the development of massive global projects, making the mouse the most used animal disease model. Laboratory mouse populations are straining the housing capacity of pharmaceutical and biotechnology companies, as well as public research institutions. However, the scientific community lacks sufficient expertise in morphological phenotyping to effectively characterize and validate these animal models. The mouse displays fundamental morphological similarities to humans; however, a mouse is not a man.

  • Features more than 2,200 original images showing the anatomy, histology, and cellular structure of mouse organs
  • Includes images specifically produced for this book in the Mouse Imaging Platform (Center for Animal Biotechnology and Gene Therapy, Universitat Aut noma de Barcelona)
  • Offers an integrative vision of mouse morphology using correlative X-ray, computed tomography, magnetic resonance, and ultrasound images
  • Employs classical anatomical techniques such as conventional dissection, skeletal preparations, vascular injections, and histological, immunohistochemical, and electron microscopy techniques to characterize mouse morphology
Digital Phenotyping and Mobile Sensing

Автор: Harald Baumeister and Christian Montag
Название: Digital Phenotyping and Mobile Sensing
ISBN: 303031619X ISBN-13(EAN): 9783030316198
Издательство: Springer
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Цена: 22359.00 р.
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Описание: This book offers a snapshot of cutting-edge applications of mobile sensing for digital phenotyping in the field of Psychoinformatics. Insel, who wrote the foreword to this book: "Patients will only use digital phenotyping if it solves a problem, perhaps a digital smoke alarm that can prevent a crisis.

Mouse Retinal Phenotyping

Автор: Tanimoto
Название: Mouse Retinal Phenotyping
ISBN: 1493977199 ISBN-13(EAN): 9781493977192
Издательство: Springer
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Цена: 23757.00 р.
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Описание:

Part I: Overview

1 Morphological Survey from Neurons to Circuits of the Mouse Retina

Yoshihiko Tsukamoto

2 Measuring Retinal Function in the Mouse

Jan Kremers and Naoyuki Tanimoto

3 Modeling Retinal Diseases Using Genetic Approaches in Mice

Akiko Maeda and Tadao Maeda

Part II: Outer to Mid-Retina

4 Cell Culture Analysis of the Phagocytosis of Photoreceptor Outer Segments by Primary Mouse RPE Cells

Roni A. Hazim and David S. Williams

5 Two-photon Microscopy (TPM) and Fluorescence Lifetime Imaging Microscopy (FLIM) of Retinal Pigment Epithelium (RPE) of Mice In Vivo

Yoko Miura

6 RPE Visual Cycle and Biochemical Phenotypes of Mutant Mouse Models

Bhubanananda Sahu and Akiko Maeda

7 Use of Direct Current Electroretinography for Analysis of Retinal Pigment Epithelium Function in Mouse Models

Minzhong Yu and Neal S. Peachey

8 Disruption of Rhodopsin Dimerization in Mouse Rod Photoreceptors by Synthetic Peptides Targeting Dimer Interface

Sandeep Kumar, Alyssia Lambert, Jon Rainier, and Yingbin Fu

9 Experimental Approaches for Defining the Role of the Ca2+-Modulated ROS-GC System in Retinal Rods of the Mouse

Clint L. Makino, Teresa Duda, Alexandre Pertzev, and Rameshwar K. Sharma

10 Microglia Analysis in Retinal Degeneration Mouse Models

Katharina Dannhausen, Khalid Rashid, and Thomas Langmann

11 Determination Of Mitochondrial Oxygen Consumption in the Retina Ex-vivo: Applications for Retinal Disease

Yogita K. Adlakha and Anand Swaroop

12 Analysis of Feedback Signaling from Horizontal Cells to Photoreceptors in Mice

Arlene A. Hirano, Xue Liu, Nicholas C. Brecha, and Steven Barnes

13 Assessment of the Absolute Excitatory Level of the Retina by Flicker Erg

Naoyuki Tanimoto and Mathias W. Seeliger

14 Ex Vivo Functional Evaluation of Synaptic Transmission from Rods to Rod Bipolar Cells in Mice

Johan Pahlberg, Anurima Majumder, and Nikolai O. Artemyev

15 Functional And Morphological Analysis of Off Bipolar Cells

Chase B. Hellmer and Tomomi Ichinose

Part III: Mid- To Inner Retina

16 Immunohistochemical Phenotyping Of Mouse Amacrine Cell Subtypes

Denize Atan

17 Phenotyping of Gap-junctional Coupling in the Mouse Retina

Arndt Meyer, Shubhash C. Yadav, and Karin Dedek

18 Ganglion Cell Assessment in Rodents with Retinal Degeneration

Erica L. Fletcher, Ursula Greferath, Susmita Saha, Emily E. Anderson, and Kirstan A. Vessey

19 Morphological Identification of Melanopsin Expressing Retinal Ganglion Cell Subtypes in Mice

Seul Ki Lee and Tiffany M. Schmidt

20 Functional Assessment of Melanopsin-driven Light Responses in the Mouse: Multielectrode Array Recordings

Shi-Jun Weng, Jordan M. Renna, Wei-Yi Chen, and Xiong-Li Yang

21 In Vitro Assays for Mouse Mьller Cell Phenotyping through Microrna Profiling in the Damaged Retina

Luis I. Reyes-Aguirre, Heberto Quintero, Brenda Estrada-Leyva, and Monica Lamas

22 Analysis Of Retinal Vascular Plexi and Interplexus Connections

Aaron B. Simmons and Peter G. Fuerst

Machine Learning for Microbial Phenotype Prediction

Автор: Feldbauer
Название: Machine Learning for Microbial Phenotype Prediction
ISBN: 3658143185 ISBN-13(EAN): 9783658143183
Издательство: Springer
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Цена: 11101.00 р.
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Описание: This thesis presents a scalable, generic methodology for microbial phenotype prediction based on supervised machine learning, several models for biological and ecological traits of high relevance, and the deployment in metagenomic datasets. The results suggest that the presented prediction tool can be used to automatically annotate phenotypes in near-complete microbial genome sequences, as generated in large numbers in current metagenomic studies. Unraveling relationships between a living organism's genetic information and its observable traits is a central biological problem. Phenotype prediction facilitated by machine learning techniques will be a major step forward to creating biological knowledge from big data.

Retinal Degeneration

Автор: Bernhard H.F. Weber; THOMAS LANGMANN
Название: Retinal Degeneration
ISBN: 1493959697 ISBN-13(EAN): 9781493959693
Издательство: Springer
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Цена: 20263.00 р.
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Описание: This Methods in Molecular Biology (TM) book offers methods for studying retinal homeostasis and disease, including cell culture systems and animal models of disease, their generation, phenotypic and molecular characterization and use in therapeutic approaches.

Cell-Based Therapy for Degenerative Retinal Disease

Автор: Marco A. Zarbin; Mandeep S. Singh; Ricardo P. Casa
Название: Cell-Based Therapy for Degenerative Retinal Disease
ISBN: 3030052214 ISBN-13(EAN): 9783030052218
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This book discusses why specific diseases are being targeted for cell-based retinal therapy, what evidence exists that justifies optimism for this approach, and what challenges must be managed in order to bring this technology from the laboratory into routine clinical practice. There are a number of unanswered questions (e.g., surgical approach to cell delivery, management of immune response, optimum cell type to transplant) that very likely are not going to be answered until human trials are undertaken, but there is a certain amount of “de-risking” that can be done with preclinical experimentation. This book is essential reading for scientists, clinicians, and advanced students in stem cell research, cell biology, and ophthalmology.

Retinal and Choroidal Angiogenesis

Автор: Penn
Название: Retinal and Choroidal Angiogenesis
ISBN: 9048177243 ISBN-13(EAN): 9789048177240
Издательство: Springer
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Цена: 20263.00 р.
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Описание: This book provides a comprehensive, in-depth review of our current understanding of the growth of blood vessels within the eye. The book emphasizes basic principles rather than specific experimental results, although recently acquired data is frequently cited to illustrate points of broader theoretical significance.

Retinal Development

Автор: Shu-Zhen Wang
Название: Retinal Development
ISBN: 1493962523 ISBN-13(EAN): 9781493962525
Издательство: Springer
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Цена: 18167.00 р.
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Описание: This book details the protocols used for a wide range of experiments in retinal research, including manipulating gene expression in vivo, retinal regeneration and stem cell-based replacement, and non-invasive imaging techniques such as electroretinography.

Retinal Degeneration

Автор: Bernhard H. F. Weber; Thomas Langmann
Название: Retinal Degeneration
ISBN: 1493993607 ISBN-13(EAN): 9781493993604
Издательство: Springer
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Цена: 23757.00 р.
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Описание: This volume provides key updates on several methods from the first edition as well as including new novel techniques to address the most recent technological developments and their applications in retinal research Chapters guide readers through gene identification approaches, detailed protocols to generate functional retinal pigment epithelium cells, mouse retina and other animal models, fundus imaging and angiography, and cell-based treatment approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Retinal Degeneration: Methods and Protocols, Second Edition aims to ensure successful scientific work in the further study of this vital field.

Animal models for retinal diseases series: neuromethods, vol. 46

Автор: Pang, Iok-Hou; Clark, Abbot F. (Eds.) Pang, Iok-H
Название: Animal models for retinal diseases series: neuromethods, vol. 46
ISBN: 1607615401 ISBN-13(EAN): 9781607615408
Издательство: Springer
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Цена: 22359.00 р.
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Описание: Retinal diseases are among the leading causes of irreversible visual impairment and blindness. This vital book provides an easily accessible and authoritative reference for animal models of the most common and important retinal diseases.

A Probabilistic Model of the Genotype/Phenotype Relationship

Автор: Jean-Pierre Hugot
Название: A Probabilistic Model of the Genotype/Phenotype Relationship
ISBN: 1138320722 ISBN-13(EAN): 9781138320727
Издательство: Taylor&Francis
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Цена: 29093.00 р.
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Описание: This book provides a new hypothesis on the relationship between genotype and phenotype. The main idea is that this relationship is probabilistic, in other words, the genotype does not fully explain the phenotype. This book discusses the current knowledge on complex genetic diseases, phenotypic plasticity, canalization and others.

Retinal Degeneration

Автор: Weber
Название: Retinal Degeneration
ISBN: 1493986686 ISBN-13(EAN): 9781493986682
Издательство: Springer
Рейтинг:
Цена: 23757.00 р.
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Описание:

Part I: Molecular Genetics and Tools

1 Identification and Analysis of Genes Associated with Inherited Retinal Diseases

Mubeen Khan, Zeinab Fadaie, Stйphanie S. Cornelis, Frans P.M. Cremers, and Susanne Roosing

2 eQTL Analysis in Retinal Research

Felix Gra mann

3 Testing for known Retinal Degeneration Mutants in Mouse Strains

Khalid Rashid, Katharina Dannhausen, and Thomas Langmann

4 CRISPR/Cas9 Gene Editing In Vitro and in Retinal Cells In Vivo

Daniela Benati, Valeria Marigo, and Alessandra Recchia

5 Monitoring Surface Reactions by Combined Western Blot-ELISA Analysis

Yuchen Lin, Sarah Irmscher, and Christine Skerka

Part II: Cell/Tissue Culture Models

6 Generation of Functional Retinal Pigment Epithelium from Human Induced Pluripotent Stem Cells

Caroline Brandl

7 Advanced Analysis of Photoreceptor Outer Segment Phagocytosis by RPE Cells in Culture

Francesca Mazzoni, Yingyu Mao, and Silvia C. Finnemann

8 Porcine RPE/Choroidal Explant Cultures

Alexa Klettner and Yoko Miura

9 The Mouse Retinal Organoid Trisection Recipe: Efficient Generation of 3D Retinal Tissue from Mouse Embryonic Stem Cells

Manuela Vцlkner, Thomas Kurth, and Mike O. Karl

10 Cell Death Analysis in Retinal Cultures

Sarah L Roche, Ana M Ruiz-Lopez, and Thomas G Cotter

11 Fate Mapping In Vivo to Distinguish Bona Fide Microglia Versus Recruited Monocyte-derived Macrophages in Retinal Disease

Nancy J Reyes, Rose Mathew, and Daniel R Saban

Part III: Animal Models

12 Light Damage Models of Retinal Degeneration

Christian Grimm and Charlotte E. Reme

13 Induction and Readout of Oxygen-Iinduced Retinopathy

Raffael Liegl, Claudia Priglinger, and Andreas Ohlmann

14 Generation and Analysis of Xenopus laevis Models of Retinal Degeneration using CRISPR/Cas9

Joanna M. Feehan, Paloma Stanar, Beatrice M. Tam, Colette Chiu, and Orson L. Moritz

15 Gene Knockdown in Zebrafish (Danio rerio) as a Tool to Model Photoreceptor Diseases

Holger Dill and Utz Fischer

16 Drosophila melanogaster - A Valuable Genetic Model Organism to Elucidate the Biology of Retinitis Pigmentosa

Malte Lehmann, Elisabeth Knust, and Sarita Hebbar

Part IV: Retinal Imaging

17 Retinal Fundus Imaging in Mouse Models of Retinal Diseases

Anne F. Alex, Maged Alnawaiseh, Peter Heiduschka, and Nicole Eter

18 Phenotyping of Mouse Models with OCT

G. Alex Ochakovski and M. Dominik Fischer

19 Cell-specific Markers for the Identification of Retinal Cells and Subcellular Organelles by Immunofluorescence Microscopy

Laurie L. Molday, Christiana L. Cheng, and Robert S. Molday

20 Immuno-TEM/STEM in Retinal Research

Sanae Sakami and Krzysztof Palczewski

21 Noninvasive Two-photon Microscopy Imaging of Mouse Retina and Retinal Pigment Epithelium

Grazyna Palczewska, Timothy S. Kern, and Krzysztof Palczewski

Part V: Th


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